@KalsotraLab

Kalsotra Lab at Department of Biochemistry, University of Illinois, Urbana-Champaign. We investigate RNA processing and its role in health and disease.

 Urbana, IL
kalsotralab.web.illinois.edu/
Joined September 2018
  • Tweets1.3K
  • Following400
  • Followers539
33Media
Kalsotra Lab retweeted
Jason Shepherd@JasonSynapticApr 10
It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants. Reviewers, program officials and funders can be more empathetic in the face of all the chaos in the US scientific enterprise.
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New Online! Signal control during tissue regeneration in adult animals bit.ly/3XnzvHP
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Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease | Nature Communications nature.com/articles/s41467-0…

Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease

Nature Communications - Liver regeneration often fails during chronic liver disease. Here, the authors conduct multiomic profiling of human livers to demonstrate that RNA splicing is dysregulated...

nature.com
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Drs. Anna Mae Diehl & Auinash Kalsotra led this study reporting that in alcohol-associated liver disease, alterations in the hepatic immune milieu prevent #hepatocytes from transitioning to proliferative progenitors. 👉 go.nature.com/3VfAyst
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📰DNS Faculty in the News! Dr. Auinash Kalsotra’s team shows how disrupted RNA splicing halts liver regeneration in alcohol-associated liver disease 🔗Read more: tinyurl.com/AuinashK #NutritionalSciences #DNSatUofI #interdisciplinary #research #DNSfaculty #LiverHealth
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What movie is 10/10, yet hardly anyone has heard of it?
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Beautiful work, congrats Eddie!
NatureStructMolBiol@NatureSMB19 Jun 2025
New online! ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism bit.ly/4kNfh4m
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“To write for impact means to keep it as simple as possible.” Good read and very insightful. nature.com/articles/s41587-0…
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In this study, Bangru et al. describe a regulatory switch that controls hepatocyte polyploidization and maturation through the activation of an RNA alternative splicing program that promotes cytokinesis failure and binucleation. Learn more here: ➡️ tinyurl.com/gd352129
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A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide — also known as Ozempic — in suppressing appetite and reducing body weight. stan.md/3Xv96bw
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Kalsotra Lab retweeted
Kalsotra Lab@KalsotraLab1 Feb 2025
🚨 New research from @KalsotraLab uncovers how ESRP2 drives hepatocyte maturation & polyploidization via the microRNA-122 axis—key for liver #regeneration & #disease resistance. Findings could boost efforts in #regenerative #medicine. @NIAAAnews @czbiohub genesdev.org/cgi/doi/10.1101…
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Kalsotra Lab retweeted
Itai Yanai
@ItaiYanai15 Feb 2025
We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come!
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This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:
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🚨 New research from @KalsotraLab uncovers how ESRP2 drives hepatocyte maturation & polyploidization via the microRNA-122 axis—key for liver #regeneration & #disease resistance. Findings could boost efforts in #regenerative #medicine. @NIAAAnews @czbiohub genesdev.org/cgi/doi/10.1101…
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Thank you @sarakosman @NatureSMB for featuring our two studies on #MALAT1 & #NEAT1 on the Nov cover! Led by @IliasSkeparnias we describe how #lncRNA partially mimic #tRNA structure for their maturation and #mascRNA #menRNA biogenesis. nature.com/nsmb/volumes/31/i…
https://www.nature.com/articles/s41594-024-01340-4 https://www.nature.com/articles/s41594-024-01361-z

ALT https://www.nature.com/articles/s41594-024-01340-4 https://www.nature.com/articles/s41594-024-01361-z

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Kalsotra Lab retweeted
elvis
@omarsar011 Nov 2024
We live in incredible times.
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Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters dlvr.it/TG6q0F
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Kalsotra Lab retweeted
Razvan Borza@rborza_5 Nov 2024
AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔 ➡️ AlphaBridge will identify the most confident interactions, making your analysis easier! 🌐Try it here: alpha-bridge.eu 👀Read more: biorxiv.org/content/10.1101/…
The left panel displays the pLDDT of the prediction, while the right panel shows the reliable interfaces Images created with Blender and Molecular Nodes

ALT The left panel displays the pLDDT of the prediction, while the right panel shows the reliable interfaces Images created with Blender and Molecular Nodes

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We are excited to announce that the RNA 2025 Annual Meeting website is live! #RNA25 www2.rnasociety.org Limited rooms are available at a special RNA 2025 rate to stay at the beautiful Town and Country Resort & Convention Center, so please book today! www2.rnasociety.org/conferen…
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www2.rnasociety.org Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January @RNASociety Note the fabulous artwork by former @EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
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