@KleinerLabRNA

The Kleiner lab investigates the chemical biology of RNA modifications and their role in gene expression regulation. https://xitter.cf/t.co/qic269Hicm

Joined September 2021
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What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity to find out - Biggest surprise was impact of encoded protein function. Fantastic work w/ @LindsayABecker @sofiquinodoz @david_a_knowles biorxiv.org/content/10.1101/…

Genome-wide mapping of mesoscale neuronal RNA organization and condensation

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack...

biorxiv.org
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KleinerLab retweeted
The Muir Lab@MuirLab3 Apr 2025
The final version of our protein transposition manuscript is now published in @ScienceMagazine science.org/doi/10.1126/scie… We’ve added a few new things since our preprint /1

Protein editing using a coordinated transposition reaction

Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding...

science.org
The Muir Lab@MuirLab4 Jun 2024
Ever wanted to swap out an entire internal region of a folded protein for functional biochemical studies? Check out our preprint that has been 5 years in the making, in which we establish a protein editing platform via protein transposition, enabling the insertion of functional cargo or PTMs into internal folded protein regions. #proteinengineering #proteinediting biorxiv.org/content/10.1101/…
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In lab's #FIRSTPREPRINT, we present methods to measure nanometer organization around & between specific proteins in condensates. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
bioRxiv Biophysics@biorxiv_biophys28 Feb 2025
Nanometer condensate organization in live cells derived from partitioning measurements biorxiv.org/content/10.1101/… #biorxiv_biophys

Nanometer condensate organization in live cells derived from partitioning measurements

Biomolecules associate, forming condensates that house essential biochemical processes, including ribosome biogenesis. Unraveling how condensates shape macromolecular assembly and transport requires...

biorxiv.org
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We are looking for a postdoc candidate in RNA chemical biology, broadly defined. Interested applicants can email me at [email protected] with their CV, research summary, and names of 3 references. kleiner.princeton.edu/
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Faculty & students from @EmmanuelCollege, @CSUSBNews and @_hamptonu spent the summer with @PrincetonChem as part of the Visiting Faculty Research Partnership, working on projects that form the core of their research at home but with special focus at Frick: bit.ly/4edp5B8
Faculty and undergrads from Emmanuel College, Cal State San Bernardino and Hampton College

ALT Faculty and undergrads from Emmanuel College, Cal State San Bernardino and Hampton College

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Congratulations to Qais Jaber, awarded a two-year @EMBO Postdoctoral Fellowship supporting excellent postdoc research. Qais will continue his work in the @KleinerLabRNA deciphering RNA modifications in pathogenic bacteria.
Full-color photo of Qais standing on the staircase in Princeton Chemistry's Frick Lab.

ALT Full-color photo of Qais standing on the staircase in Princeton Chemistry's Frick Lab.

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An honor to announce our book has been published! Many thanks to Martin Pettersson, the team at Wiley, and all our amazing contributors for making this exciting project happen! onlinelibrary.wiley.com/doi/…
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We are just opening the summer Visiting Faculty Research Partnership season and are thrilled to be hosting, among others, the Graham Chakafana Lab of @_HamptonU. The lab will be doing malaria research hosted by the @KleinerLabRNA. This marks their 2nd summer @PrincetonChem!
Three individuals (Professor Chakafana in the back) working in the lab at Princeton Chemistry.

ALT Three individuals (Professor Chakafana in the back) working in the lab at Princeton Chemistry.

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