@StrickerLab

Musculoskeletal Development and Regeneration Lab, Division of Cell Biology, Karl Landsteiner University of Health Sciences. Stromal cells rule!

kl.ac.at/en/university/faculties/department-cell-biology
Joined September 2017
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Happy to share the latest paper from our lab: rdcu.be/eYaRP where we propose that multipotent progenitors from the dorsal aortic compartment in E9.5 mouse embryos contribute to the formation of brown adipose tissue depots
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Hey Muscle And Metabolism Folks on Twitter, @LykkeSylow and I are looking for a Postdoc who is interested in applying for a prestigious @DDEA_Denmark fellowship with us. More details in the picture attached. Please share widely! @MYOTWlTTER
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Only a few more days left to register for the German Society for Developmental Biology (GfE) Summer school vbio.de/gfe-entwicklungsbiol…
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StrickerLab retweeted
Rüegg Lab@RueggLab4 Apr 2025
Myc and muscle growth: necessary in muscle stem cells, dispensable in muscle fibers and harmful if overexpressed. Check out our latest work rdcu.be/eggcw in @NatureComms, where we explore the role of Myc in muscle growth and more.
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Development@Dev_journal5 Sep 2024
Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation Read this Research Article by Pedro Vallecillo-García, Sigmar Stricker @StrickerLab (@FU_Berlin @ChariteBerlin) and colleagues: journals.biologists.com/dev/…
Figure 2A-B: Lack of Osr1 in mesenchymal cells leads to lymphatic vasculature defects. (A) Maximal intensity projection images of Osr1+/+ and Osr1GCE/GCE E11.5 100 µm cross-sections after immunofluorescence. Immunolabeling for PROX1, VEGFR3 and PECAM1 shows normal commitment and delamination of LECs and normal blood endothelial structures in the dorsal part of the cardinal vein. Below, quantification of PROX1+ nuclei inside of the cardinal vein and dorsally migrating outside of the cardinal vein. n=3. (B) At E12.5, maximal intensity projection images of 100 µm cross-sections reveal first impairments in lymphatic structures labeled for PROX1 and VEGFR3. Below, quantification of VEGFR3+ lymphatic vasculature in the most dorsal region of the back. n=3. Dotted line represents the edge of the embryo

ALT Figure 2A-B: Lack of Osr1 in mesenchymal cells leads to lymphatic vasculature defects. (A) Maximal intensity projection images of Osr1+/+ and Osr1GCE/GCE E11.5 100 µm cross-sections after immunofluorescence. Immunolabeling for PROX1, VEGFR3 and PECAM1 shows normal commitment and delamination of LECs and normal blood endothelial structures in the dorsal part of the cardinal vein. Below, quantification of PROX1+ nuclei inside of the cardinal vein and dorsally migrating outside of the cardinal vein. n=3. (B) At E12.5, maximal intensity projection images of 100 µm cross-sections reveal first impairments in lymphatic structures labeled for PROX1 and VEGFR3. Below, quantification of VEGFR3+ lymphatic vasculature in the most dorsal region of the back. n=3. Dotted line represents the edge of the embryo

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New paper: we show a role for our favorite transcription factor Osr1 in our favorite #stromal cells to non cell autonomously regulate #lymphangiogenesis Out now in @Dev_journal doi.org/10.1242/dev.202747

Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation

Summary: Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation by controlling extracellular matrix and guidance signaling molecules.

journals.biologists.com
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Loss of Osr1 leads to altered matrix deposition impairing proliferation of lymph endothelial cells (LECs) at the sprouting tip, while decreased expression of signaling factors as Cxcl12 impairs LEC migration.
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Great @FUBiochemistry retreat today; proud of my group, especially Hafsa Zahid winning the poster prize!
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StrickerLab retweeted
Kairo
@Kairo_Anatomika22 Feb 2024
So...Mammals normally store fat under the skin in an even layer, but camels evolved to pile fat in one spot, so the rest of their bodies can stay cool in the desert. Why don't other desert animals do this? Well, they do.... but for some reason, we never talk about them..... 🧵🧵
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Hey #myotwitter! Enjoy this week’s papers on the regulation of skeletal muscle. It features metabolism, sarcopenia, dystrophy, development, exercise, and more. 👇 biomed.news/bims-moremu/2024… Highlighting work from @ValFajardoPhD @SamMathew_RCB @StrickerLab Thanks @Bims_BiomedNews
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New preprint from @LeGrandLab1 @GarciaPaulineJ : Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation biorxiv.org/content/10.1101/…

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and...

Modulations in chromatin structure orchestrate gene expression and direct stem cell fate. More specifically, the histone 3 lysine 9 Methyltransferase Setdb1 controls transcriptional repression to...

biorxiv.org
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It’s finally out!!! Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors rdcu.be/dyHzY Congratulations to @Xiao_yan_Wei, now postdoc @LaszloNagyLab
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This was coupled to premature muscle stem cell quiescence induction via Notch pathway activation; blunting Notch signaling during early postnatal development ameliorated the muscle phenotype in this model.
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While studies as these are only a very small step towards providing treatment to patients suffering from complex diseases as NF1, we hope this contributes to the understanding of an important phenotypic facet of NF1 @nfnetwork @NFibromatosis @neurofibroma_uk @ChildrensTumor
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So cool! From our @FU_Berlin @fubcp @FUBiochemistry neighbors @ewers_helge: An open-source, high resolution, automated fluorescence microscope biorxiv.org/content/10.1101/…

An open-source, high resolution, automated fluorescence microscope

Fluorescence microscopy is a fundamental tool in the life sciences, but the availability of sophisticated equipment required to yield high-quality, quantitative data is a major bottleneck in data...

biorxiv.org
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StrickerLab retweeted
Ewerslab@ewers_helge27 Jun 2023
New on BioRxiv: Adhesion energy controls lipid-binding mediated endocytosis. A group effort lead by @RaluucaG with contributions from our friends @taraskalab @DimovaLab @cmatthaeus2 and Thomas Weikl @MpiciPotsdam @FUBiochemistry @FU_Berlin biorxiv.org/content/10.1101/…

Adhesion energy controls lipid binding-mediated endocytosis

Several bacterial toxins and viruses can deform membranes through multivalent binding to lipids for clathrin-independent endocytosis. However, it remains unclear, how membrane deformation and...

biorxiv.org
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Our manuscript is officially accepted 🍾! Terrific collaborative effort with @bdcosgrove @dwmckellar Marie-Ange Renault & David Hammers. How do #cilia & ciliary hedgehog signaling balance intramuscular fat & muscle regeneration -> nature.com/articles/s41467-0…. #myotwitter @UFMedicine
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Does shape matter more than size when it comes to age-related myofibre changes? Full credit to Casper @Soendenbroe for his determination to convince me there might be something in this💪 @AndersKarlsen19 @ISMCopenhagen @MYOTWlTTER biorxiv.org/content/10.1101/…

Marked irregular myofiber shape is a hallmark of human skeletal muscle aging and is reversed by...

Background Age-related loss of strength is disproportionally greater than the loss of mass, suggesting maladaptations in the neuro-myo-tendinous system. Myofibers are often misshaped in aged and...

biorxiv.org
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