@MickLab

Using biochemistry, cell biology, proteomics and imaging techniques to unravel the molecular functions of mammalian primary #cilia. @mick-lab.bsky.social

 Homburg, Germany
mick-lab.com
Joined July 2020
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  • Followers572
9Media
We are super-excited to see our first original paper published in @JCellBiol. Fantastic collaboration with @KalocsayMarian @GygiLab @MaxNACHURY to establish quantitative, time-resolved #cilia #proteomics. Very proud of our first PhD student Elena May! rupress.org/jcb/article/220/…
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Hundreds of scientists who study cancer and aging have made an easily avoidable but significant mistake, deploying the wrong antibody to test for a key protein, according to a researcher who exposes errors in the biomedical literature. Learn more: scim.ag/4akPaP4 @NewsfromScience
Protein name confusion created antibody mix-up affecting hundreds of papers

ALT Protein name confusion created antibody mix-up affecting hundreds of papers

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.@CytoLabKoc show PCM1 multimerization scaffolds centriolar satellite assembly & drives stepwise client recruitment. Disrupting this homeostasis impairs ciliary signaling & #mitosis. Key insights into how this membraneless organelle forms & remodels hubs.la/Q04l3fVz0
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We are very proud of our @Saar_Uni B.Sc. student Smilla Koy for winning the Euro #Cilia2027 image competition. A well-deserved recognition of her amazing work. We're lucky to have such talent in the lab!
7th European Cilia Meeting@EuroCilia2027
Jun 5
🏆 GRAND PRIZE WINNER 🏆 Congrats to Smilla-Maria Koy (BSc Student, Mick Lab, Saarland University, Germany) for winning our Image Competition! 🔬 "IMCD3 Spheroid with Cilia" captures primary cilia emerging into the lumen to show cell polarity. #FluorescenceFriday #cilia.
Confocal image of a hollow spheroids with apical ZO-1 signal and primary cilia emerging from the apical site pointing towards the lumen. This 3D technique is used to assess apicobasal polarity characteristics in cells, where primary cilia play an important role in establishment and maintenance.

ALT Confocal image of a hollow spheroids with apical ZO-1 signal and primary cilia emerging from the apical site pointing towards the lumen. This 3D technique is used to assess apicobasal polarity characteristics in cells, where primary cilia play an important role in establishment and maintenance.

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A PhD's success depends more on the fit between the student, the advisor, and the lab than on the specific topic being studied (it barely matters at all). Similarly, a lab's success depends more on how excited (or miserable) its researchers are than on the precise project they are working on (it could be virtually anything). This information isn't in papers or in grant proposals, you have to ask the researchers.
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This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. elifesciences.org/reviewed-p…
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I am thrilled to be featured in the ‘First Persons’ through the decades article in Journal of Cell Science.. It is honoring for me to appear on the same page as David Stephens, an outstanding scientist, leader, and mentor in the cilia field, who sadly passed away in 2024.
J Cell Science@J_Cell_Sci
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Our ‘First Person’ series was launched in 2017 to highlight the first authors of our Research Articles. In this ‘First Persons through the decades’ article, Amelia Glazier highlights some notable scientists who have published first-author papers in JCS. journals.biologists.com/jcs/…
Photos of Honor Fell, Karm Bahl, Peter Medawar, Jean Hanson, Irène Manton, Linda Amos, Juan Bonifacino, Chiara Zurzolo, David Stephens, Elif Nur Firat-Karalar. Text: 'First Persons' through the decades - 100 years of notable scientists in Journal of Cell Science

ALT Photos of Honor Fell, Karm Bahl, Peter Medawar, Jean Hanson, Irène Manton, Linda Amos, Juan Bonifacino, Chiara Zurzolo, David Stephens, Elif Nur Firat-Karalar. Text: 'First Persons' through the decades - 100 years of notable scientists in Journal of Cell Science

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A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery. elifesciences.org/articles/9…
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Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.
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First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science. A few benches are still waiting for curious minds: Come, join us! #AcademicJob
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"For half an hour, I vented everything I had been holding in for months … my supervisor listened patiently, then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." #ScienceWorkingLife scim.ag/47vf7L6
An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

ALT An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

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The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard
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More on collective behavior: Our new Annual Review of Biophysics piece - with the stellar Danielle Chase - explores how animals sense, share information, and make group decisions. In honeybees and beyond 🐝 annualreviews.org/content/jo…
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I think a good rule of thumb is to spend at least as much time thinking about your data as you did obtaining it. It's common for people to spend a lot less time thinking than doing which gives rise to all kinds of problems.
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A new paper reports that the primary mechanism of capsaicin entry into the vanilloid-binding site of TRPV1 is a targetable hydrophobic tunnel at the TRPV1-membrane interface nature.com/articles/s41589-0…

Mechanism of capsaicin entry into buried vanilloid sites in TRPV1

Nature Chemical Biology - The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable...

nature.com
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Militsin, Palty et al. reveal novel crosstalk btwn STIM proteins & IP3Rs, whereby STIM activation alters the spatial pattern of IP3R-mediated Ca2+ release, shifting it from a promigratory localized signal to a diffuse, migration-suppressing signal hubs.ly/Q03z58_80
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Save the date! March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳 Stay tuned for more info!
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👨‍🎓 🇩🇪👩‍🎓 Further your research career by doing your PhD in Germany❗ Start your search for currently open PhD positions at the DAAD online database PhDGermany.de
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The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching. Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025! @EMBO @Co_Biologists meetings.embo.org/event/25-l…
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Save the date dear #cilia #centrosome fans🙂 The 8th Czech Cilia meeting will happen this year in Brno on 17th of June with keynote speaker Ruxandra Bachmann-Gagescu. No registration fees👏please RT🌼
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Huo, Wang et al. reveal that #adipocytes experiencing endoplasmic reticulum stress secrete #ceramide in lipoprotein form to #hepatocytes, activating the unfolded protein response by reducing membrane fluidity. hubs.ly/Q03dw31h0 #ER_literature
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