@MarkusM__

PhD Student in organic chemistry | LMU | Thorn-Seshold Group

 München, Bayern
Joined February 2020
  • Tweets27
  • Following438
  • Followers93
Azobenzene molecular switches are repurposed for photoacoustic imaging: picosecond electronic relaxation drives thousand-fold photostabilisation. Now out from @ntziachristos and @ThornSesholdLab #openaccess #AngewandteVIP onlinelibrary.wiley.com/doi/…

Merged Molecular Switches Excel as Optoacoustic Dyes: Azobenzene–Cyanines Are Loud and Photostable...

The organic dyes used in photoacoustic imaging are often photobleachable and hard to quantify as they respond nonlinearly to excitation intensity. However, a systematic method that uses molecular...

onlinelibrary.wiley.com
2
8
1
67
6,024
Just posted the most biologically important photopharmacology story we've had in the last few years. Ditched the photoswitch design principles we used for the last 10 years, & started all over again. And now it will work in vivo. doi.org/10.1101/2024.07.12.6… 🧵1/n🧵
3
14
3
84
10,627
Not a brand new way to do photopharmacology, but it is still under-represented. We argue that it can be very powerful because it translates so well towards in vivo. Take a look! @photopharma_lit @MolSwitches TRPs in tissue :) biorxiv.org/cgi/content/shor…
1
6
22
1,665
Use azobenzene switches for high-performance photoacoustic imaging. Why? let @MarkusM__ 's hot new Angewandte walk through the under-appreciated importance of excited state lifetimes. doi.org/10.1002/anie.2024056… Congrats to all and thanks to @angew_chem !
5
24
1
199
12,432
The 3rd Virtual Munich-Leiden @ChemBioTalks on September 26th, 2023 are exactly 3 weeks away. Register for free to not miss great talks by Brenda Schulman, @TateScience, @DrClintVeale, @KrishnanYamuna, @klanglab, @balskusla, Peng Chen as well as three exciting flash talks.
11
25
4,562
Introducing *infrared*-operated azobenzene photopharmaceuticals, with quantitative Z→E switching, that work in live cells! Preprint out soon with a BANG... Congrats to Dr Ben Baumgartner & our 9-group collaboration for bringing this to life! @MolSwitches @photopharma_lit
4
10
2
92
12,816
Yes, you *can* image azobenzenes & molecular switches, with extraordinary performance! @MarkusM__ +@ntziachristos: doi.org/khfx The future of #MolSwitches? Watch this space! #photoacoustics #optoacoustics @MolSwitches @photopharma_lit @ChemRxiv @biorxivpreprint
6
24
1
138
18,999
As we are entering day 2 of the Artificial Switches and Motors GRC, I want to share with everyone that Doritos contain 3 types of azobenzenes. Not sure if this is a good thing…#GRC_switches_motors, #photoswitches, #tartrazine, #Red40
6
15
97
21,910
Markus Müller retweeted
Simon Duerr@simonduerr26 Mar 2023
Added over 400 new illustrations from @togopic to bioicons (e.g LC-MS) Thank you/ありがとうございます @dbcls AND you can now more easily submit your own illustrations. 1/2
1
6
1
21
2,764
Last talk of the session is for Markus Müller from Dr. Thorn-Seshold group @LMU_Muenchen about photofarmacology of TRPC channels
1
1
2
Biiig congratulations to the group's original PhD student, @philkeil1, for being awarded the 2022 @Evonik PhD prize 🎉 well deserved, and thanks for all the great chemistry 👨‍🔬 Here's to the future! 🍾 @TU_Muenchen @TUMCatalysis
3
3
43
BTDAzo: A Photoswitchable TRPC5 Channel Activator (Thorn-Seshold) @ThornSesholdLab @MarkusMue_MM @LMU_Muenchen #openaccess thanks to #projektDEAL onlinelibrary.wiley.com/doi/…
5
1
30
Congrats Markus on your debut in Angewandte! Photoswitching the TRPC5 cation channel, from cell culture through to low-expression slice explants: cool :D & follow @MarkusMue_MM for many more to come... onlinelibrary.wiley.com/doi/… @angew_chem @MolSwitches @photopharma_lit

BTDAzo: A Photoswitchable TRPC5 Channel Activator **

The TRPs (Transient Receptor Potentials) are important sensory ion channels with roles in perception including of heat, cold, and electrophiles, as well as in signaling and mineralostasis. Here the...

onlinelibrary.wiley.com
5
6
2
42
Markus Müller retweeted
Bach Lab@Bach_Lab6 Jun 2022
Ever wondered how to make optically active chiral alkenes from scratch? Then have a look at Thilo’s work, and how he uses our chiral thioxanthone for olefin deracemization! Out now in @J_A_C_S (ASAP). Awesome work! pubs.acs.org/doi/10.1021/jac… #bach_lab #chemtwitter #newpapermonday

Photochemical Deracemization of Chiral Alkenes via Triplet Energy Transfer

Abstract. A visible-light-mediated, enantioselective approach to axially chiral alkenes is described. Starting from a racemic mixture, a major alkene enant

pubs.acs.org
1
16
1
128
Chem, Biochem, Pharm students: looking for 🎓BSc / Praktika / MSc / PhD🎓 in Munich? @LMU_Muenchen Nachwuchsgruppen present you their research & opportunities: 29th April, 1500, Butenandt-HS (Großhadern) Free 🍺🥨🍻🥨 & science: tinyurl.com/LMUgroups RT & register!
1
19
1
40
Markus Müller retweeted
J. Am. Chem. Soc.@J_A_C_S21 Mar 2022
.@ThornSesholdLab take photopharmacology in vivo: metabolically stable SBT switches photocontrol microtubules in organoids, fish, fly & frog. @high_lithium & @psychescope show GFP-compatibility. pubs.acs.org/doi/10.1021/jac…
7
22
The first photoswitchable activator of the TRPC5 channel is out! doi.org/hd4m (@ChemRxiv) - activity on mouse brain - Full TRPC5-selectivity - photoreversible full-off/full-on photoswitching Congrats to all & to @MarkusMue_MM on the 1st of many great optical tools :D
5
31
Markus Müller retweeted
Hans Renata@hanzyduzit2 Jul 2021
gonna start describing my job as chemieraumdeuter in honor of Thomas Muller
2
14
Markus Müller retweeted
J. Am. Chem. Soc.@J_A_C_S2 Jun 2021
.@ThornSesholdLab and coworkers tune disulfide kinetics and thermodynamics to create redox probes that are selective for the reductant protein, thioredoxin. acspubs.co/Cz2950F0s8F
1
18
5
99
Reversible metathesis of ammonia in an acyclic germylene–Ni0 complex Check out @DrHadlington et al.'s (at @TU_Muenchen & @UofAlabama) NEW Chemical Science article 😍👇 ow.ly/7r3x50DZ3mz
4
3
28
Load more