@RSBon_Lab

moved to https://xitter.cf/t.co/cDzy1OLZK0

 UK
Joined October 2017
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Join @AstburyCentre at the Royal Society in London in April to explore how drug discovery may be taken towards cells and tissues! #cryoET #cryoEM #imaging #chemicalproteomics
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4 Cheney PhD scholarships available in in situ structural biology - bench to bedside @ScienceLeeds @Astbury_BSL @LeedsBRC @LeedsMedHealth @AstburyCentre astbury.leeds.ac.uk/cheney-p… apply by 3rd December
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Presented work and attended Brain Sciences Editorial meeting at the SFN 2024 with more than 30,000 delegates from all over the world- a great experience and knowledge transfer
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🧵I’ve read through the evidence section—the first 85 pages—of Jack Smith filing on Trump’s private criminal efforts to stay in power despite knowing that he’d lost the election. The evidence is stunning. It’s clear why Trump did not want the public to see this testimony. 13 things jumped out to me on Trump’s attempt to defraud the American people and steal the 2020 election.
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Penn is looking for an Assistant Professor in the broadly defined area of Biological Chemistry and Chemical Biology! Please spread the good news and retweet. @Penn @PennChemistry @PennMedicine @pennbioeng apply.interfolio.com/153352
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Robin Bon retweeted
Michael Baym@baym30 Dec 2018
If journal styles don’t allow Oxford commas, I’m sending my next three papers to Nature, a predatory journal and a scam publisher
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Join me in signing this petition for the UK to rejoin ERASMUS ...@DavidLammy @b_judah europeanmovement.co.uk/erasm…

This is Erasmus - Petition

We call on the Government to open negotiations to re-enter the Erasmus+ programme, and for opposition political parties to pledge their support. Add your name and help us increase the pressure.

europeanmovement.co.uk
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BREAKING: our friends at @ClimateReport_ have been undercover in Project 2025 - the radical plan for a Trump 2nd term. What they’ve found out is remarkable. Learn all about the secretive “second phase” of Project 2025 here 👇

Undercover in Project 2025

Our undercover investigation reveals new details about the highly confidential second phase of Project 2025.

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PostDoc Position Now Open! 🎞 Join our High-Speed AFM team in Leeds Application Deadline: 1st September 2024 Apply Online Here: jobs.leeds.ac.uk/EPSPA1117
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Robin Bon retweeted
nature
@Nature26 Jul 2024
Obituary: V. Craig Jordan (1947-2024) pharmacologist who revolutionized breast cancer treatments go.nature.com/3WiB49g
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Didn't like the way this @JDVance1 bloke (newly picked as #Trump's running mate) slagged off the UK lately. Looked into him. Not great. Made a parody song inspired by @ABBA called "Vance VP" 🎶 Shout out #americast (@BBCsarahsmith/@awzurcher) & @RestIsPolitics for ℹ️ profiles 👍
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A great collaboration between @ScienceLeeds, @ProfValS @JohnInnesCentre using @affimer reagents to target therapeutic agents using virus like particles to breast cancer cells. @AstburyCentre @SophieLiz93 @NC3Rs cell.com/iscience/fulltext/S…

Affimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles

Virology; Molecular biology

cell.com
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It's Twitter so much detail has been skipped; but this'll be the last tweet - see paper & Supp Notes for the full story. Thanks so much to all our collaboration community! and please email / post any feedback; looking forward to it! doi.org/m75j 🧵11/11
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For self-competing E&Z isomers, as long as their binding affinities are nearly equal, the overall bioactivity they apply will be purely determined by the E:Z ratio: Which is the *only* parameter you can reliably control in vivo. Just choose a monochromatic illumination λ! 🧵7/n
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How to escape the concentration-dependency of biological effect? Make a system-internal (intrinsic) compensation method. Self-competitive photoswitches.
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...mean that even in one target tissue, the dose is different in each cell, and changes over time. So your bio-effect will be completely different, even when applying the same wavelength (same PSS & E/Z ratio), *and differs both in space and in time*
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Usually, photopharmacology tries to optimise photoswitching between a high-activity isomer and a low-activity isomer. This is fine for cell culture because all cells see the same drug concentration. But in vivo, no: ADME-PK, variable distance to blood vessels, animals... 🧵3/n
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First up: congratulations to all 20 coauthors - @MarkusM__ & x-less TRP rockstars Michael Schaefer & Konstantin Niemeyer with the heavy lifting; & @RSBon_Lab, @TZ16367, @Intein, & Bruns/Schwarz/Zufall/Muench labs who brought it home! @MolSwitches @photopharma_lit here goes 🧵2/n
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A great opportunity for aspiring researchers to start their academic career in cryo-ET @ScienceLeeds @AstburyCentre not long before the deadline! Please RT! jobs.leeds.ac.uk/vacancy.asp…

Jobs at the University of Leeds

jobs.leeds.ac.uk
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Check out this Fully Funded BHF 3-Year PhD Studentship at University of Leeds linkedin.com/jobs/view/39555…
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