@Peppa_Group

Associate Professor in HIV Immunology/Honorary Consultant in HIV Medicine. Passionate about NK cells and viral infections. Opinions my own

 IIT, UCL
ucl.ac.uk/infection-immunity/people/dr-dimitra-peppa
Joined October 2017
  • Tweets2.5K
  • Following851
  • Followers1.1K
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerOct 10
CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @ImmunityCP cell.com/immunity/fulltext/S… @maxim_artyomov @WashU @nikart89 @NationwideKids @KingsCollegeLon
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Dimitra Peppa retweeted
Rizwan Romee@romeerizwanSep 30
Delighted to share our paper led by Dr Mubin Tarannum in my lab #romeelab @DanaFarber showing how spatially restricted IL-12 in CAR NK cells leads to markedly enhanced tumor responses beating IL-15 and mediated through car and IL-12 signaling synergy through mTORC1
Cancer Discovery@CD_AACRSep 30
Now online: Spatially confined IL-12 programs CAR-NK through mTORC1 to coordinate antitumor immune networks doi.org/10.1158/2159-8290.CD…
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Dimitra Peppa retweeted
Romagnani Lab@RomagnaniLabSep 20
Excited to share our new preprint! We use somatic mutations to show how a central principle of adaptive immunity - clonal selection - shapes innate immune memory to viral infection. A huge thanks to all co-authors and collaborators! biorxiv.org/content/10.64898…
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerSep 12
Replying to @liambrownmn
We've been dabbling with CAR design since 2018, mostly focused on ways to selectively deplete subsets of T cells (in contrast to the wide world of B cell depletion) for autoimmune, immune, and infectious disease. See: scienceblog.cincinnatichildr…
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerSep 2
NK cells leave footprints on the HIV reservoir, leading to a smaller HIV reservoirs in individuals carrying the HLA-C2 allele. HIV escapes NK via mutations Vpu, Gag, Env. nature.com/articles/s41590-0… @NatImmunol @ragoninstitute @seng_toong Intro @HoLabHIV nature.com/articles/s41590-0…
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerAug 6
Replying to @biorxivpreprint
@biorxivpreprint @OnfeltLab The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome biorxiv.org/content/10.64898… @karolinskainst
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerAug 4
Excited this multi-year collaboration is in print @NatureGenet with @mikhailspivakov @MalyValerie @HelenR_J Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as ILC3-specific mediators of genetic risk for #IBD
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerJun 17
Raymond M. Welsh, Jr. (1945–2024)—a life in viral immunology, immune regulation, and scientific mentorship @JVirology @randyb_IUSM @VargaLab @BrehmLab @CloudyMediaBlog doi.org/10.1128/jvi.00663-26
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A landmark @ScienceTM study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. scim.ag/4afX0cL
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerMay 19
HLA-E-restricted T cells primed by a modified HLA-B*57:01 restricted HIV-1 peptide suppress HIV-1 replication @JCI_insight @UniofOxford jci.org/articles/view/203593
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerMay 14
Antibody S22019F Selectively Recognises KIR2DS1 and Enables Analysis of KIR2DS1+ NK Cells and T Cells @QuirinHammer @karolinskainst onlinelibrary.wiley.com/doi/…
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Meidi Gu, @jameslriley et al. show #CARTcell endocytic activity is lost after continuous tumor engagement exasperating fratricide and CART dysfunction. Rab5 expression restores #endocytosis, thereby improving the potency of CARTs. hubs.la/Q04fxHqz0 #TumorImmunology
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Dimitra Peppa retweeted
Nature Immunology@NatImmunolApr 30
May issue is online now, read it here: nature.com/ni/volumes/27/iss…
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New research out of @EmoryUniversity provide a framework in @NatImmunol that features epigenetic programming of myeloid and CD4+ T cells as a major mechanism that promotes decay of the HIV reservoir. 🧫 #OpenAccess 🔓 Give it a read: go.nature.com/4bAkeKy
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerMar 21
Replying to @biorxivpreprint
@biorxivpreprint Transient immune landscape remodelling shapes CD8 T-cell priming during infection biorxiv.org/content/10.64898… @UniofOxford
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Dimitra Peppa retweeted
Waggoner Lab@LabWaggonerJan 29
Replying to @biorxivpreprint
@biorxivpreprint Modeling HIV infection, treatment, rebound, and intervention in human immune organoids @blish_lab @SarahSackey23 @stanfordimmuno biorxiv.org/content/10.64898…
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New research from @iit_ucl & @Peppa_Group has shown that people with both hepatitis B and HIV can maintain strong immune responses to hepatitis B when it is treated with antivirals, challenging long-held assumptions and opening doors for new treatments 🔬ucl.ac.uk/medical-sciences/n…

HBV/HIV co-infection linked to stronger immune responses than HBV alone | Faculty of Medical...

Contrary to long-held assumptions, new UCL-led research shows people with both hepatitis B (HBV) and HIV can maintain strong immune responses to hepatitis B when it is treated with antivirals.

ucl.ac.uk
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Dimitra Peppa retweeted
Gut Journal
@Gut_BMJ16 Dec 2025
#GUTOnline paper by Preechanukul et al entitled "Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection" via bit.ly/4qrDksj @Peppa_Group @iit_ucl @druppygill @AljawharahAlru1 @EddyArbeBarnes @neuro_bo @ICDCRoyalFree #HBV #HIV
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NK cells limit antibody breadth bit.ly/3Yizc1u

NK cells limit antibody breadth

Nature Reviews Immunology - Besides killing infected or transformed cells, interferon-activated natural killer cells can kill T follicular helper cells and may contribute to poor antibody responses...

nature.com
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Thrilled to share our new paper 'Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection' gut.bmj.com/content/early/20… Huge thanks to all collaborators 🙏 @iit_ucl @druppygill @AljawharahAlru1 @EddyArbeBarnes @neuro_bo @Gut_BMJ @ICDCRoyalFree

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection

Background Chronic hepatitis B virus (HBV) infection disproportionately affects people living with HIV, who are often excluded from functional cure studies. Objective This study investigates CD8+ T...

gut.bmj.com
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We found that people with HBV/HIV co-infection on antivirals have more stem-like CD8+ T cells & preserved antiviral responses vs HBV mono-infection, challenging traditional views & opening doors for tailored immunotherapies.
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Building on our previous work: 'HIV/HBV coinfection remodels the immune landscape and natural killer cell ADCC functional responses' pubmed.ncbi.nlm.nih.gov/3868… These studies reshape our understanding of immunity in co-infection & highlight new opportunities for immunotherapy.

HIV/HBV coinfection remodels the immune landscape and natural killer cell ADCC functional responses...

This study provides new insights into the differential signature and functional profile of NK cells in HBV and HIV/HBV coinfection, highlighting pathways that can be manipulated to tailor NK cell-f...

pubmed.ncbi.nlm.nih.gov
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