Sytse Piersma retweeted
Using an inducible genetic mouse model, researchers found that during ATP citrate lyase is required for upregulating glycolysis IL-15 priming, NK cell proliferation, cytotoxicity, and activating certain receptors. Read more: ow.ly/z3Tm50XS9Ro.
ALT Acly deficiency alters the expression of DAP10 and DAP12 protein. (A) NK1.1 activates Syk/ZAP70 through FcRγ. Ly49H and NKG2D are associated with adaptor proteins DAP10 and DAP12. DAP12 transduces signal to Syk/Zap70, whereas DAP10 activates PI3K and Vav1. Created in BioRender: Cooper, M. (2025) (https://BioRender.com/b54u773)
Sytse Piersma retweeted
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
ALT Loss of uNK cells in the pregnant uterus reduced litter sizes and increased resorptions rates.
Sytse Piersma retweeted
I am pleased to share with you that my paper has been accepted in Nature rdcu.be/dOPyr
This work would not have been possible without the guidance of an exceptional mentor, support of awesome lab members and collaborators. @washupathedu @NateraGenetics @parkerici
Sytse Piersma retweeted
Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today cell.com/cell-stem-cell/full…
extensive 15-post-🧵 below
Sytse Piersma retweeted
NK cell IFNγ induces resistance of tumors to NK cells by upregulating classical & non-classical MHC-I, where therapeutic combination of monalizumab/lirilumab/DX9 may fully restore the antitumor response across NK cell subsets @capslocked_me @CerwenkaLab
jitc.bmj.com/content/12/7/e0…
Sytse Piersma retweeted
I have waited for this moment my entire PhD for @LabWaggoner to tweet about my work!!
IL-12/15/18 differentially activate NK cell subsets driving unique memory-like programs with implications for NK cell therapy @SciImmunology Congrats @FoltzPhd @LabFehniger @Jenn__Tran
science.org/doi/10.1126/scii…
Sytse Piersma retweeted
Expression of Ly49A alone on a H-2Dd background restored missing-self target cell rejection, NK cell licensing, and NK cell KLRG1 expression, therefore a single inhibitory Ly49 receptor is sufficient to license NK cells @SytseP #Yokoyama
doi.org/10.1101/2024.06.04.5…
Sytse Piersma retweeted
Cis-regulatory evolution of the recently expanded Ly49 gene family @NatureComms @twang5 @SytseP #Yokoyama @ChangxuFan
nature.com/articles/s41467-0…
Sytse Piersma retweeted
NK cells were first described five decades ago and named in 1975. This brief Perspective from Lewis Lanier @UCSF highlights a timeline of a few selected advancements in NK cell biology in each decade. hubs.la/Q02zRMB70
🎥 See video summary: hubs.la/Q02zRKh80
Sytse Piersma retweeted
In the mouse, I believe the most NK cell-specific gene is Ly49h. I found its enhancer! Read about my discovery of MAP8 here: nature.com/articles/s41467-0…
Many thanks to @twang5, @SytseP , and Wayne Yokoyama for the tremendous support!
Sytse Piersma retweeted
CD8α status identifies human NK cell capacity for IL-15-induced proliferation and metabolism in a time-dependent fashion and exhibits a suppressive effect on NK cell activating receptors @jclinicalinvest @LabFehniger @CeliaCubitt
jci.org/articles/view/173602
Sytse Piersma retweeted
Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard]
nature.com/articles/s41467-0…
Sytse Piersma retweeted
Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered universal capacity forCD300a to protect allogeneic T cells from NK cells
biorxiv.org/content/10.1101/…
Sytse Piersma retweeted
In this article, we provide a brief perspective of the promise of allogeneic cell therapies against cancer. We consider rejection by the recipient as a central pitfall and discuss approaches to reduce this rejection by genetic engineering
nature.com/articles/s41577-0…
Sytse Piersma retweeted
Tissue-specific features of ILCs in antiviral defense
REVIEW by @SytseP
nature.com/articles/s41423-0…
Online now in Cellular and Molecular Immunology: my review on the role of ILCs in virus infection with a focus on tissue specific features. nature.com/articles/s41423-0…
Sytse Piersma retweeted
.@SytseP, @sushantbangru, @KalsotraLab, Yokoyama @WUSTLmed and colleagues reveal that HuR-dependent NK cell expansion is required for control of long-term virus infection and solid tumors without affecting acute infection or tumor metastases. bit.ly/44Tzflg
Sytse Piersma retweeted
In @JExpMed, Sytse Piersma @SytseP, Sushant Bangru @sushantbangru, Yokoyama et al. identify a crucial role for post-transcriptional regulation by HuR in NK cell proliferation, which is required for control of long-term virus infection and solid tumors. bit.ly/44Tzflg
Thrilled to see our story out on HuR-dependent NK cell proliferation in virus infection and tumor control out in @JExpMed. Big thanks to everybody making this study possible, including our collaborators @sushantbangru and @KalsotraLab at @UIUC_Biochem. bit.ly/44Tzflg
