@PlathLab

Twitter feed for the laboratory of Prof. Kathrin Plath @UCLA

 Los Angeles, CA
plathlab.dgsom.ucla.edu/pages/
Joined June 2019
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  • Following167
  • Followers950
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📢 Ready to rethink XIST? Our latest work, now in Cell, challenges two fundamental assumptions about XIST: its cis-limited action, and its role in equalizing gene expression between XX and XY genotypes. Dive in 👇🤿(1/6) sciencedirect.com/science/ar…
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Excited to share our latest work: L126 fine-tunes enzymatic activity of histone H3, a discovery made possible by viewing the nucleosome as an enzyme. We have a gain-of-function mutant – it’s hard to enhance an activity if it doesn’t already exist! sciencedirect.com/science/ar…
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I'm delighted to have been mentioned in the celebratory article commemorating the 30th anniversary of NSMB #Xist_granules #phase_separation @tartaglialab @mitchguttman @PlathLab @NatureSMB nature.com/articles/s41594-0…
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Applying RAP-seq, we found that XIST spreads across the X and, surprisingly, also to autosomal genes. Autosomal targets show female-specific and XIST-dependent H3K27me3 and downregulation of gene expression, indicating that XIST enforces sex differences on autosomes. (3/6)
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This raises the possibility that autosomal genes in other cell types with a dispersed XIST configuration (pre-implantation embryos, germ cells, immune, lung, and cancer cells) may be regulated by XIST. (5/6)
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One of the most extensively studied lncRNAs continues to surprise us! A huge thanks to everyone who helped with this! @Iris_Dror @tsotnech @ClaraCanCanoe @Dr_Sahakyan @YolandaMarkaki @ChronisLab @Mandy_Collier @WeixianDeng @DingFangyuan, #lncRNA, #SexDifferences (6/6)
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In female naïve human pluripotent stem cells (PSCs), XIST is dispersed in the nucleus and X-chromosome dampening (XCD) occurs, raising the question of whether XIST mediates XCD. Knocking out XIST, we found that it is required for XCD in naïve hPSCs. (2/6)
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Check out our latest publication where we developed SEC-seq – a new technology that captures and measures single-cell protein secretion coupled with mRNA transcriptomes published in Nature Nanotechnology! nature.com/articles/s41565-0… 1/2

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

Nature Nanotechnology - Using hydrogel nanovials to capture single mesenchymal stromal cells and their growth factor secretions, the authors link cell secretion to the transcriptome for thousands...

nature.com
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In collaboration with @dinodicarlo, we used hydrogel nanovials to capture and measure the secretion of VEGF-A alongside mRNA transcriptomes. Surprisingly, we found that the VEGFA transcript was not the best predictor of secretion! 2/2
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Congratulations to Plath lab member @JustinLangerman who was awarded the UCLA 2023 Boyer/Parvin Postdoctoral Award. 🎉
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Join us for this incredible @GordonConf on #StemCells and #Cancer in beautiful #Tuscany organized with @CedricBlanpain and @PlathLab!!🔬🧐🇮🇹
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It's time to bring single cell secretion measurement into the multiomics family! Check out our recent BioRxiv submission where we found unexpected relationships between VEGF-A secretion, the VEGFA mRNA, and the cell state: biorxiv.org/cgi/content/shor…
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This work was led by @JustinLangerman and @shreya_udani with the @Dinodicarlo lab
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I’m happy to share our new paper with @LabMomoko published today cell.com/stem-cell-reports/f… which examines how differences in the state of human stem cell pluripotency can lead to favorable or unfavorable outcomes when making brain organoids.

TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to...

Watanabe et al. show that hPSCs maintained under different conditions exhibit variabilities in the expression and function of TGFβ superfamily factors, which tracks with their state of pluripotency...

cell.com
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Congratulations to @YolandaMarkaki and all other award winners for the UCLA 2022 Boyer/Parvin Postdoctoral Award. Tune in for her seminar on "How to silence a chromosome" July 20th at 12PM PT. 🧬
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Plath Lab retweeted
Tracy Tran@TTdevbio
7 Jul 2022
It’s finally out! Many thanks to my colleagues @jacksongcheng and my mentor Andy McMahon at USC for making this happen. #organoid #kidney #screen
USC Stem Cell@USCStemCell
7 Jul 2022
In a @CellStemCell study, scientists from the @USCStemCell lab of Andy McMahon generated kidney-like structures called organoids, and used them to identify potential drugs for adult-onset polycystic kidney disease. @TTdevbio @jacksongcheng @KECKSchool_USC stemcell.keck.usc.edu/mini-k…

USC Stem Cell scientists use mini-kidney models to identify potential drugs for polycystic kidney...

Scientists from Andy McMahon's lab at USC generated kidney organoids, and used them to identify potential drugs for polycystic kidney disease.

stemcell.keck.usc.edu
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Excited to share our recent review on the role of Xist in maintaining X inactivation! sciencedirect.com/science/ar… By @Elsie_youlater and Amy Pandya-Jones
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Happy to share our most recent paper (1/3): FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes cell.com/stem-cell-reports/f…

FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form...

Stem cell biology benefits from in vivo reference maps of human cell types to enable comparisons with human cells generated in vitro using stem cell differentiation. In this study, Chitiashvili and...

cell.com
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We are excited to host @DrPlattLab from @GeorgiaTech as part of our Scientific Excellence Through Diversity Seminar (SEDS) series. Join us Thursday, April 14th at 4pm in Boyer 159 for Dr. Platt’s seminar, which will be followed by a reception in the Boyer Hall Patio.
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