MIT '25 CS/Math

Joined June 2022
Ron Shprints retweeted
Commerce is about to look very different. We’ve spent the past year building Generative Commerce to finally bring the magic of generative AI directly to the consumer. Excited for the world to enjoy it! :) @daletlabs
Introducing Generative Commerce. @daletlabs
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Ron Shprints retweeted
Now coming to a #NeurIPS2026 near you as a Spotlight 🔦!
Protein–ligand cofolding models are getting incredibly powerful… but do they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: genesis.ml/news/genesis-mode… 🔗arXiv: arxiv.org/abs/2606.08375 Code (coming soon): github.com/genesistherapeuti…
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Ron Shprints retweeted
It’s getting hard to keep track of all the new open-source cofolding models coming out. To help everyone stay up to date, I'm excited to share cofoldarena.ai, a PDB-synced leaderboard of open models, updated weekly. All predictions are available to view & download! (1/4)
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Ron Shprints retweeted
Small model, looooong context Reverso is now improved to handle significantly longer contexts, up to 16k! We pretrain our foundation model to handle inputs at multiple frequency scales, and observe an improvement in forecasting performance while maintaining fewer than 3M params
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Ron Shprints retweeted
We're presenting DeCAF ☕️: A few-step cofolding model with all-atom flow maps at the GenBio workshop at #ICML2026 as a Spotlight in the morning poster session!! Also, we've now released the code and checkpoints from the paper: code🧑‍💻: github.com/genesistherapeuti… paper🔗: arxiv.org/abs/2606.08375 Come by and say hi 👋!
Protein–ligand cofolding models are getting incredibly powerful… but do they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: genesis.ml/news/genesis-mode… 🔗arXiv: arxiv.org/abs/2606.08375 Code (coming soon): github.com/genesistherapeuti…
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Hi everyone! I’ve moved to the Bay Area for a summer research internship at @nvidia. Beyond exciting work, I'd love to meet new people doing exciting stuff (incl. stuff I don't work on myself rn!). If you’re around, I’d love to connect! Even if just for a jam session!
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Ron Shprints retweeted
Big news from Boltz - our biggest update yet! 🚀 Today we’re releasing two new state-of-the-art models for protein and small molecule design with extensive wet lab validation and a new API to run all of our models on scalable GPUs wherever you (or your agents) work! 🔥
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Ron Shprints retweeted
extremely excited about this work bringing flow maps to cofolding -- check it out! by using flow maps, we not only have faster inference, but we obtain access to more powerful reward guidance & search techniques. these leverage an exact reward computation provided by the flow map, which is significantly more precise than more standard denoiser-based estimates
Protein–ligand cofolding models are getting incredibly powerful… but do they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: genesis.ml/news/genesis-mode… 🔗arXiv: arxiv.org/abs/2606.08375 Code (coming soon): github.com/genesistherapeuti…
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DeCAF is our first method for accurate distillation of all-atom cofolding diffusion models into fast flow maps. this can unlock a lot of practical applications of powerful models like Pearl, e.g., scalable synthetic data generation. very proud of this work, congrats to the team!
Protein–ligand cofolding models are getting incredibly powerful… but do they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: genesis.ml/news/genesis-mode… 🔗arXiv: arxiv.org/abs/2606.08375 Code (coming soon): github.com/genesistherapeuti…
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Ron Shprints retweeted
Protein–ligand cofolding models are getting incredibly powerful… but do they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: genesis.ml/news/genesis-mode… 🔗arXiv: arxiv.org/abs/2606.08375 Code (coming soon): github.com/genesistherapeuti…
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We got 2 big birds with one stone: 1) DeCAF-Pearl makes all-atom cofolding much faster than previously possible and 2) enables inference time search.⚡️ An incredible amount of work was done by a very talented team, and it was a pleasure to participate:)
Protein–ligand cofolding models are getting incredibly powerful… but do they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: genesis.ml/news/genesis-mode… 🔗arXiv: arxiv.org/abs/2606.08375 Code (coming soon): github.com/genesistherapeuti…
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Ron Shprints retweeted
Our Equivariant Deep Learning book is finally available for purchase as hardcover 📖 and it immediately became a bestseller 🚀 worldscientific.com/worldsci…
🚀 New Bestselling Book! The future of Geometric Deep Learning is here! Master Equivariant and Coordinate Independent Convolutional Networks through the groundbreaking Gauge Field Theory of Neural Networks. Build dramatically more data-efficient, robust, and powerful models.

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Very excited about this work! Language modeling via flow maps allows us to rethink how to build language models that do latent reasoning and fast generation! Glad to play my small part in a wonderful effort with @PPotaptchik, @json_yim, @adhisarav, Eric Vanden-Eijnden, @msalbergo!
New paper! Presenting Discrete Flow Maps: paper: arxiv.org/abs/2604.09784 blog: malbergo.me/discrete-flow-ma… A laughable problem for me these days is that @nmboffi and I share a research brain, and we have had, time and again, a conversation that ends with “ha so I guess we’re writing the same paper.” Soon we will return to just doing it together :). Here we are doing it again with discrete flow maps and flow language models! A complete and thorough paper led by @PPotaptchik @json_yim @adhisarav @peholderrieth. We took a bit of time to post it to ensure we understood a few more things about the stability of the loss functions. Like @osclsd , @FEijkelboom, and @nmboffi , we think this could be a very helpful paradigm for thinking about fast inference and even better alignment! Here’s our version of the story, and I hope it makes clear how green field this research direction is — we provide a comprehensive picture of the KL losses you can write from the properties of the flow map, some nice geometric proofs about the mean denoiser and the simplex, and find that at this time, the ESD can actually be the most performant, with some caveats. Excited for everyone to work together and push this class of models to their limit!
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Arriving in Rio 🇧🇷for #ICLR! I will present GLASS Flows + Diamond Maps in the coming days - starting today with GLASS Flows Oral at 11:30 AM! I am looking forward to meeting new people! Feel free to reach out! 1/3
We release Diamond Maps💎 unlocking accurate and efficient guidance for diffusion models. Our experiments show that our methods scale incredibly well. Excited to see what people will build with this! Accurate guidance has been a notoriously hard problem, but in this work, we’re bringing TWO (!) solutions to the table. The recipe for success: 1️⃣ Speed: Use distilled models (flow maps, mean flows, consistency models). 2️⃣ Exploration: Inject stochasticity to properly explore your search space. Because this fundamentally improves anything using flow matching and diffusion, we see a lot of potential for applications across audio, robotics, molecules, and beyond. Paper: arxiv.org/abs/2602.05993 Code: github.com/PeterHolderrieth/… Huge thanks to an amazing team: Douglas Chen, @LucaEyring, @ishin_shah, Giri Anantharaman, @electronickale, @zeynepakata, Tommi Jaakkola, @nmboffi, and @max_simchowitz. It was awesome bringing this to life together!
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RT @peholderrieth: We release Diamond Maps💎 unlocking accurate and efficient guidance for diffusion models. Our experiments show that our m…
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We are also releasing self-contained lecture notes that explain flow matching and diffusion models from scratch. This goes from "zero" to the state-of-the-art in modern Generative AI. 📖 Read the notes here: arxiv.org/abs/2506.02070 Joint work with @EErives40101.
🚀MIT Flow Matching and Diffusion Lecture 2026 Released (diffusion.csail.mit.edu/)! We just released our new MIT 2026 course on flow matching and diffusion models! We teach the full stack of modern AI image, video, protein generators - theory and practice. We include: 📺 Videos: Step-by-step derivations. 📝 Notes: Mathematically self-contained lecture notes 💻 Coding: Hands-on exercises for every component We fully improved last years’ iteration and added new topics: latent spaces, diffusion transformers, building language models with discrete diffusion models. Everything is available here: diffusion.csail.mit.edu/ A huge thanks to Tommi Jaakkola for his support in making this class possible and Ashay Athalye (MIT SOUL) for the incredible production! Was fun to do this with @RShprints! #MachineLearning #GenerativeAI #MIT #DiffusionModels #AI
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Recordings have just dropped on YouTube! You should definitely check out this amazing resource if you want to learn about flow matching. Peter is the best of the best and he put so much effort into this. It was a pleasure to contribute my small part:)
🚀MIT Flow Matching and Diffusion Lecture 2026 Released (diffusion.csail.mit.edu/)! We just released our new MIT 2026 course on flow matching and diffusion models! We teach the full stack of modern AI image, video, protein generators - theory and practice. We include: 📺 Videos: Step-by-step derivations. 📝 Notes: Mathematically self-contained lecture notes 💻 Coding: Hands-on exercises for every component We fully improved last years’ iteration and added new topics: latent spaces, diffusion transformers, building language models with discrete diffusion models. Everything is available here: diffusion.csail.mit.edu/ A huge thanks to Tommi Jaakkola for his support in making this class possible and Ashay Athalye (MIT SOUL) for the incredible production! Was fun to do this with @RShprints! #MachineLearning #GenerativeAI #MIT #DiffusionModels #AI
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Most people assume you need a massive dataset to distill flow models. We challenge that. Is data actually necessary? Or perhaps it is a liability? Introducing FreeFlow: We achieve SOTA (1.49 FID on ImageNet-512) 1-step image generation without a single data sample. 🧵👇[1/n]
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Ron Shprints retweeted
truly the greatest day ever🎗️
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Ron Shprints retweeted
New work led by @peholderrieth showing how to transform an already trained flow matching model to a stochastic transition/posterior model that can still be sampled via an efficient ODE solver!
New work: “GLASS Flows: Transition Sampling for Alignment of Flow and Diffusion Models”. GLASS generates images by sampling stochastic Markov transitions with ODEs - allowing us to boost text-image alignment for large-scale models at inference time! arxiv.org/pdf/2509.25170 [1/7]
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