PataniLab retweeted
'Human VCP mutant #ALS/#FTD #microglia display immune and #lysosomal phenotypes independently of GPNMB'
Benjamin E. Clarke & Oliver J. Ziff...Rickie Patani @RickiePatani @PataniLab @TheCrick @UCLIoN
bit.ly/4i3Md7T
PataniLab retweeted
Glad to see our review on the use of omics to study glia in ALS led by the superb Stan Majewski (not on X/Twitter) out in @GLIA_Journal!
@PataniLab @TheCrick @UCLIoN
onlinelibrary.wiley.com/doi/…
PataniLab retweeted
Free tomorrow? Why not come to the Crick for family fun at Discovery Day!
@PataniLab will be there 11-4 - come and play our stem cell game 🧫🧪🔬
Join us this Saturday 20 July for Discovery Day! 🧪🙌
We’re opening the Crick up to families for a fun-filled day of activities.
Will you become an ‘immune cell Avenger?’ 🦸🏽♀️
Or does a science magic show sound like your thing? 🪄
🕒 Explore from 11.00am
crick.ac.uk/whats-on/discove…
PataniLab retweeted
Upadated call details here: ucl.ac.uk/work-at-ucl/search…
PataniLab retweeted
Still looking for a talented and enthusiastic bioinformatician to work with us on a super exciting project on DNA damage and RNA metabolism in motor neuron disease. @PataniLab All details here: ucl.ac.uk/work-at-ucl/search… closing on 9th may! @UCLIoN @TheCrick
PataniLab retweeted
We are hiring! The @PataniLab is looking for a bioinformatician to work on an exciting project on RNA metabolism and DNA damage in ALS funded by @MNDoddie5, all detalis here: ucl.ac.uk/work-at-ucl/search… still a few days left to apply!
PataniLab retweeted
APP antisense oligonucleotides reduce Aβ aggregation and rescue endolysosomal dysfunction in induced pluripotent stem cells derived from people with Alzheimer disease academic.oup.com/brain/advan…
PataniLab retweeted
"There is an urgent and unmet need for discovery of disease mechanisms in ALS in order to inform new treatment strategies. Our study is a powerful example of how interdisciplinarity and team science can catalyse such discoveries." - @PataniLab
More ⬇️ bit.ly/48qwASn
PataniLab retweeted
Also massive thanks to @ListerInstitute that supports both myself and @RickiePatani and brought us together, playing a massive role in this study!
PataniLab retweeted
Thank you @h_dunning for covering our recent @NatureComms paper on RNA-mediated aggregation in ALS, work led by the amazing @FedericaRaguseo and in collaboration with the great @DiMicheleLAB1, @RickiePatani @FA_Aprile and @YuvalElani imperial.ac.uk/news/250293/u…
PataniLab retweeted
We're thrilled that collaboration between our #ListerFellows @DiAntonioLAB1 and @PataniLab has contributed to this @NatureComms paper on the role of unusual RNA in #ALS. Congratulations to all involved 🧑🔬🎉🧬🎓 nature.com/articles/s41467-0…
PataniLab retweeted
We're so pleased to be able to bring great minds together @DiAntonioLAB1 @RickiePatani
Also massive thanks to @ListerInstitute that supports both myself and @RickiePatani and brought us together, playing a massive role in this study!
PataniLab retweeted
Unravelling what goes wrong in #MND is key to creating a world free of MND.
@PataniLab are investigating whether DNA damage plays a role in MND development and progression.
@mndassoc is proud to fund research which could pave the way to explore new potential therapies.
More ⬇
Last week we announced that we’ve invested £11m into research to find new treatments for MND🔬.
This includes a significant investment into a project at @ucl @TheCrick looking at the impact of DNA damage in MND. Click the link to find out more👇: myname5doddie.co.uk/whats-on…
PataniLab retweeted
It’s Dr Neuroblonde now! 👩⚕️Yesterday I successfully defended my PhD! 🎓 Immense gratitude to my incredible examiners @SelinaWray and @krista_rantanen for their insightful questions and making the Viva so enjoyable. Thank you @PataniLab @uclbbk_mrcdtp. Let the next chapter begin!
PataniLab retweeted
Thrilled and incredibly grateful to have recently started a 3 year MND biomedical research project grant from the @mndassoc I was awarded with @RickiePatani to continue investigating the mechanisms of glial dysfunction in MND. 🧪🧠🧑🔬@PataniLab @mndresearch
PataniLab retweeted
Our latest @Brain1878: Elevated 4R tau drives neurodegeneration in VCP-related frontotemporal dementia. Link: academic.oup.com/brain/advan…
Led by the very talented Dr Christy Hung (currently applying for faculty positions!) @Patanilab @The_MRC @UCLIoN @mndassoc @MNDoddie5 @TheCrick
PataniLab retweeted
Finally, and most importantly, this work is the result of a multi-collaborative effort and it could have not been possible without the amazing @DiMicheleLAB1, @PataniLab, @FA_Aprile and @YuvalElani. Thank you all for your support!
PataniLab retweeted
In this context we demonstrated how formation of intermolecular G4s can trigger aggregation of RNA expansion repeats that are typical of ALS/FTD, further highlighting the biological impact that the formation of these structures can have in regulating cell homeostasis.
PataniLab retweeted
I am very happy to share our latest article now out in @NatureComms. This work led by @FedericaRaguseo demonstrates how the formation of solid aggregates in neurodegenerative diseases can be elicited by RNA aggregation mediated by G-G base pairing 👇👇👇
nature.com/articles/s41467-0…
PataniLab retweeted
Thrilled to share this @NatureComms by @FedericaRaguseo showing that the C9orf72 6nt repeat (GGGGCC)n, relevant for ALS/FTD, forms condensates mediated by G4. Great collaboration @DiAntonioLAB1 @PataniLab @YuvalElani @FA_Aprile
nature.com/articles/s41467-0…