Cortical circuits lab @ NYU CNS. Lasers, neurons, coffee.
NYU CNS
Joined October 2019
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Simon Peron retweeted
Pleased our study is now published. We catalog the structures and cell types innervated by corticospinal neurons (CSNs) of forelimb motor cortex. This research lays an anatomical foundation for many future functional studies from the lab.
cell.com/cell-reports/fullte…
Simon Peron retweeted
On my way to visit @UNC_Optics and his awesome department @aps_unc. Looking forward to a great visit. Talk is Tue at 4pm, come say hi if you’re in the area!
And if you’re a grad student or a postdoc (or an eminent professor looking to relive your postdoc years) I’m hiring!
Simon Peron retweeted
The Oldenburg Lab is hiring! If you're interested in using fancy microscopes to stimulate cells and study neural codes let me know.
We're looking for an adventurous postdoc who's interested in optics and neurobiology of movement. oldenburglab.com
Anyone know of studies comparing same side stimulus and motor action (e.g., sound on right of body and rightward movement) vs. stimulus and action on opposite sides?
Simon Peron retweeted
Thrilled to have WenXi's thesis work out in the world! Over the past few years, WenXi has made some cool discoveries about how the brain learns to predict the consequence of an action. 1/9
biorxiv.org/content/10.1101/…
Simon Peron retweeted
Excited about our long-brewing paper exploring dynamics in multi-regional neural circuits in a delayed movement task. Driven by@esthersselva, @yiliu021, and including Jennifer Colonell, Nuo Li and @ShaulDr and others (the MAP collaboration): cell.com/cell/fulltext/S0092… (1/7)
Simon Peron retweeted
Our work using holographic optogenetics to study recurrent activity in visual cortex is out! This work was only possible due to the great collaboration between @AdesnikHillel and @BrentDoiron labs, especially co-firsts @GHandy50 @willyhendricks and myself nature.com/articles/s41593-0…
Simon Peron retweeted
So excited to see the second half of my dissertation work officially out in @CellReports ✨ if you’re interested in Inter-areal communications in sensory cortex check it out 💃🏻 big thanks to everyone who worked on this !!
1/ How do somatotopically-matched regions of sensory cortex interact? In our most recent paper at @CellReports, @__laurenryan__shows that whisker S1-S2 amplify touch bidirectionally via a specialized population of broadly tuned touch cells.
doi.org/10.1016/j.celrep.202…
8/ Thus, a sparse population of multiwhisker cells amplifies touch responses across vS1-vS2 in a whisker-specific manner, showing that topographically matched regions of sensory cortical areas mutually amplify one another’s responses. Congratulations to Lauren and the team!
7/ When she targeted the C2 barrel in vS1, she found that it reduced touch responsiveness in vS2 in a whisker-specific manner.
6/ She then lesioned the 'touch patch’ in vS2, and found that this diminished touch responses in vS1.
5/ She found that despite their rarity, multiwhisker cells carried a large share of touch activity in both directions.
4/ Lauren then used retrograde AAV injections in both areas, targeting just the portion of each area that responded to a specific whisker, and asked how somatotopically-matched regions communicated.
3/ Despite making up only ~1% of neurons, multiwhisker cells nevertheless carried a large fraction of the touch response superficially.
2/ Lauren first imaged L2-4 in both whisker S1 and S2 in mice with two spared whiskers. In both areas, neurons in deeper L2/3 and L4 were mostly responsive to single whiskers, whereas superficial neurons were broadly tuned and responded to multiple whiskers.
1/ How do somatotopically-matched regions of sensory cortex interact? In our most recent paper at @CellReports, @__laurenryan__shows that whisker S1-S2 amplify touch bidirectionally via a specialized population of broadly tuned touch cells.
doi.org/10.1016/j.celrep.202…
Simon Peron retweeted
Does scattering limit your in vivo imaging experiments? We 'super-resolve' neurons using the same trick how PALM/STORM microscopy resolves individual molecules (1/12).
Simon Peron retweeted
🚨#preprint alert 🚨 Happy to share new work from Kevin Ung, in collaboration with Per Nordmark! 🧵 on 👀👋🏻💉1/
Acute loss of fingertip sensation leads to general compensatory changes in eye-hand coordination biorxiv.org/cgi/content/shor… #biorxiv_neursci
Simon Peron retweeted
🚨New paper alert from grad student @avmah44🚨
How do rats compute the value of their environment to guide their choices?
nature.com/articles/s41467-0…
Simon Peron retweeted
I'm very pleased to share our new collaborative study!
We identify the spinal cell type targets of two unique groups of corticospinal neurons, and how these distinct descending circuits interact with the brain.
biorxiv.org/content/10.1101/…
