@JonesLabUCSF

We study stem cells- germline stem cells and intestinal stem cells- in different organisms to understand conserved mechanisms that regulate their behavior

 San Francisco
joneslabucsf.com
Joined April 2020
  • Tweets1.1K
  • Following149
  • Followers711
6Media
Thank you @agingdoc1 for sharing! I’m so proud of what we’ve built @UCSFaging and look forward to more advances in geroscience together!
Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM
@agingdoc1
Jan 3
Ageing research hub accelerates translation of basic and clinical science Cross-lab collaborations at this research institute are decoding how people age, and how to fight age-related diseases nature.com/articles/d42473-0…
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Excited to welcome new names to our speaker line up! Our speakers will share cutting edge work on several mechanisms of aging, plus, the promise & challenges of translating them into interventions to improve human health during aging. Keep updated & learn how to join us in Albania, May 2027➡️bit.ly/3SZZGpb #FusionAgingResearch
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Fatty infiltration after muscle injury is a major clinical problem. BARI’s Brian Feeley & colleagues identify distinct human fibroadipogenic progenitor subpopulations and show that DLK1 helps restrain them from turning into fat. New therapeutic angle for muscle injuries!
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Know someone perfect? Share or apply: careers.ucsf.edu/careers/Job…
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We’re hiring! BARI is looking for a highly motivated Chief Strategist who loves aging biology and wants to lead community building across our research network. Help connect faculty, trainees, and ideas that advance the science of aging.
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New ineNeuro, BARI’s Jeanne Paz shows that deleting c-Maf in somatostatin interneurons reduces their synaptic excitation and triggers spontaneous absence-like epileptiform activity. Important refinement of interneuron genetics in epilepsy. eneuro.org/content/13/7/ENEU…
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Check out Dengke Ma in Science Advances: His team built a sensor (GENTIS) that tracks ionic stress in living animals and discovered that proton buildup in the gut drives sleep during molting in C. elegans. A striking link between cellular ion dynamics and behavioral quiescence.
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Thanks so much @NirBarzilaiMD! Very excited to join the academy and looking forward to the upcoming meeting👩‍🔬!
Nir Barzilai
@NirBarzilaiMD
May 26
Congratulations. We are looking forward to having you at our next exciting meeting to continue to push Geroscience forward. @Danbelsky @JonesLabUCSF @wysscoray
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Our conference chairs @JonesLabUCSF @OphirKlein are busy adding the final touches to the first draft of our #stemgastro programme! It's shaping up to be a fantastic meeting, don't delay in joining us in Mexico this November ➡️bit.ly/43wSRNZ
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Congrats to BARI’s Roarke Kamber on being named a 2026 Pew-Stewart Scholar! His work exploring how macrophages team up (or battle) with cancer cells could open powerful new paths for treatments! geroscience.ucsf.edu/news/pi…
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What an inspiring week at #JPM2026! It was energizing to connect with so many innovators pushing the frontiers of healthy aging. From all of us at BARI, thank you, stay safe on your journeys home, and see you soon!
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How do Arctic ground squirrels thrive in extreme hypoxia? BARI member Dengke Ma and his team reveal in @emboreports conserved downregulation of triglycerides boosts resilience to low oxygen & aging, protecting mitochondria & extending lifespan. bit.ly/3NKhiCE
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Congrats to BARI’s Tien Peng on this groundbreaking study in @CellStemCell! Identifying senolytic-sensitive fibroblasts that rewire lung cancer metabolism opens new doors for targeting aggressive tumors. A major step in cancer & aging research. Read more: bit.ly/3L7ATfr
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Research from @ishahjain and colleagues published in @CellCellPress shows that HypoxyStat, can prevent or reverse #mitochondrial disease in a preclinical mouse model. bit.ly/4kh0csc

HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity

A small molecule that increases oxygen-hemoglobin affinity was shown to prevent and reverse pathology in a mouse model of mitochondrial disease, thereby enabling a practical form of hypoxia therapy.

cell.com
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JonesLabUCSF retweeted
nature
@Nature
9 Mar 2025
“It’s a paradigm shift to know that the silent X doesn’t stay asleep,” says Dena Dubal, a neuroscientist and neurologist at the University of California School of Medicine in San Francisco, who led the study. go.nature.com/3Di2d6K
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Have you seen the latest @Nature Index Ratings for Aging research in 2025? BARI’s innovations helped propel @UCSF to #2 globally! Incredibly grateful for our collaborators working with us to push boundaries against age-related decline. Full list here: bit.ly/4aInvZq
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Exciting breakthrough in Parkinson’s research! BARI scientist Ken Nakamura and lab show in @ScienceAdvances how CHCHD2 mutation-induced mitochondrial dysfunction in DA neurons leads to α-synuclein aggregation in vivo. #Parkinsons #Neuroscience bit.ly/4aWt4n4

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology

A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.

science.org
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Congrats to BARI postdoc Jarin Tusnim (Piao Lab), on securing Cure Alzheimer’s Fund award! Jarin investigates how ADGRG1 enables microglia to protect against tau spreading, unlocking new ways to boost microglial resilience and target therapies for AD. Proud of our BARI talent!
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Congrats to our fellow @UCSF aging scientist Lauren Hunt on receiving the 2025 Terrie Fox Wetle Rising Star Award from @AFARorg! Her vital research on palliative care for older adults with dementia is transforming aging health services. BARI celebrates this well-deserved honor!
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Have you had a chance to check out BARI’s Xian Piao and her team’s paper in @NeuronJournal? They show how microglial ADGRG1 activates MYC to drive protective responses against Alzheimer’s – boosting phagocytosis & reducing amyloid. A major step forward in AD research! #Alzheimers
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