Dad to 3 princesses, Neurologist by day, ALS data scientist by night. Leeds United fan in between.
London, England
Joined March 2014
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Our latest research published in @NeuroCellPress unveils widespread mislocalisation of RNA-binding proteins & mRNA in ALS motor neurons, shedding new light on the complexity of the disease. #ALS #MND
sciencedirect.com/science/ar…
A team of researchers has found that the mechanisms of ALS, a type of motor neurone disease, are more complex than previously thought, with many proteins and mRNA molecules seen in unexpected places in cells.
@ojziff | @harleyinthehood | @PataniLab | #MND crick.ac.uk/news-and-reports…
Oliver Ziff retweeted
Today at Westminster I showed my support for @mndassoc in calling for equal access to Tofersen for all people with SOD1 MND. I was pleased to stop by their Day of Action event in Parliament Square and then raised the issue in Parliament this afternoon. #PrescribeLife
Oliver Ziff retweeted
#MNDAssociation trustee Eleanor Dally, who is receiving Tofersen and living with SOD1 MND, explains why we are here today.
#PrescribeLife #MND
Oliver Ziff retweeted
In #neuromuscular diseases, imaging outcomes enable #neurologists to monitor therapies and assess #nerve and #muscle changes. Read an article on the latest updates in neuromuscular imaging by Drs Ziff (@ojziff) & Morrow at @UCL: ow.ly/azKP50VSLct
@UCLIoN @AANmember @MDAorg
Oliver Ziff retweeted
#Neuromuscular disease assessment using functional & clinical measurement is the topic of our April issue, curated by Medical Editors Dr Sadjadi & Dr Cashman (@DrCCashman) from @Harvardmed.
Our new issue is now live, read it today: ow.ly/alXW50VBRzS
@MDAorg @MGHNeurology
Excited to share our new paper! 🧠 Using iPSC-microglia with VCP mutations, we uncovered immune & lysosomal dysfunction. Secretome transfer revealed JAK-STAT activation in neurons & astrocytes. Great work led by @Ben_ClarkeUK & @PataniLab team! 🚀molecularneurodegeneration.b…
'Human VCP mutant #ALS/#FTD #microglia display immune and #lysosomal phenotypes independently of GPNMB'
Benjamin E. Clarke & Oliver J. Ziff...Rickie Patani @RickiePatani @PataniLab @TheCrick @UCLIoN
bit.ly/4i3Md7T
Oliver Ziff retweeted
'Human VCP mutant #ALS/#FTD #microglia display immune and #lysosomal phenotypes independently of GPNMB'
Benjamin E. Clarke & Oliver J. Ziff...Rickie Patani @RickiePatani @PataniLab @TheCrick @UCLIoN
bit.ly/4i3Md7T
Oliver Ziff retweeted
Why does ALS affect men and women differently? Our research identified 226 sex-linked DNA methylation differences, offering insights into survival, and potential for sex-specific treatments 🧬🥼🔬
Link to the preprint biorxiv.org/content/10.1101/…
Oliver Ziff retweeted
NICE has made the decision to treat tofersen, a specialised genetic therapy for a small subset of people with #ALS #MND developed in the UK, as a general therapy, condemning it to fail their assessment. We must change that decision.
Sign the petition:
ecampaigns.mndassociation.or…
Oliver Ziff retweeted
One of the victims of yesterday's massacre in Jaffa is Ionas Karussis, son of the Greek Prof. Dimitrios Karussis, the senior neurologist at Hadassah Medical Center. Dimitrios is a friend of my mother and one the world's leading authorities on multiple sclerosis. Very sad news.
PSEN1 mutant astrocytes show a neuroinflammatory phenotype with JAK-STAT activation
More than just making amyloid
What if mutations in PSEN1 also predispose inflammation.
We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes.
biorxiv.org/content/10.1101/…
@WrayLabUCL @AlzSocResearch
🧵/6
Oliver Ziff retweeted
I am absolutely delighted to sign for this great club & I will give everything on the pitch.
I can't wait to get started. #MOT
Oliver Ziff retweeted
There's been amazing coverage of our new paper @Nature nature.com/articles/s41586-0… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...
Oliver Ziff retweeted
We are deeply saddened to hear of the death of Rob Burrow CBE.
The impact he had on raising awareness and supporting the fight against #MND will never be forgotten.
Our thoughts are with his friends, family and fans.
Oliver Ziff retweeted
The COMMEND trial shows that Acceptance and Commitment Therapy, a psychological therapy that can be delivered remotely, improves quality of life in people with #ALS #MND
thelancet.com/journals/lance…
In the absence of a disease-modifying treatment, how can doctors best help people with motor neuron disease (MND)?
This week, we published the findings from COMMEND, the largest clinical trial to date of a psychological intervention for patients with MND ▶️ hubs.li/Q02wMdL00
Oliver Ziff retweeted
On my birthday this year @JoeBiden signed a proclamation declaring May 5-12 a week of observance of the Days of Remembrance of the Victims of the Holocaust.
whitehouse.gov/briefing-room…
Thus, in remembrance of the victims & survivors of the Holocaust, a 🧵 about the Iași pogrom: 1/
Oliver Ziff retweeted
I’m delighted to share the cover of a new picture book by me and Kevin Sinfield. Try: A Picture Book About Friendship tells the story of a friendship between two young boys named Rob and Kev💙
Written with Emma Adams and illustrated by Ben Whitehouse @stopmotionben. 50p from the sale of each copy will be split equally between @MNDAssoc and @LDShospcharity
Publishing on 4th July, signed copies are available to pre-order now from @waterstones
waterstones.com/book/try-a-p…
Oliver Ziff retweeted
🔥🚨@TargetALS funded TDP-43 RNA aptamer published🚨🔥
Using deeply phenotyped #ALS post-mortem tissue cohorts we show nuclear TDP-43 pathology is an early event, co-incident with STMN-2 cryptic splicing, preceding cytoplasmic aggreg. & symptom onset 🧵1/6 doi.org/10.1007/s00401-024-0…
Oliver Ziff retweeted
@EMA_News has just approved Tofersen for the treatment of #SOD1 #ALS #MND. Thank you @stephfradette for steering this through. Announcement from @biogen here:
investors.biogen.com/news-re…
@mndassoc @MNDoddie5 @MNDScotland @ENCALS @End_The_Legacy @UKMNDRI @kingsmnd
Oliver Ziff retweeted
Study identifies a fluid biomarker of TDP-43 dysfunction, a central pathological feature of the #ALS-FTD disease spectrum, and demonstrates that such loss of TDP-43 splicing repression occurs presymptomatically @JHUPath, @HopkinsNeuro @Katie_E_Irwin
nature.com/articles/s41591-0…
Oliver Ziff retweeted
TDP-43 loss causes mis-splicing in ALS/FTD. We now show it also induces widespread cryptic 3'UTRs. This increases RNA stability, translation and function of ELK1 and other TFs. Also provides novel targets for biomarker and therapeutics development.
biorxiv.org/content/10.1101/…
