@RueggLab

Research Group of Prof. Markus A. Rüegg @biozentrum @UniBasel_en performing research on #Muscle Diseases #SkeletalMuscle #Aging #mTOR #LAMA2 #MDC1A #NMJ

 Basel, Switzerland
biozentrum.unibas.ch/research/researchgroups/overview/unit/rueegg/
Joined May 2019
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  • Following89
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Excited to share that our latest collaboration is published in @CellChemBiol! This study led by the Herbst Lab mapped the MuSK-associated proteome and identified Rapgef1 as a new player in NMJ signaling and postsynaptic maintenance. doi.org/10.1016/j.chembiol.2… @biozentrum
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Thank you for highlighting our study as Editor's choice, @MatrixBiology! We hope this work helps advance understanding of MTJ stability and its role in LAMA2-MD. doi.org/10.1016/j.matbio.202…
ASMB@amsocmatbioMar 24
We are pleased to announce the first selection for the @MatrixBiology Editor’s Choice feature. “Laminin-α2 is required for the maintenance of the myotendinous junction in vivo” @JuliaSchedel, Shuo Lin, Thomas Bock, Dominik Burri, and Markus rüegg sciencedirect.com/science/ar…
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LAMA2-related muscular dystrophy is a rare genetic disease for which there is currently no treatment available. We are happy to share our recent publication in Molecular Therapy, where we describe a unique linker-mediated gene therapy approach . doi.org/10.1016/j.ymthe.2026…
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Stem cell-derived laminin-α2 is crucial for muscle regeneration & reveals impaired stem cell function underlies LAMA2 muscular dystrophy 📷 Timothy J. McGowan et al @RueggLab @biozentrum in @NatureComms ➡️ bpod.org.uk/archive/2026/1/2… with @AntDLewis
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We're delighted that two of our publications have been shortlisted among these great papers. If you enjoyed our work, you can vote with the link below:
Matthew S. Alexander@Matt_Muscle_Guy1 Dec 2025
It is that time again, time to vote for the 12th Annual Matt's Totally Biased (but less so) Top 10 Muscle Papers of the Year. Due to prohibitive shipping costs, this year’s winner will receive an e-gift card in lieu of a plaque. Voting will end Dec. 20. uab.co1.qualtrics.com/jfe/fo…
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Check out our latest publication in @NatureComms, where we show that activated muscle stem cells remodel their niche with laminin-α2, and that the loss of this process intrinsically impairs their regenerative capacity in LAMA2-related muscular dystrophy: doi.org/10.1038/s41467-025-6…
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We’re excited to launch our Research Highlight Series! First up: an in-depth Q&A with Dr. Daniel Ham from @RueggLab on his latest @NatureComms paper, and insight into muscle biology, research, and more. #myotwitter Interview aurorascientific.com/researc… Paper nature.com/articles/s41467-0…
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In our latest preprint, we show that activated muscle stem cells secrete laminin-α2 into their niche — and that the loss of this process intrinsically impairs their regenerative capacity in LAMA2-related muscular dystrophy: doi.org/10.1101/2025.06.23.6…
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New study by @RueggLab challenges previous view about the muscle growth factor #Myc! This protein is dispensable for #musclegrowth. High Myc levels disrupt muscle fiber structure and function. @UniBasel_en @snsf_ch @NatureComms ow.ly/mXQm50VzRkP

New insights challenge previous views about a muscle growth factor

The protein Myc has long been thought to support skeletal muscle growth. Prof. Markus Rüegg's team at the Biozentrum provides compelling evidence that Myc in muscle fibers is dispensable for muscle...

biozentrum.unibas.ch
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Myc and muscle growth: necessary in muscle stem cells, dispensable in muscle fibers and harmful if overexpressed. Check out our latest work rdcu.be/eggcw in @NatureComms, where we explore the role of Myc in muscle growth and more.
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If you're using AAVs to develop a gene therapy or to study gene function in skeletal muscle, then this may be of interest to you. In our latest work, we show that AAVs commonly used to deliver transgenes to muscle fibers also target mononuclear cells: cell.com/molecular-therapy-f…
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Check out our latest publication where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: nature.com/articles/s41467-0… The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in...

Nature Communications - Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which...

nature.com
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It was great to host @TelethonSuisse in our lab and share insights into our research on LAMA2 muscular dystrophy (in French) @swiss_muscle @SEAL_Tx Reportage sur deux laboratoires de recherche à Bâle youtu.be/Gt4Zqpr_ZDg?si=5Uxn… via @YouTube #LAMA2 #MDC1A
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Really happy to share our study on Myotonic Dystrophy Type 1 now in #SkeletalMuscle. Very proud of the work performed by Denis Falcetta, @sandrinequirim, Florent Chabry, and all other group members and collaborators @unige @biozentrum. Thanks to all ! skeletalmusclejournal.biomed…

CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy...

Skeletal Muscle - Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs) deteriorate in skeletal...

link.springer.com
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Check out our latest preprint where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: biorxiv.org/content/10.1101/… The paper also characterizes three novel NMJ proteins including the Golgi-associated and MuSK-binding protein PDZRN4.
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On #RareDiseaseDay, we are putting the spotlight on LAMA2 muscular dystrophy. As yet, there are no effective therapies for this genetic disease. @SEAL_Tx, a @unibasel_en start-up, is now pursuing a promising approach. 🧵 1/7 unibas.ch/en/News-Events/New…

The best hope for children with a rare muscle disease might just be a SEAL

The diagnosis is followed by despair — then maybe a glimpse of hope. When parents of a child with the genetic disease LAMA2-related muscular dystrophy search around online, one of the things they...

unibas.ch
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Zum #TagDerSeltenenKrankheiten rücken wir die LAMA2-Muskeldystrophie in den Fokus. Bislang gibt es keine Therapie für die genetisch bedingte Erkrankung. @SEAL_Tx, ein Start-up der @unibasel, verfolgt nun einen vielversprechenden Ansatz. 🧵 1/6 unibas.ch/de/Aktuell/News/Un…

Seltene Muskelkrankheit: Seehund hilft Lama

Der Diagnose folgt Verzweiflung, dann vielleicht doch Hoffnung: Wenn Eltern eines Kindes mit der genetisch bedingten LAMA2-Muskeldystrophie im Internet suchen, stossen sie unter anderem auf SEAL...

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Be part of our pioneering efforts towards #bioxolography and join our new SNF Sinergia consortium with the research groups of Robert Katzschmann @srl_ethz (@ETH_en), Markus Rüegg @RueggLab (@UniBasel), and Matteo Moretti (@EnteOspedaliero). Revolutionize bioprinting with us!
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Replying to @RueggLab
@RueggLab has developed a new method using #CRISPR/Cas9 to study the function of genes in muscle fibers. It is efficient and reduces the number of experimental animals. The method implements the #3R principles. @biozentrum @UniBasel_en @NatureComms ow.ly/vBZt50PVSVq

Win-win in muscle research: faster results and fewer laboratory animals thanks to new method

To study muscle diseases, scientists rely on the mouse as a model organism. Markus Rüegg's research group at the Biozentrum, University of Basel, has now developed a new method that is not only...

biozentrum.unibas.ch
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Win-Win in der Muskelforschung: Forschende @biozentrum haben eine Methode entwickelt, die die Zahl der benötigten Versuchstiere stark reduziert. #Forschungsethik #CRISPR #3R unibas.ch/de/Aktuell/News/Un…

Win-Win in der Muskelforschung: schnellere Ergebnisse und weniger Versuchstiere dank neuer Methode

Um Muskelerkrankungen zu erforschen, sind Wissenschaftlerinnen und Wissenschaftler auf Mäuse als Modellorganismus angewiesen. Forschende der Universität Basel haben nun eine neue Methode entwickelt,...

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