@PlossLab

Infectious disease biologist, innovator, entrepreneur

 United States
scholar.princeton.edu/plosslab/home
Joined March 2018
  • Tweets560
  • Following1.3K
  • Followers1.4K
69Media
Alexander Ploss retweeted
Iannacone Lab@iannaconelab14 Sep 2024
Great #TWiV episode with @profvrr and @RichCondit interviewing our very own @maini_lab and John Tavis at the International #HBV meeting in Chicago! @PlossLab @ICE_HBV @HepBFoundation @GlobalHep
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Thank you very much @MoAlQuraishi for an outstanding keynote lecture and great discussions at the International #HBV meeting in #Chicago. @HepBFoundation @iannaconelab
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Please check out our newest study led by our very own @KeithBerggren biorxiv.org/content/10.1101/… Many thanks to our brilliant collaborators at @RobSchwartzLab @Crittermechanic @KleinerLabRNA @PrincetonMolBio @NCStateVetMed @Princeton #liver #HBV #epitranscriptome #RNA

Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery

Modification of RNA with N6-methyladenosine (m6A) has gained attention in recent years as a general mechanism of gene regulation. In the liver, m6A, along with its associated machinery, has been...

biorxiv.org
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Just a quick reminder that the abstract submission deadline for the international #HBV meeting hbvmeeting.org/ is June 28 (3pm EDT)! Please register and submit your abstracts! @iannaconelab @HepBFoundation and I are looking forward to welcoming you in #Chicago Please RT
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Alexander Ploss retweeted
Nature Immunology@NatImmunol14 Jun 2024
Loke and colleagues quantify the relative and interactive contributions of genetic and environmental influences on heterogeneity in immune profiles and helminth susceptibility. Read it here: rdcu.be/dKPrZ nature.com/articles/s41590-0…
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Deadline E X T E N D E D! Applications📄 are now⏳ being accepted for the 2024 MolBio Scholars program. For more info and to apply, visit: molbio.princeton.edu/graduat…
MolBio Scholars program announcement. An accessible version of this announcement is available at: https://molbio.princeton.edu/graduate/molbio-scholars

ALT MolBio Scholars program announcement. An accessible version of this announcement is available at: https://molbio.princeton.edu/graduate/molbio-scholars

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🆕Hepatology Snapshot❕ Formation and transcriptional regulation of hepatitis B virus covalently closed circular DNA Full text here👉journal-of-hepatology.eu/art… @plosslab #LiverTwitter
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Babies born to a mother with #hepatitisB have a greater than 90% 📈 chance of developing hepatitis B if they're not properly treated at birth. 👩🏽‍🍼 🔊If your doctor is aware that you have #hep B, they can prevent transmission to your baby. Learn more 💻 hepb.org/treatment-and-manag…
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Adults in the U.S. have very low rates of vaccination, primarily because many were born before the vaccine became a health care standard & mandated for school. 💉The #hepB vaccine is widely used with 1 billion + doses given & is one of the safest & effective vaccines in the 🌍
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Applications📄 are now⏳ being accepted for the 2024 MolBio Scholars program. For more info and to apply, visit: molbio.princeton.edu/graduat…
MolBio Scholars program announcement. An accessible version of this announcement is available at: https://molbio.princeton.edu/graduate/molbio-scholars

ALT MolBio Scholars program announcement. An accessible version of this announcement is available at: https://molbio.princeton.edu/graduate/molbio-scholars

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CRISPR is an amazing gene🧬-editing tool! And the @bsadamson Adamson lab is making it even better!! Read the explainer/press release about their major improvement to prime editing, published in Nature: molbio.princeton.edu/news/20…
Although the specificity of CRISPR-based gene-editing is highly accurate and versatile, the efficiency of installing those edits has been low. In this paper, the Adamson lab describes a more efficient prime editor. Illustration by Caitlin Sedwick

ALT Although the specificity of CRISPR-based gene-editing is highly accurate and versatile, the efficiency of installing those edits has been low. In this paper, the Adamson lab describes a more efficient prime editor. Illustration by Caitlin Sedwick

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Alexander Ploss retweeted
Casanova Lab@casanova_lab18 Apr 2024
It has been an immense privilege and honor to review with John MacMicking and Carl Nathan in @ScienceMagazine the past 40 years of IFN-gamma research, and reflect on its neglected and potential role as a medicine science.org/doi/epdf/10.1126…
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Please check out our newest study deciphering diff. in signaling strength betw type I&III #interferon receptors science.org/doi/10.1126/scis… Outstanding work by @EmilyMesev + fantastic collaboration with the terrific @toettch ! Thanks to everyone involved! @PrincetonMolBio @Princeton

Membrane-proximal motifs encode differences in signaling strength between type I and III interferon...

An intracellular motif in type I interferon receptors ensures they signal more strongly than their type III counterparts.

science.org
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Thank you very much @RMedzhitov for an excellent, thought provoking seminar and insightful discussions during your visit @Princeton EEB and @PrincetonMolBio #immunology @CJEMetcalf @Grahammunology
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Fantastic collaboration with @cambearon on the development of qCARMEN! Outstanding work by lead author @realbriankang aided by Jiayu Zhang, Michael Schwoerer, Amy Nelson and many others. @PrincetonMolBio @Princeton @PrincetonCHW
Cameron Myhrvold@cambearon19 Aug 2023
Really excited to share the first preprint from a project that started in my lab! We hope that others find this approach for scalable, multiplexed, CRISPR-based quantification of gene expression useful. See the thread from first author @realbriankang summarizing qCARMEN:
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World #HepatitisDay23 ! Get vaccinated, get tested, get treated. #eliminate #hepatitis #liver @NO_hep @PrincetonMolBio @EASLEUAffairs @AASLDtweets @HepBFoundation @Princeton
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Alexander Ploss retweeted
ZZ Zhao Zhang@zz_zhaozhang12 Jul 2023
Our new work in ⁦@Nature⁩ to explain how retrotransposons synthesize the 2nd-strand DNA by a circularization process. Story: made some cool findings (we thought) -> actually scooped 40-yr ago by textbook knowledge -> textbook appear to be incorrect. nature.com/articles/s41586-0…

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis

Nature - Retrotransposons hijack the alternative end-joining DNA repair process of the host for a circularization step to synthesize their second-strand DNA.

nature.com
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Our newest study is now online! #Hepatitis delta virus #HDV RNA decline post-inoculation in human NTCP transgenic mice is biphasic | mBio journals.asm.org/doi/10.1128… Congratulations to @stephmaya8 Leeor & Fabian and everyone else involved! @PrincetonMolBio @LoyolaChicago @NO_hep

Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic | mBio

The persistence phase of HDV infection has been studied in some animal models; however, the early kinetics of HDV in vivo is incompletely understood. In this study, we characterize an unexpectedly...

journals.asm.org
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Alexander Ploss retweeted
ElowitzLab@ElowitzLab11 Jul 2023
RNA is informant and agent. Controlled RNA export from cells could enable cell-cell delivery of functional and non-destructive tracking of cell dynamics. Our new paper, led by brilliant @FelixHorns, engineers RNA export for both capabilities: authors.elsevier.com/sd/arti…
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Alexander Ploss retweeted
ScheelLab@ScheelLab5 Jul 2023
Excited to share our labs first @Nature paper! In collaboration with @VintherLab we show that hepatitis C virus #RNA is capped with FAD protecting it from innate immune sensing. rdcu.be/df8p5 Congrats Anna Sherwood and Lizandro Rivera-Rangel 👏🏻🍾 #HCV @UCPH_health
nature
@Nature5 Jul 2023
Nature research paper: Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide go.nature.com/44nyQYy

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide

Nature - Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides...

nature.com
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