Medical writer specializing in autoimmune diseases and JAK inhibitors PhD in Molecular Biology from @Princeton tldr: innate immunity and JAK/STAT signalingš¬
Joined December 2020
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So much type I & III interferon work to share! Take a look at two new papers from my PhD research if interferons or JAK/STAT signaling sound like a good time to you š @PlossLab @toettch @PrincetonMolBio
science.org/doi/10.1126/scisā¦
liebertpub.com/doi/full/10.1ā¦
Emily Mesev retweeted
Why do type I #interferon receptors signal more strongly than type III receptors? The @PlossLab and @toettch lab find that type I receptors harbor a short kinase-binding motif that correlates with greater signaling strength. @PrincetonMolBio #immunology science.org/doi/10.1126/scisā¦
Emily Mesev retweeted
Preclinical experiments decipher how a protein promotes antibody responses through NF-kappaB signaling, scientists uncover the source of signaling strength from interferon receptors, and more in this weekās new issue of #ScienceSignaling. scim.ag/4pW
Emily Mesev retweeted
Incoming viral attackš”ļø! Interferon receptors to the defenseš”ļø, but what exactly is going on inside and outside the cell membrane with Type I & Type III interferon receptors? For some answers, see this explainer of the Mesev, Toettcher, and Ploss paper: molbio.princeton.edu/news/20ā¦
ALT Paper authors (l-r) Alexander Ploss, the Harry C. Wiess Professor of Life Sciences and Molecular Biology; Emily Mesev, first author and graduate student; and Jared Toettcher, Associate Professor of Molecular Biology.
Emily Mesev retweeted
And in an accompanying study, Emily used her synthetic receptors to uncover some interesting differences in JAK requirements for Type I and III interferon receptors!
liebertpub.com/doi/full/10.1ā¦
Emily Mesev retweeted
Please check out our newest study deciphering diff. in signaling strength betw type I&III #interferon receptors science.org/doi/10.1126/scisā¦ Outstanding work by @EmilyMesev + fantastic collaboration with the terrific @toettch ! Thanks to everyone involved! @PrincetonMolBio @Princeton
Emily Mesev retweeted
hello world! new results (with @toettch): tinyurl.com/3595banh
Stem cells can self-organize morphogenesis in vitro w/o spatial patterning cues. But how? We programmed cells to record their signaling histories to map symmetry breaking during gastruloid morphogenesis (1/n)
Some super cool tool development by @PayamFarahani and @toettch!! Very glad I got to be part of this awesome project. Everyone should go read the reviewed paper!
So happy to report that this has now been published in eLife (elifesciences.org/articles/8ā¦), where it might be one of the last stragglers under the "old" model there :)
Thoroughly reviewed & extensively revised since the original preprint - see if you can spot the improvements! :)
Emily Mesev retweeted
While both natural immunity and mRNA vaccines build protection against SARS-CoV-2, the vaccines side-step the development of self-attacking antibodies that frequently occur in COVID-19 patients. @YaleMed @VirusesImmunity #Yale medicine.yale.edu/news-articā¦
Emily Mesev retweeted
Here we are, the in-person part of the #IFNL22 meeting š“š“š“š¤! @CytokineSociety, @Lo_Zanzi, @drdeannasanter, @DrJuanLMendoza, @BoulantLab, @COdendall @Megan_Stanifer, @RamLabUW, @VangelisAndrea1, @baldridge_lab and many more!!
Emily Mesev retweeted
Congratulations ā¦@EmilyMesevā© & thank you for presenting our joint work with ā¦@toettchā© at #cytokines2022 and #ilc4 ā¦#ifnl2022 @CytokineSocietyā© in beautiful #hawaii We are proud of you. Donāt miss ā¦@EmilyMesev ās talk on Sept. 24! ā© @PrincetonMolBioā©
Emily Mesev retweeted
Very excited that my work on the HBV genotypes is published @JHEP_Reports Many thanks to my mentor @PlossLab and everyone in Plosslab. Special thanks to @LeDesma_RA @EmilyMesev for their revisions. Thanks Glenn for the mouse gavage help and our collaborators in this work.
Congratulations to @emperorliu1 on spearheading our newest study characterizing differences in host responses induced by #HBV genotypes. Many thanks to our fantastic collaborators @RobSchwartzLab @Crittermechanic and Lishan Su @PrincetonMolBio @UMmedschool @WeillCornell
Emily Mesev retweeted
Good graphic for how Omicron (and its various BA. family lineages) gets into cells, which differs from prior variants. A nice explainer for its hyper-contagiousness
scientificamerican.com/articā¦ @sciam by @Scudellari and @FalconieriV
Emily Mesev retweeted
Just an FYI - it costs you nothing to reference papers in your field in your own publications. It doesn't lessen the impact or the worth of your work to acknowledge others also did impactful work. Don't be that person. Reference generously.
Did every princeton student really just know that Robert Downey Jr, Matt Damon and Emily Blunt are all chilling on campus making a movie right now? I'm really the only person who didn't know? š seriously?
Emily Mesev retweeted
New study reveals insights into how early immune response defines severity of COVID-19 eurekalert.org/news-releasesā¦
Congratulations to everyone involved, in particular @FDouam and @DevinKenney10! @neidl @PrincetonMolBio @PrincetonInnov
Emily Mesev retweeted
A year ago, a non-academic friend listened to a talk I gave. I thought it went great. My friend disagreed.
She said that academics are experts at making interesting stuff boringāand that we should all take a speech class.
So I did. And here are 6 most useful things I learned.
Emily Mesev retweeted
I refuse to defend my thesis. It's never going to make it in this world if it doesn't learn to fight for itself
Emily Mesev retweeted
Ivermectin: the largest randomized, double-blind trial yet conducted, with early treatment, indicates there is no difference compared with placebo. It doesn't work. Period.
nejm.org/doi/full/10.1056/NEā¦
just published @NEJM
