@PDClab

Laboratory of Pietro De Camilli - Department of Neuroscience at Yale University

 New Haven, CT
medicine.yale.edu/lab/decamilli/
Joined December 2018
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The De Camilli lab account has moved to Bluesky: PDC-Lab.bsky.social
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Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM biorxiv.org/content/10.1101/…

Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic...

Recent studies have identified a family of rod-shaped proteins which includes VPS13 and ATG2 and are thought to mediate unidirectional lipid transport at intracellular membrane contacts by a bridge...

biorxiv.org
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A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell–cell contacts rupress.org/jcb/article/223/…

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell–cell contacts

The ER-anchored lipid transfer protein TMEM24/C2CD2L and its paralog C2CD2 mediate the formation of ER–plasma membrane junctions at sites of cell–cell cont

rupress.org
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Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles biorxiv.org/content/10.1101/…

Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of...

Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive...

biorxiv.org
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Our new preprint reveals that the interaction of the bridge-like lipid transport protein VPS13A with the lipid scramblase XK at ER-plasma membrane contacts in K562 cells correlates with erythroid differentiation @ChaseAmos15 @YaleCellBio @YaleNeuro biorxiv.org/content/10.1101/…

Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562...

Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions...

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Our review on RBG motif bridge-like #lipid transport proteins of the VPS13-ATG2 family is now out in Annual Reviews of Cellular and Development Biology @AnnualReviews @YaleCellBio annualreviews.org/doi/abs/10…

RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and Open Questions

The life of eukaryotic cells requires the transport of lipids between membranes, which are separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the secretory and...

annualreviews.org
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Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology nature.com/articles/s41531-0…
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Our collaborative study with the Cao lab at Duke-NUS reporting the synergistic pathological defects of mutations in synaptojanin 1 (Synj1) and auxilin (DNAJC6), two Parkinsonism genes, is now published.
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Our paper demonstrating the segregation of synaptic vesicle proteins from ATG9 when expressed in fibroblastic cells, and their properties to be clustered in different condensates by synapsin, is now out in Nature Communications @YaleCellBio @YaleNeuro nature.com/articles/s41467-0…
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Check out the De Camilli lab at #CellBio2022! @ASCBiology @YaleCellBio
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On Tuesday, check out posters from Mick Park @Sophistarete about axonal transport and synapse formation (P2789; B403) and Daehun Park @eoqkr159 (P2807; B421) about synaptic vesicle phases,
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And finally on Tuesday, Michael Hanna’s @lifecerealmikey poster (P2715; B327) on lipid channeling proteins that control endocytic traffic and then his talk at the minisymposium on Membrane trafficking and Organelle Homeostasis at 430pm in room 146B.
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Our review for Cold Spring Harbor Perspectives in Biology on the role of lipid transport proteins at ER-contacts sites in neurodegenerative disease is now on line. cshperspectives.cshlp.org/co…
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Check out our lab's newest work from @HaniehFalahati! Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines @YaleNeuro @YaleCellBio pnas.org/doi/10.1073/pnas.22…

Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine...

The spine apparatus is a specialized compartment of the neuronal smooth endoplasmic reticulum (ER) located in a subset of dendritic spines. It cons...

pnas.org
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Our paper describing VPS13A interaction with XK at ER-PM contact sites is now out on PNAS: doi.org/10.1073/pnas.2205425… @AGuillenSaman @YaleCellBio @YaleNeuro @KavliAtYale

A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma...

Chorea-acanthocytosis (ChAc) and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectivel...

pnas.org
De Camilli Lab@PDClab31 Mar 2022
A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane biorxiv.org/content/10.1101/…
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Membrane remodeling properties of the Parkinson’s disease protein LRRK2 biorxiv.org/content/10.1101/…
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Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates biorxiv.org/content/10.1101/…

Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin...

Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like propert...

biorxiv.org
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