@sebroemer.bsky.social Clinician Scientist at Franzmeier-Lab ISD; Resident Physician in Neurology at LMU Munich; Max Planck School of Cognition PhD
München, Bayern
Joined February 2013
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Sebastian Roemer-Cassiano retweeted
1/11 Our new paper is out in Alzheimer’s & Dementia! 🚨
Does cortical excitation–inhibition (E/I) imbalance link amyloid pathophysiology to memory? We tested this in non-demented older adults (cognitively normal + MCI) across two independent cohorts. 🧵👇
doi.org/10.1002/alz.71891
Many thanks to the @HAIconference committee and Maria Carrillo for recognizing the importance of our work with the HAI Travel Fellowship and the AAIC/ISTAART Fellowship—my surprise is clearly written all over my face. An amazing finale to a very interesting conference
Sebastian Roemer-Cassiano retweeted
Out now in Brain: Our new study co-led by @matbrendel shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/artic…
1/ What a session. I believe I saw people sleeping in front of the door to get a seat in the first row when doors opened!
Thanks to #AAIC25 for giving us the opportunity to organize this FRS, and thanks to everyone who came and participated in the cool discussion!
2/ and thanks again to our FRS team for the great talks and organization @fislarissa @HeidiJacobsLab @anne_maass Arnold Bakker, Yu Xiao, Jessica Peter, Bill Jagust and @nfranzme
1/3: Whether you are in Toronto to attend #AAIC25 or visiting the birthplace of Neil Young and Drake – make sure to not miss our Symposium on “Network alterations and aberrant neuronal activity in Alzheimer's disease” on Wed., July 30, 2:00 PM
2/3: Innovative topics by Yu Xiao, @fislarissa, @HeidiJacobsLab, Jessica Peter, Arnold Bakker and myself are awaiting you, chaired by @anne_maass and Bill Jagust. It was great fun organising this FRS and I am looking forward to some interesting discussions.
3/3: Also don’t miss our other FRS on tau heterogeneity in AD on Mon., July 28, 2:00 PM, chaired by @nfranzme and @_JakeVogel_, with talks by Zeyu Zhu and Anna Steward, and all the great posters of our lab by Madleen Klonowski, Lukas Frontzkowski, Fabian Hirsch and Amir Dehsarvi.
Always great pleasure to work with you @ZShaoshi and congrats again to you, @csabaorban, @Leon_Oo1 and @bttyeo for this very cool study!! I hope ours is next 🤞🏻
Special shoutout to @csabaorban and @Leon_Oo1 for co-leading this work! Huge thanks to @nfranzme, @SebRoemer and all our collaborators for contributing their invaluable datasets! Truly an amazing joint effort!
Sebastian Roemer-Cassiano retweeted
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s00259-025-0…
Sebastian Roemer-Cassiano retweeted
Happy to share new work by Carla Palleis in @movedisorder, showing that brain networks route neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds.30257
Sebastian Roemer-Cassiano retweeted
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠
🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this survey: alz.surveymonkey.com/r/923BT…
🚨Calling all neuroimagers! Help @EmmaCoomans shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th.
act.alz.org/site/R?i=eOejFv9…
Sebastian Roemer-Cassiano retweeted
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s13024-025-0…
Many thanks to the ADPD2025 committee for recognizing our work with @nfranzme on the effects of amyloid-induced hyperconnectivity on tau spreading! If you are enjoying a Gösser Radler and a Sacher Torte in Vienna, don't miss ADPD and my talk in Hall C at 10:00 on Wed 02.04.25
Sebastian Roemer-Cassiano retweeted
de Bruin et al. report that traumatic brain injury alters amyloid-β and tau deposition, with increased accumulation in fronto-parietal regions, & disrupts amyloid-tau coupling. Please read at: buff.ly/437ElwX @deBruin_Hannah @Colin__Groot @RikOssenkoppele @nfranzme
Thanks to @NatRevNeurol for highlighting our latest work on amyloid-induced hyperconnectivity and how it promotes tau spread! Can’t wait for the next studies to describe this novel mechanism more in detail and maybe even tackle it therapeutically!? Exciting times
Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease | Science Translational Medicine science.org/doi/10.1126/scit…
Sebastian Roemer-Cassiano retweeted
What’s the relationship between #AmyloidBeta and tau protein?
New research involving #AlzheimersDisease patient PET and fMRI data reveals amyloid-beta may drive tau spread through hyperconnectivity between vulnerable brain regions. @nfranzme @SebRoemer scim.ag/3CfY6aR
Nice to see @alzforum covering our most recent article in @ScienceTM and highlighting its importance for future lines of research and therapy! Special thanks @DavidJonesBrain and Tarick Pascoal for the great comments on our work!
alzforum.org/news/research-n…
Sebastian Roemer-Cassiano retweeted
This week's issue of #ScienceTranslationalMedicine is out now!
A new transplant protocol extends the survival of heart transplants in large animals, researchers explore emerging horizons in the use of hypoxia to treat chronic conditions, and more. scim.ag/3EiZjhW
So cool to finally see this project published in @Science TM. The idea came from clinical observation and ripened over many discussion with the best PI @nfranzme one can imagine. A new mechanism linking amyloid and tau, let’s explore it further and target it therapeutically!
Incredibly happy and proud to share our newest work in @ScienceTM showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to to first authors @SebRoemer and Fabian Wagner!
science.org/doi/10.1126/scit…
Thread below
No research can be done without the support of many people: @matbrendel @M_Malpetti @AnnaDewenter @AnnaSteward_ @amirdehsarvi , @JekyllSarah ,co-author Fabi Wagner and so many more - thank you all for the input and constant support, let’s keep it going!