@IsnardPierre1

MD, PhD, Kidney Pathology, Institut Necker Enfants Malades, Paris, France

Joined November 2022
  • Tweets388
  • Following147
  • Followers133
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Jul 30
🔥🎆Our newest paper is out !!! @NatureGenet How does the kidney build its filtering units, each from the same small pool of stem cells? Jon Levisohn, Alex Hughes lab mapped human kidney development cell by cell, in space, and found it is far more flexible than the textbook teaches. nature.com/articles/s41588-0…
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Jul 24
1/ 🚨 Out today in @ScienceAdvances , and I could not be more excited. ELF3: a GWAS gene that reprograms injured kidney tubules. science.org/doi/epdf/10.1126… GWAS have handed nephrology more than 1000 kidney function loci. Here we nail one down: ELF3 is the effector gene at an eGFR GWAS locus. When we delete it in a sick kidney, injured proximal tubule cells turn back toward a normal epithelial state. 🧵
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Jul 24
👏 📄 awesome paper by Junnan Wu (Susztaklab alumni) -Single cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury | @ScienceAdvances science.org/doi/10.1126/scia…

Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of...

PDE4DIP emerges as a potential target for protecting podocytes and preserving kidney filtration.

science.org
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Isnard Pierre retweeted
Haikuo Li@HaikuoLi
Jul 15
JCI Insight - Shared mechanisms of organ fibrosis insight.jci.org/articles/vie… @HumphreysLab
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Next-generation kidney tissue analysis — spatial omics and digital pathology dlvr.it/TTWmzG

Next-generation kidney tissue analysis — spatial omics and digital pathology

Nature Reviews Nephrology - In this Review, the authors discuss the advantages, limitations and applications of spatial omics technologies in kidney research. They also discuss novel imaging...

nature.com
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Jul 10
Universal cell embedding provides a foundation model for cell biology | @nature @jure nature.com/articles/s41586-0…

Universal cell embedding provides a foundation model for cell biology

Nature - The universal cell embedding foundation model learns to capture the organization and variation of cells by training on 36 million cells from hundreds of experiments, dozens of tissues and...

nature.com
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HNF1B as a central gatekeeper of tubular homeostasis dlvr.it/TSrQMr

HNF1B as a central gatekeeper of tubular homeostasis

Nature Reviews Nephrology - HNF1B as a central gatekeeper of tubular homeostasis

nature.com
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Our latest paper just released. Congratulations to Ilaria, Charles and the entire team 🍾🥳🔥Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosaic overgrowth disorders academic.oup.com/pnasnexus/a…

Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosaic overgrowth disorders

Abstract. PIK3CA-related overgrowth spectrum (PROS) comprises a group of rare genetic disorders caused by de novo, mosaic, postzygotic gain-of-function mut

academic.oup.com
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Isnard Pierre retweeted
Haikuo Li@HaikuoLi
May 9
Check out our recent work on @NatureComms! Greatly appreciate my mentors and collaborators making this possible. We developed epi-Patho-DBiT, a unified platform that enables spatially resolved ATAC -seq or CUT&Tag analyses in FFPE tissues!
Rong Fan@RongFan8
May 8
Excited to see this in print! Kudos to Haikuo, Bo, and the entire team including @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute to explore this clinically relevant area of lymphoma transformation with truly innovative technology. @theNCI #HTAN nature.com/articles/s41467-0…

Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via...

Nature Communications - Li, Tao, and colleagues present epi-Patho-DBiT to spatially map chromatin accessibility and histone modifications in archived human lymphoma tissues, revealing epigenetic...

nature.com
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Apr 29
We generated a spatial atlas from 64 human kidney samples to define kidney niches and characterize fibrosis through injured tubular microenvironments. We built a spatial immune atlas to study renal inflammation, uncovering a B cell-predominant immune microenvironment in DKD that correlated with disease severity and kidney function decline.
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Apr 17
Congrats to @IsnardPierre1 and Marco Pontoglio HNF1B integrates signals in a feed-forward loop driving kidney disease progression | Happy to have contributed with Jon Levinsohn @ScienceMagazine science.org/doi/10.1126/scie…

HNF1B integrates signals in a feed-forward loop driving kidney disease progression

Chronic kidney disease (CKD), which affects more than 10% of the global population, may continue to progress even after the triggering insult has resolved, suggesting the involvement of self-sustai...

science.org
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Thrilled to share our work! Immensely grateful to my incredible mentors, Fabiola and Marco, to all co-authors, and to Science for publishing and supporting our work ! science.org/doi/10.1126/scie…

HNF1B integrates signals in a feed-forward loop driving kidney disease progression

Chronic kidney disease (CKD), which affects more than 10% of the global population, may continue to progress even after the triggering insult has resolved, suggesting the involvement of self-sustai...

science.org
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Isnard Pierre retweeted
Katalin Susztak
@KSusztak
Apr 15
🚨 Our new paper just dropped !!! Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes nature.com/articles/s41591-0…
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Isnard Pierre retweeted
nature
@Nature
Apr 9
Nature research paper: Multiomics and deep learning dissect regulatory syntax in human development go.nature.com/4cinsmn

Multiomics and deep learning dissect regulatory syntax in human development

Nature - The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for...

nature.com
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Isnard Pierre retweeted
dana_peer@dana_peer
Mar 27
I am very pleased with our latest paper, spearheaded by 3 incredibly talented first authors @chris_cowley14,@LFSoto12 and @SairajSajjath with @ElaineFuchsLab. Here we show that cells can remember past injury for a long time! science.org/doi/10.1126/scie…

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory

Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understo...

science.org
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Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized. pubmed.ncbi.nlm.nih.gov/4172… #renalpath #pathtwitter #nephrology
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Isnard Pierre retweeted
Waggoner Lab@LabWaggoner
Mar 28
Whole-body molecular and cellular mapping of the laboratory mouse @CellCellPress @UChicagoPME cell.com/cell/fulltext/S0092… 🇨🇳🇺🇸
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What extraordinary news — I’m extremely proud and honored. Thank you @eshgsociety for this very prestigious award, which I share with the entire team. 🎉🍾🥂
European Society of Human Genetics (ESHG)@eshgsociety
Mar 10
The ESHG Award, ELPAG Award and the Mendel Lecturers of the #eshg2026 #hybridconference have talked to Mary Rice. Read the interviews and find out more about their backgrounds: 2026.eshg.org/speakers/speak…
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Isnard Pierre retweeted
Pradeep Natarajan
@pnatarajanmd
Mar 11
Always special to write papers with @kidneyomicsamps, good friend, colleague, and neighbor (@broadinstitute & @TownofBrookline) jamanetwork.com/journals/jam… @JAMANetworkOpen
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Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR go.nature.com/4rZqimf
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