We use human stem cells to investigate Motor Neuron Disease / ALS @UCL & @TheCrick. Supported by the Medical Research Council & MND Association. #scicomm

London, England
Joined August 2015
Family Fun with the Patani lab @TheCrick !🧬🧑‍🧑‍🧒‍🧒 Come, check out our boardgame and discover your stem cell potential!🔬🧫 #DiscoveryDay
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Our latest @Brain1878: Elevated 4R tau drives neurodegeneration in VCP-related frontotemporal dementia. Link: academic.oup.com/brain/advan… Led by the very talented Dr Christy Hung (currently applying for faculty positions!) @Patanilab @The_MRC @UCLIoN @mndassoc @MNDoddie5 @TheCrick
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Our latest @TrendsNeuro reviews an important mRNA surveillance pathway (NMD) in neuronal physiology and neurodegeneration: sciencedirect.com/science/ar… A pleasure to write this with the talented Marija Petrić Howe @PataniLab @UCLIoN @mndassoc @ListerInstitute @The_MRC @TheCrick
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Our latest @NeuroCellPress reveals widespread mislocalisation of proteins & mRNAs in ALS. This is partly reversed by VCP ATPase inhibition: cell.com/neuron/pdfExtended/… @UCLIoN @mndassoc @The_MRC @ListerInstitute @ojziff @harleyinthehood @erist_yiran @JacobNeeves @PataniLab @TheCrick
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..and it’s a wrap!! Thanks a lot to all the volunteers in the @PataniLab and @LabGandhi + special contribute from @HowePetric 👏🏼🌟
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What cell type are you?? 👀🔬🧫 come play our board game and find out at @TheCrick #DiscoveryDay !
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Our latest review just out in @Brain1878: 'The role of astrocytes in prion-like mechanisms of neurodegeneration'. Great effort by @PhillipSmethurs @neuroblonde @Ben_ClarkeUK and a great collaboration with Dr Katie Sidle. @PataniLab @TheCrick @UCLIoN @mndresearch @mndassoc #ALS
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Check out this TEDx talk by @DoaaMTaha2 from our group entitled 'Astrocytes: The Neglected Stars in ALS'. Here is the link: youtube.com/watch?v=SrXIuEc4… Showcasing some of the work that goes on @PataniLab @TheCrick @UCLIoN @The_MRC @mndresearch #MND #ALS #stemcells
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Our latest paper: 'Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states' just online @genomeresearch: genome.cshlp.org/content/ear… Well done @ojziff @Ben_ClarkeUK @DoaaMTaha2! @PataniLab @TheCrick @UCLIoN @The_MRC @mndresearch
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Our latest collaborative work: 'Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related ALS' just published in @Brain1878: academic.oup.com/brain/advan… @giulia_tyzack @JacobNeeves @PataniLab @RLuisier Lab @UCLIoN @TheCrick @The_MRC
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