@willyhendricks

Using fancy lasers and holograms to understand the neural code. Currently a post-doc in the Adesnik Lab at UCBerkeley. 🧠 Also a proud cat dad and step-cat-dad.

 Berkeley, CA
Joined May 2010
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Will Hendricks retweeted
Mora Ogando@MoraOgando19 Jun 2024
Happy Pride month!
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A straightforward logic in which space and feature preference of cortical ensembles in mouse V1 determine their impact on local recurrent activity @willyhendricks @ianOldenburg @GHandy50 @BrentDoiron @AdesnikHillel nature.com/articles/s41593-0…

The logic of recurrent circuits in the primary visual cortex

Nature Neuroscience - Using two-photon (2P) optogenetics and computational modeling, the authors find that neither space-based nor feature-based rules are sufficient to describe cell–cell...

nature.com
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Our work using holographic optogenetics to study recurrent activity in visual cortex is out! This work was only possible due to the great collaboration between @AdesnikHillel and @BrentDoiron labs, especially co-firsts @GHandy50 @willyhendricks and myself nature.com/articles/s41593-0…
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I'm looking for a postdoc to join my new lab. We use fancy optics (Multiphoton Holographic Optogenetics) to understand how neural codes drive movements. I'm really into mentoring, and making the postdoc experience a good one! jobs.rutgers.edu/postings/18… oldenburglab.com
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New Preprint: The Logic of Recurrent Circuits in the Primary Visual Cortex. A fantastic collaboration with co-first authors (@willyhendricks, @GHandy50, me) and a great hand-in-hand experimenter/theorist partnership (Labs: @AdesnikHillel and @BrentDoiron) biorxiv.org/content/10.1101/…

The logic of recurrent circuits in the primary visual cortex

Recurrent cortical activity sculpts visual perception by refining, amplifying, or suppressing incoming visual signals. Despite the importance of recurrent circuits for cortical processing, the basic...

biorxiv.org
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Ah yes, polymers, my speciality!
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Proud to share some of our lab's amazing new work developing and characterizing new opsins for 2-photon optogenetics finally out now in Neuron! Congrats to the first authors and everyone else who helped in this collaborative effort! authors.elsevier.com/c/1eX3a…
My favorite part of writing is rearranging my house.
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Will Hendricks retweeted
Portland Timbers
@TimbersFC28 Oct 2021
Hey @SportsCenter you might wanna give this one a look. #RCTID
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Going to be a great lab!
Ian Antón Oldenburg@ianOldenburg26 Oct 2021
The Oldenburg Lab website is now live! OldenburgLab.com The lab is opening up in May 2022 and will use light to study neural codes. Let me know if you're interested in being a part of it.

Oldenburg Lab

Decoding the motor system through the use of multiphoton holographic optogenetics.

oldenburglab.com
Check out our new preprint! We have a cool new transgenic cre-reporter mouse that expresses soma-targeted GCaMP7s and ChroME- perfect for all optical experiments in vivo! biorxiv.org/content/10.1101/…

Multifunctional Cre-dependent transgenic mice for high-precision all-optical interrogation of...

Causally relating the detailed structure and function of neural circuits to behavior requires the ability to precisely and simultaneously write-in and read-out neural activity. All optical systems...

biorxiv.org
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Plus it makes for pretty movies! (Credit to @ianOldenburg for this one) Here we used holographic optogenetics to rapidly activate ensembles of individual neurons in L2/3 of V1 while imaging GCaMP7s responses.
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Will Hendricks retweeted
Hayley Bounds@HayleyBounds8 Oct 2021
Check out our preprint on a transgenic mouse expressing soma-targeted ChroME and GCaMP7s. Great for all-optical experiments like the 2p stim in this video! Big thanks to the Adesnik lab team and @AllenInstitute biorxiv.org/content/10.1101/…
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Will Hendricks retweeted
SLB
@SLBconference23 Sep 2021
Summer is coming to an end but today in our #SLBOnlineSeries21 we are taking you to sunny California for a peek into the Adesnik lab at UC Berkeley. Check out how the lab is using advanced microscopes to crack the neural codes of perception! youtube.com/watch?v=KVVDUFOE…
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Time to start mining neurons ⛏⛏
Guido Meijer@guido_meijer18 Apr 2021
Excited to share my latest findings! I found that single neurons in the mouse brain encoded the price of cryptocurrencies 🪙 Here is a neuron from the visual cortex which shows a highly significant correlation with the Bitcoin price at the time it was recorded. A thread 👇
Excited to share and have been a part of this collaborative effort to make ultra fast AND potent opsins for 2p optogenetics!! biorxiv.org/content/10.1101/…

High performance microbial opsins for spatially and temporally precise perturbations of large...

Patterned optogenetic activation of defined neuronal populations in the intact brain can reveal fundamental aspects of the neural codes of perception and behavior. The biophysical properties of...

biorxiv.org
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We also provide a wide-range 2p spectra and measured how much depolarization the imaging laser alone causes (ie. crosstalk) for our new (ChroME2f and ChroME2s) opsins and existing variants.
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A very tedious 256-point calibration for our SLM... But at least it has a crazy shape!
Optics arts and crafts day
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