@LoebLab
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Seeking molecular mediators of kidney disease through human genetics, genomics, and novel experimental models. @UCSF, @UCSFNephrology
Joined August 2022
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Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.
Thank you to @kidneyomicsamps and @MagdalenaRiedlK for the thoughtful editorial on our paper functionalizing 𝘗𝘒𝘋1 variants and implications for polycystic kidney disease (ADPKD) genetic testing and treatment. DOI: 10.1681/ASN.0000001174 journals.lww.com/jasn/fullte…
We are constantly thinking about how to integrate human genetics and better experimental models to identify the mechanisms of human disease @UCSFNephrology, @IHG_at_UCSF, @UCSFDOM . Funding for the next generation of medicine from @NIH.
Critiques and feedback welcome!
Gabriel Loeb retweeted
What an awesome session on common variant CKD genetics @ASNKidney #KidneyWk @kidneyomicsamps @LoebLab @LimdiNita
Gabriel Loeb retweeted
Incredible session on Genetics in Kidney Disease #KidneyWeek @ASNKidney
Outstanding organization & insightful talks by @Vishal_D_Patel #DanielGale #AliGharavi #GabrielLoeb
Grateful for the opportunity to present on Genetics of TMA🙏
Thx #ArleneChapman & #EmilieCornecLeGall
🧬Very nice talk about genetics of TMA by @anuja_java at #KidneyWk
👉🏽 Interplay between genetics and triggers
👉🏽Who should we test?
Thank you @ASNKidney! Our lab is very grateful to receive the 2025 Carl W. Gottschalk Research Scholar Grant. Read more about the work here: kidneycure.org/pages/qa.aspx….
Gabriel Loeb retweeted
#Whyscience Day51🧠✨A strong finish to our Renal Grand rounds series by a rising star physician scientists @LoebLab @UCSFNephrology Pushing the frontiers of kidney genomics and single cell omics. The future of nephrology is bright🔆
Steven Pinker:
And if you’re still skeptical that universities are worth supporting, consider these questions: Do you think that the number of children who die every year from cancer is just about right?
Exciting paper by @CanaudLab in @jclinicalinvest--doi.org/10.1172/JCI176402. 1) Somatic mutation as a (presumably) very rare cause of FSGS, 2) Targeting the mutated gene PIK3CA is helpful in multiple mouse FSGS models, 3) Activity of podocyte targeted therapy in mouse FSGS.
Gabriel Loeb retweeted
We are pleased to announce that the first participant has been dosed in our Phase 1 clinical trial evaluating MZE782. MZE782 is a potentially first-in-class, oral, small molecule targeting the solute transporter, SLC6A19, and has the potential to address chronic #kidneydisease (CKD) patients. Learn more about the MZE782 program here: businesswire.com/news/home/2…
