Synthetic biologist engineering mitochondria, RNA and new gene editing systems. NHMRC Investigator and Professor @CurtinUni @CurtinMRI and @TheKids_AU
Perth, Western Australia
Joined November 2017
- Tweets117
- Following855
- Followers1K
- Likes1.9K
Oliver Rackham retweeted
We’re hiring! 🧬
Exciting opportunities in mitochondrial genome engineering and therapies for mitochondrial disease with @FilipovskaLab in sunny Western Australia ☀️
and at our biotech CodeBreakers
Apply: au.seek.com/job/94426759
#Mitochondria #GenomeEngineering #Postdoc #Biotech
Oliver Rackham retweeted
Sun, surf and scientific talks 😎
Centre Director Ian Paulsen and COO J-L Heylen joined CoESB researchers from our @uwanews and @CurtinUni nodes for their annual Theme 2 (Synthetic Organelles) Retreat on Rottnest Island in sunny WA 🌊☀️ @TheRackhamLab @FilipovskaLab @arc_gov_au
Oliver Rackham retweeted
It takes two to TANGO2!
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers.
rdcu.be/epI3p
#metabolism
Oliver Rackham retweeted
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
Oliver Rackham retweeted
Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact.
biorxiv.org/content/10.1101/…
Muscle mito nanotunnels 1/3🧵
Oliver Rackham retweeted
Online Now: Interorganelle phospholipid communication, a house not so divided dlvr.it/T9GyHt #trends #endocrinology #metabolism
Oliver Rackham retweeted
Unique architectural features of mammalian mitochondrial protein synthesis dlvr.it/T854Mm
Oliver Rackham retweeted
Unique architectural features of mammalian mitochondrial protein synthesis
30-day free access to our new review at: authors.elsevier.com/a/1jE3u…
Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.
Oliver Rackham retweeted
Mutational rescue of the activity of high-fidelity Cas9 enzymes dlvr.it/T5NxQL
Oliver Rackham retweeted
Are you tired of slow gene editing and scattershot targeting?
Well no more, here we introduce HyperDriveCas9.
An engineered Cas9 variant that is both hyperactive and hyper accurate.
doi.org/10.1016/j.crmeth.202…
Oliver Rackham retweeted
💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics.
rdcu.be/duKqS
nature.com/articles/s41556-0…
Oliver Rackham retweeted
Quantitative volumetric analyses and morphological interactions supported by multi-omic profiling identify global organelle defects and mitochondrial dysfunction that can be rescued with ether lipids. nature.com/articles/s41556-0…
#FIBSEM #3D #mitochondria #organelles #lipids
Oliver Rackham retweeted
A new report has found that medical research in WA:
🇦🇺Returns $2.61 to Aus for every $1 invested
💼Added 2,632 jobs to WA in 2021
💰Contributed $322.9m to WA economy in 2021
👏Thank you: @telethonkids @ear_science @PerkinsComms @PerronInstitute @LionsEyeInstAus @Resp_Health
Oliver Rackham retweeted
The mitochondrial genome is expressed in platelets and essential for blood clotting and response to injury. cell.com/cell-reports/fullte…
#mitoribosome #translation #RNA #platelets
Oliver Rackham retweeted
Our study showing that ATFS-1 acts as a molecular switch to prioritise mtDNA repair over expression, thereby reducing age-dependent mtDNA damage, is out today in @NatureCellBio !
Congrats Michael on your paper! @Michaeldcy1
@QldBrainInst
nature.com/articles/s41556-0…
Oliver Rackham retweeted
How to stop in a noncanonical way: @The_Ban_Lab (@ETH_en ), with the @FilipovskaLab & Gatfield lab, uncovered the unusual molecular mechanism by which mtRF1 recognizes noncanonical #stop codons in human #mitochondria to terminate #translation!
bit.ly/3p49y26
#ribosome
Oliver Rackham retweeted
Wonderful collaboration with @FilipovskaLab reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. @ScienceMagazine
science.org/doi/10.1126/scie…
Oliver Rackham retweeted
Mitochondria have converted codons for amino acids into signals that terminate protein synthesis.
Ribosome profiling and cryo-EM uncover a unique conformation between an extension in mtRF1 and the codon, mRNA and rRNA that enables this feat.
science.org/doi/full/10.1126…
Oliver Rackham retweeted
Online today! 👉Multi-omic profiling reveals an #RNAprocessing rheostat that predisposes to #prostatecancer
By M. Stentenbach, A. Filipovska & colleagues @FilipovskaLab @PerkinsComms
🗞️Read #openaccess: doi.org/10.15252/emmm.202317…
Oliver Rackham retweeted
Defects in noncoding RNA processing activate tumorigenic pathways and identify an ELAC2 variant as a predisposing factor for prostate cancer.
Multi-omic profiling reveals changes that underly prostate tumorigenesis. #RNA #ncRNA
embopress.org/doi/10.15252/e…
