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Roepman Lab (@RoepmanLab) profile picture

Roepman Lab

@RoepmanLab

Welcome to the account of the Roepman Lab (operated by members of the group). We study the molecular biology of cilia and ciliopathies.

 Nijmegen
roepmanlab.com
Joined April 2020
  • Tweets216
  • Following166
  • Followers394
4Media
Photo by Roepman Lab (@RoepmanLab)Photo by Roepman Lab (@RoepmanLab)Photo by Roepman Lab (@RoepmanLab)Photo by Roepman Lab (@RoepmanLab)
Roepman Lab retweeted
J Cell Science (@J_Cell_Sci) profile picture
J Cell Science@J_Cell_SciAug 10
Kae Whiting @Kae_Whiting, Ronald Roepman @roepmanlab and colleagues discover that loss of INPP5E affects photoreceptor outer segment membrane biogenesis in iPSC-derived human retinal organoids. journals.biologists.com/jcs/… #OpenAccess #ReadandPublish
Figure showing actin and tubulin dysregulation in d230 INPP5ED477N/D477N organoids.

ALT Figure showing actin and tubulin dysregulation in d230 INPP5ED477N/D477N organoids.

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Roepman Lab retweeted
Syncell Inc (@SyncellInc) profile picture
Syncell Inc@SyncellInc9 Jul 2025
Microscoop is live in Nijmegen! A big thank you to the @RoepmanLab and the Syncell team for an exciting and productive week of installation, training, and scientific exchange! From biovalidation to imaging and seminar discussions, the enthusiasm was contagious. #Microscoop
Image from Syncell Inc (@SyncellInc)
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Roepman Lab retweeted
CilNetNL (@CilNetNL) profile picture
CilNetNL@CilNetNL2 Apr 2025
🗓️ Save the date: CilNetNL meeting about therapy 💊 -Saturday 1-11-2025 in the UMC Utrecht- Program and registration link will be available soon. We hope to welcome many of you! Organized by Marijn Stokman, @RoepmanLab @GiselaSlaats #cilia #ciliopathy
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Getting ready for some cool spatial protein scooping with @JungChiLiao1 and @RORPMN
Image from Søren T. Christensen (@t_soren)
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We could not be happier for you Csenge! And very honored to have been part of this beautiful work!!
Csenge Rezi (@csenge_rezi) profile pictureCsenge Rezi@csenge_rezi8 Jun 2024
Excited to share my very first first-author publication on @emboreports! ✅🥳 Thanks again to everyone who contributed to this project and made it happen! embopress.org/doi/full/10.10…
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Cilia tweeps can anyone recommend an antibody against a centrosome marker that is NOT raised in rabbit or mouse but works reliably???
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News from the Nephrolab! Our 1st preprint on BBS: Cystic kidney disease in Bbs8 and possible mechanisms. THANKS to Helen May-Simera & her team & everyone else who contributed! biorxiv.org/content/10.1101/… #BBS #Ciliopathy #RareDisease #Nephrology #Nephrolab #Cilia @UKKoeln @CECAD_
Loss of Bbs8 leads to cystic kidney disease in mice and affects tubulin acetylation through HDAC2

Loss of Bbs8 leads to cystic kidney disease in mice and affects tubulin acetylation through HDAC2

Bardet-Biedl Syndrome (BBS) is a genetic disorder marked by considerable genetic and phenotypic diversity. BBS often presents as a combination of retinitis pigmentosa, obesity, polydactyly, and...

biorxiv.org
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Hey #nephrology aficionados: Are you interested in achieving nanoscale (<50nm) level resolution of organelles, cytoskeletal components, and other subcellular structures? Would you like to avoid doing electron microscopy? Then let me tell you how 👇 biorxiv.org/content/10.1101/…
Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular...

Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular...

Ultrastructure expansion microscopy (U-ExM) involves the physical magnification of specimens embedded in hydrogels, which allows for super-resolution imaging of subcellular structures using a...

biorxiv.org
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Roepman Lab retweeted
Reiter Lab (@ReiterLab) profile picture
Reiter Lab@ReiterLab16 Feb 2024
New cilia signaling review written with @Hilgendorf_Lab and @Myers_lab and expertly edited by @lisa_heinke! Please read and give feedback. We tried to highlight existing barriers to progress, experimental innovations that might overcome them, and exciting future directions.
Nature Reviews Molecular Cell Biology (@NatRevMCB) profile pictureNature Reviews Molecular Cell Biology@NatRevMCB16 Feb 2024
Now Online Emerging mechanistic understanding of cilia function in cellular signalling dlvr.it/T2r8vD
Image from Nature Reviews Molecular Cell Biology (@NatRevMCB)
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We are hiring! We are currently hiring a talented and highly motivated postdoctoral researcher for a 2-year position on primary cilia and brain development in health and disease. candidate.hr-manager.net/App…
Image from Søren T. Christensen (@t_soren)
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Roepman Lab retweeted
Alex Garanto (@Jandritu) profile picture
Alex Garanto@Jandritu18 Dec 2023
We have a new Doctor in town! Congrats Dr. Faber! Very well-deserved degree and excellent public defense! @RoepmanLab @collinrwj and I are very proud! Now time to enjoy! @radboudumc_weet @GeneticNijmegen #phd
Image from Alex Garanto (@Jandritu)
Image from Alex Garanto (@Jandritu)
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Just under 9 months to go to Cilia2024 on Sept 10-13, so save the date. Fantastic program and speakers lined up - check us out at cilia2024.ie. Registration opening in February.
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Thanks a lot to my co-organizers @marijnstokman @RORPMN! Let’s keep going like this 🤩
CilNetNL (@CilNetNL) profile pictureCilNetNL@CilNetNL13 Nov 2023
Fantastic CilNetNL kick-off meeting at the UMC Utrecht last Saturday! Connecting the community and sharing of cilia science. Thanks to all participants for making it a great success!
Image from CilNetNL (@CilNetNL)
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1/3) I'm absolutely thrilled to share my very first #preprint! 🥳I couldn't have done it without the help of my fantastic supervisor @LottePedersen12 and all the amazing contributors, so a huge thank you to everyone involved! biorxiv.org/content/10.1101/…
DLG1 functions upstream of SDCCAG3 and IFT20 to control targeting of polycystin-2 to the primary...

DLG1 functions upstream of SDCCAG3 and IFT20 to control targeting of polycystin-2 to the primary...

Polarized vesicular trafficking directs specific receptors and ion channels to the primary cilium, but the underlying mechanisms are poorly understood. Here we identify a key role for discs large...

biorxiv.org
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Yesterday was the first day of TheRaCil's project Kick Off Meeting in Copenhagen. What a pleasure to meet all the partners for scientific discussions and moments of sharing ! 🇪🇺 #TheRaCil #Ciliopathy #Cilia #Research #EC
Image from TheRaCil Project (@TheRaCilProject)
Image from TheRaCil Project (@TheRaCilProject)
Image from TheRaCil Project (@TheRaCilProject)
Image from TheRaCil Project (@TheRaCilProject)
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Werken aan de ontwikkeling van therapieën voor kinderen met een nier-ciliopathie? @Radboudumc doet het in het internationale TheRaCil-project, gefinancierd door de Europese Commissie #Horizon @Radboud_Uni @RoepmanLab radboudumc.nl/nieuws/2023/th…

Therapieën ontwikkelen voor kinderen met erfelijke nierziekten - Europees TheRaCil-project bundelt...

5 oktober 2023

radboudumc.nl
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The first publication from our #FOR5547 - review about primary #cilia dynamics @jayslab2 @MickLab @NathalieJuYa @RosiFeistel @WalentekLab @BernhardScherm1 @anne_grapin @friedrich_group @lab_mass @muellerRom @helenmaysimera embopress.org/doi/full/10.15…
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Thrilling times! Today marked the electrifying pre-kickoff of WP 2 of @theracil in Cologne! Fruitful marathon discussions propelling us forward with absolute clarity! Ready, set, let the journey commence! 🚀🎉 #TheraCil #Ciliopathy #RareDisease #Collaboration #science #Cilia
Group photos of today's meeting participants, top picture taken after the coffee break, bottom picture during the evening wrap-up. A huge THANK YOU to everyone who journeyed to Cologne or powered up zoom to join us!

ALT Group photos of today's meeting participants, top picture taken after the coffee break, bottom picture during the evening wrap-up. A huge THANK YOU to everyone who journeyed to Cologne or powered up zoom to join us!

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Interested in working on primary #cilia signaling funded by @NSF @dfg_public, combining genetics, proteomics, optogenetics at @TamaraGenes @MickLab @DagmarWachten ? Apply now! Our labs have open calls for a #PhDposition and a technician. Please get in touch if you are interested!
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The endogenous capacity of the kidney to repair is limited, & generation of new nephrons after injury remains a need. Read this Review of kidney regeneration, including pre-clinical methodologies used to elucidate regenerative pathways. #OpenAccess link.springer.com/article/10…
Image from Pediatric Nephrology (@Ped_Neph)
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