@PataniLab

We use human stem cells to investigate Motor Neuron Disease / ALS @UCL & @TheCrick. Supported by the Medical Research Council & MND Association. #scicomm

 London, England
crick.ac.uk/research/labs/rickie-patani
Joined August 2015
  • Tweets2.1K
  • Following1.8K
  • Followers1.8K
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Our latest @Brain1878: Elevated 4R tau drives neurodegeneration in VCP-related frontotemporal dementia. Link: academic.oup.com/brain/advan… Led by the very talented Dr Christy Hung (currently applying for faculty positions!) @Patanilab @The_MRC @UCLIoN @mndassoc @MNDoddie5 @TheCrick
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'Human VCP mutant #ALS/#FTD #microglia display immune and #lysosomal phenotypes independently of GPNMB' Benjamin E. Clarke & Oliver J. Ziff...Rickie Patani @RickiePatani @PataniLab @TheCrick @UCLIoN bit.ly/4i3Md7T
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Explore RNA regulation in neuronal development integrating microscopy, transcriptome and interactome-wide analyses Postdoctoral Research Fellow opportunity in the laboratory of Professor Andres Ramos: Link: ucl.ac.uk/work-at-ucl/search…

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
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Glad to see our review on the use of omics to study glia in ALS led by the superb Stan Majewski (not on X/Twitter) out in @GLIA_Journal! @PataniLab @TheCrick @UCLIoN onlinelibrary.wiley.com/doi/…

Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis

A graphical summary depicting the past and future of ALS glial research, which will require, alongside the application of molecular and cellular techniques, the utilization of more conventional and...

onlinelibrary.wiley.com
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Family Fun with the Patani lab @TheCrick !🧬🧑‍🧑‍🧒‍🧒 Come, check out our boardgame and discover your stem cell potential!🔬🧫 #DiscoveryDay
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Free tomorrow? Why not come to the Crick for family fun at Discovery Day! @PataniLab will be there 11-4 - come and play our stem cell game 🧫🧪🔬
The Francis Crick Institute@TheCrick17 Jul 2024
Join us this Saturday 20 July for Discovery Day! 🧪🙌 We’re opening the Crick up to families for a fun-filled day of activities. Will you become an ‘immune cell Avenger?’ 🦸🏽‍♀️ Or does a science magic show sound like your thing? 🪄 🕒 Explore from 11.00am crick.ac.uk/whats-on/discove…
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Replying to @giulia_tyzack @PataniLab @MNDoddie5
Upadated call details here: ucl.ac.uk/work-at-ucl/search…

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
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Still looking for a talented and enthusiastic bioinformatician to work with us on a super exciting project on DNA damage and RNA metabolism in motor neuron disease. @PataniLab All details here: ucl.ac.uk/work-at-ucl/search… closing on 9th may! @UCLIoN @TheCrick

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
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We are hiring! The @PataniLab is looking for a bioinformatician to work on an exciting project on RNA metabolism and DNA damage in ALS funded by @MNDoddie5, all detalis here: ucl.ac.uk/work-at-ucl/search… still a few days left to apply!

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
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APP antisense oligonucleotides reduce Aβ aggregation and rescue endolysosomal dysfunction in induced pluripotent stem cells derived from people with Alzheimer disease academic.oup.com/brain/advan…

APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in...

APP gene dosage is strongly associated with Alzheimer’s disease pathogenesis. Hung et al. show that antisense oligonucleotides targeting APP can reduce APP

academic.oup.com
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"There is an urgent and unmet need for discovery of disease mechanisms in ALS in order to inform new treatment strategies. Our study is a powerful example of how interdisciplinarity and team science can catalyse such discoveries." - @PataniLab More ⬇️ bit.ly/48qwASn
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Also massive thanks to @ListerInstitute that supports both myself and @RickiePatani and brought us together, playing a massive role in this study!
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Thank you @h_dunning for covering our recent @NatureComms paper on RNA-mediated aggregation in ALS, work led by the amazing @FedericaRaguseo and in collaboration with the great @DiMicheleLAB1, @RickiePatani @FA_Aprile and @YuvalElani imperial.ac.uk/news/250293/u…

Unusual RNA structures could be targets for new ALS treatments | Imperial News | Imperial College...

Studying strange forms of RNA associated with the formation of aggregates in the brains of ALS patients could lead to new avenues for treatments.

imperial.ac.uk
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We're thrilled that collaboration between our #ListerFellows @DiAntonioLAB1 and @PataniLab has contributed to this @NatureComms paper on the role of unusual RNA in #ALS. Congratulations to all involved 🧑‍🔬🎉🧬🎓 nature.com/articles/s41467-0…
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We're so pleased to be able to bring great minds together @DiAntonioLAB1 @RickiePatani
Di Antonio Research Group@DiAntonioLAB118 Dec 2023
Replying to @DiAntonioLAB1
Also massive thanks to @ListerInstitute that supports both myself and @RickiePatani and brought us together, playing a massive role in this study!
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Unravelling what goes wrong in #MND is key to creating a world free of MND. @PataniLab are investigating whether DNA damage plays a role in MND development and progression. @mndassoc is proud to fund research which could pave the way to explore new potential therapies. More ⬇
My Name'5 Doddie Foundation@MNDoddie527 Nov 2023
Last week we announced that we’ve invested £11m into research to find new treatments for MND🔬. This includes a significant investment into a project at @ucl @TheCrick looking at the impact of DNA damage in MND. Click the link to find out more👇: myname5doddie.co.uk/whats-on…

Foundation makes half-million pound investment in new research to unravel the impact of DNA damage...

myname5doddie.co.uk
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It’s Dr Neuroblonde now! 👩‍⚕️Yesterday I successfully defended my PhD! 🎓 Immense gratitude to my incredible examiners @SelinaWray and @krista_rantanen for their insightful questions and making the Viva so enjoyable. Thank you @PataniLab @uclbbk_mrcdtp. Let the next chapter begin!
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Thrilled and incredibly grateful to have recently started a 3 year MND biomedical research project grant from the @mndassoc I was awarded with @RickiePatani to continue investigating the mechanisms of glial dysfunction in MND. 🧪🧠🧑‍🔬@PataniLab @mndresearch
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PataniLab retweeted
PataniLab@PataniLab31 Oct 2023
Our latest @Brain1878: Elevated 4R tau drives neurodegeneration in VCP-related frontotemporal dementia. Link: academic.oup.com/brain/advan… Led by the very talented Dr Christy Hung (currently applying for faculty positions!) @Patanilab @The_MRC @UCLIoN @mndassoc @MNDoddie5 @TheCrick
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Finally, and most importantly, this work is the result of a multi-collaborative effort and it could have not been possible without the amazing @DiMicheleLAB1, @PataniLab, @FA_Aprile and @YuvalElani. Thank you all for your support!
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In this context we demonstrated how formation of intermolecular G4s can trigger aggregation of RNA expansion repeats that are typical of ALS/FTD, further highlighting the biological impact that the formation of these structures can have in regulating cell homeostasis.
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