@RobertoDeF_

Neuroscience post doc (first gen) @HumboldtUni ℙ𝕀π•ͺπ•”π•™π•–π••π•–π•π•šπ•”π•€, ５－ＨＴ, πŸ„β€β™‚οΈ, ⚽️ and 🎸

 Berlin
github.com/RobertoDF
Joined February 2014
  • Tweets259
  • Following1.2K
  • Followers5.3K
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1/ Thrilled to share the first work from the Ott lab (@OttTorben), with OpenScope at @AllenInstitute! We focused on how #psilocybin πŸ„changes visual processing during active behavior in mice. We combined visual change detection with large-scale Neuropixels recordings in mice.
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Bertoglio lab (FMC/UFSC)@bertogliolabOct 15
5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin nature.com/articles/s41593-0…

5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic...

Nature Neuroscience - Psilocybin promotes and stabilizes new connections between neurons in the mouse cerebral cortex, especially after stress. Baker et al. show that 5-HT2A receptor signaling in...

nature.com
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Boris D Heifets
@TheBorisLabOct 6
Is AI conscious? I have no idea. But I'm excited to spend a week talking about problems in consciousness, disorders of consciousness, dreaming, delirium, perception that may actually be experimentally tractable πŸ˜… Apply now - space is limited! Links below
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This is certainly the most consequential paper published in child and adolescent psychiatry for the last few years. It shows that the meta-analyses that current child psychiatry guidelines rely on to recommend fluoxetine for depression were skewed by an unbelievable trial (n=40) in Iran which found an effect 15 times larger than the average. When this trial is removed all meta-analyses find the same as a recent Cochrane analysis which found 'small and unimportant differences.' The flawed meta-analyses by Zhou and @cipriani in the @TheLancet and Lancet Psychiatry need to be corrected. And guideline committees need to update their guidance in the context of the harms of these drugs including withdrawal effects, sexual effects and agitation/akathisia and suicidality in a minority of youths exposed to them. Link below
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Dr Joanna Moncrieff@joannamoncrieffOct 3
Guidelines should stop recommending antidepressants for children with depression. The new analysis confirms what has been suspected for years that benefits of antidepressants, including fluoxetine, are minimal & will not compensate for known harms. onlinelibrary.wiley.com/doi/…

A Re‐Appraisal of Three Network Meta‐Analyses to Explain the Discrepancy in Findings for the...

Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recomm...

onlinelibrary.wiley.com
Mark Horowitz @markhoro.bsky.social
@markhoroOct 2
This is certainly the most consequential paper published in child and adolescent psychiatry for the last few years. It shows that the meta-analyses that current child psychiatry guidelines rely on to recommend fluoxetine for depression were skewed by an unbelievable trial (n=40) in Iran which found an effect 15 times larger than the average. When this trial is removed all meta-analyses find the same as a recent Cochrane analysis which found 'small and unimportant differences.' The flawed meta-analyses by Zhou and @cipriani in the @TheLancet and Lancet Psychiatry need to be corrected. And guideline committees need to update their guidance in the context of the harms of these drugs including withdrawal effects, sexual effects and agitation/akathisia and suicidality in a minority of youths exposed to them. Link below
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Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise (in mice) biorxiv.org/content/10.64898… by @RobertoDeF_ @OttTorben et al.

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise

Psilocybin profoundly alters visual perception, yet the neuronal mechanisms underlying these effects remain unclear. Here we combined large-scale Neuropixels recordings with cell-type-specific...

biorxiv.org
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Too many neuro preprints to keep track of, so I made a monthly ranking of the most-read ones on bioRxiv. Not a measure of quality, just what people are reading. Here's the fresh ranking for September: robertodf.github.io/biorxiv-…
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created a website to convert any DOI to a elegant banner for presentations robertodf.github.io/doi-bann…
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Roberto De Filippo retweeted
Jordan Hamm@HammJordanSep 13
Our paper is out now in Neuropsychopharmacology! 🧡 nature.com/articles/s41386-0… @anna_3anana @drchloewest @neuroConnG @JessicaLBolton @oigeorgia @FumiyasuImai

Mismatch negativity matures in adolescence and without sensitivity to microglial depletion

Neuropsychopharmacology - Mismatch negativity matures in adolescence and without sensitivity to microglial depletion

nature.com
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Husk
@huskirlSep 14
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Bertoglio lab (FMC/UFSC)@bertogliolabSep 10
Why taking the trip out of psychedelic medicine is a mistake doi.org/10.1016/j.drugpo.202…
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BryanRoth
@zenbrainestSep 9
Cool! Neocortical long-range inhibition promotes cortical synchrony and sleep nature.com/articles/s41586-0…
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4/ Our findings point to a previously unrecognized role for SST interneurons in the acute psychedelic state, potentially linking altered surprise signals to visual distortions. A huge thank-you to the entire OpenScope team, especially @LecoqJerome, for making this work possible!
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5/ π•»π–˜π–Žπ–‘π–”π–ˆπ–žπ–‡π–Žπ–“ π–ˆπ–”π–‘π–‘π–†π–•π–˜π–Šπ–˜ π–›π–Žπ–˜π–šπ–†π–‘ π–ˆπ–π–†π–“π–Œπ–Š π–‰π–Šπ–™π–Šπ–ˆπ–™π–Žπ–”π–“ 𝖆𝖓𝖉 π–‰π–—π–Žπ–›π–Šπ–˜ π–ˆπ–”π–—π–™π–Žπ–ˆπ–†π–‘ π–‰π–žπ–“π–†π–’π–Žπ–ˆπ–˜ π–™π–”π–œπ–†π–—π–‰ 𝖆 π–˜π–™π–†π–™π–Š 𝖔𝖋 π–˜π–šπ–—π–•π–—π–Žπ–˜π–Š #Psychedelics #Neuroscience #PsychedelicScience biorxiv.org/content/10.64898…

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise

Psilocybin profoundly alters visual perception, yet the neuronal mechanisms underlying these effects remain unclear. Here we combined large-scale Neuropixels recordings with cell-type-specific...

biorxiv.org
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Davide Momi@DaveMomiAug 19
1/6 πŸ„ What happens in the brain under psilocybin? I’m excited to share our new preprint: β€œBrain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics.” biorxiv.org/content/10.64898… #Psilocybin #Psychedelics #Neuroscience #OpenScience
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4 years and 6 rounds of review later, our mega-entropy analysis is published in Nature Communications! Major points: most previously reported fMRI entropy metrics don't replicate, some do, and they have very little to do with each other, so be specific! xx nature.com/articles/s41467-0…

Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy

Nature Communications - Five of 14 fMRI brain entropy metrics tracked acute psilocybin effects in healthy humans across data denoising pipelines in this replication study. This research highlights...

nature.com
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ENcenatur@encenaturAug 12
Complex behavior from intrinsic motivation to occupy future action-state path space nature.com/articles/s41467-0…

Complex behavior from intrinsic motivation to occupy future action-state path space

Nature Communications - Intelligent behavior of artificial agents and their design are usually considered as a reward maximization phenomenon, however, the reward function construction may be...

nature.com
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BryanRoth
@zenbrainestAug 6
A suite of engineered mice for interrogating psychedelic drug actions #psychedelics Congrats to Yi-ting, Ariel, Bill, Gavin, Dewran, Pierre and too many others to mention. A yuuge effort and we hope that folks will find these mice useful nature.com/articles/s41593-0…

A suite of engineered mice for interrogating psychedelic drug actions

Nature Neuroscience - Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across...

nature.com
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