Synthetic biologist engineering mitochondria, RNA and new gene editing systems. NHMRC Investigator and Professor @CurtinUni @CurtinMRI and @TheKids_AU
Perth, Western Australia
Joined November 2017
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The discovery of CRYAB as the binding partner of TANGO2 highlights the importance of intermediate filaments in metabolism and mitochondrial function and reveals the molecular basis of TANGO2 deficiency disorder (TDD)
nature.com/articles/s41467-0…
#metabolism
#mitochondria
@NatureComms
Oliver Rackham retweeted
We’re hiring! 🧬
Exciting opportunities in mitochondrial genome engineering and therapies for mitochondrial disease with @FilipovskaLab in sunny Western Australia ☀️
and at our biotech CodeBreakers
Apply: au.seek.com/job/94426759
#Mitochondria #GenomeEngineering #Postdoc #Biotech
Oliver Rackham retweeted
Sun, surf and scientific talks 😎
Centre Director Ian Paulsen and COO J-L Heylen joined CoESB researchers from our @uwanews and @CurtinUni nodes for their annual Theme 2 (Synthetic Organelles) Retreat on Rottnest Island in sunny WA 🌊☀️ @TheRackhamLab @FilipovskaLab @arc_gov_au
Oliver Rackham retweeted
It takes two to TANGO2!
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers.
rdcu.be/epI3p
#metabolism
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia?
Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable
staff.curtin.edu.au/explore-…
Oliver Rackham retweeted
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
Destroyer turned protector - FASTKD4 uses it’s Vsr nuclease-like structure to protect the polyadenylated tail of the mitochondrial MT-ND3 mRNA
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
Oliver Rackham retweeted
Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact.
biorxiv.org/content/10.1101/…
Muscle mito nanotunnels 1/3🧵
Better CRISPR base editors!
More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases.
@ACSSynBio
pubs.acs.org/doi/10.1021/acs…
Organelles within mammalian cells are surprisingly interconnected, and lipids play a critical role
Check out: Interorganelle phospholipid communication, a house not so divided @Trends_Endo_Met to see more
cell.com/trends/endocrinolog…
#metabolism
#mitochondria
#lipids
#Golgi
#ER
Oliver Rackham retweeted
Online Now: Interorganelle phospholipid communication, a house not so divided dlvr.it/T9GyHt #trends #endocrinology #metabolism
Illuminating mitochondrial translation through mouse models
@hmg_journal
academic.oup.com/hmg/article…
#mitochondria
#mtDNA
Oliver Rackham retweeted
Unique architectural features of mammalian mitochondrial protein synthesis dlvr.it/T854Mm
Oliver Rackham retweeted
Unique architectural features of mammalian mitochondrial protein synthesis
30-day free access to our new review at: authors.elsevier.com/a/1jE3u…
Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.
High-fidelity Cas9 variants that prevent off-target cleavage typically reduce on-target activity. Adding TurboCas9 mutations to these enzymes can improve activity while maintaining off-target fidelity. @CellRepMethods
cell.com/cell-reports-method…
Oliver Rackham retweeted
Mutational rescue of the activity of high-fidelity Cas9 enzymes dlvr.it/T5NxQL
Oliver Rackham retweeted
Are you tired of slow gene editing and scattershot targeting?
Well no more, here we introduce HyperDriveCas9.
An engineered Cas9 variant that is both hyperactive and hyper accurate.
doi.org/10.1016/j.crmeth.202…
Oliver Rackham retweeted
💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiomics to show that ether-#lipid #metabolism regulates inter-organelle biogenesis and dynamics.
rdcu.be/duKqS
nature.com/articles/s41556-0…
Oliver Rackham retweeted
Quantitative volumetric analyses and morphological interactions supported by multi-omic profiling identify global organelle defects and mitochondrial dysfunction that can be rescued with ether lipids. nature.com/articles/s41556-0…
#FIBSEM #3D #mitochondria #organelles #lipids
Check out this elegant News and Views @NatureCellBio by Antentor Hinton Jr @phdgprotein86 and Andrea Marshall @DrDreNeuroWay, highlighting the importance of organelle interconnectivity:
nature.com/articles/s41556-0…