@OfialLab

Developing nucleophilicity and electrophilicity scales at LMU München. We make colours disappear! PI run page. (inactive)

 LMU München
ofial.cup.uni-muenchen.de/
Joined June 2021
  • Tweets66
  • Following113
  • Followers317
6Media
Defining the Synthetic Scope of ortho-Quinone Methides by Quantifying their Electrophilicity (Armin R. Ofial @OfialLab and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/…

Defining the Synthetic Scope of ortho‐Quinone Methides by Quantifying their Electrophilicity

The electrophilicities E of ortho-quinone methides (oQMs) were determined by following the kinetics of oQM reactions with carbanions in DMSO. Embedding the oQMs in Mayr's reactivity scales facilita...

chemistry-europe.onlinelibrary.wiley.com
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It was a real pleasure to give a lecture at the "Organisch-Chemischen Kolloquium" today at LMU Munich University @LMU_Muenchen. Thanks @SaitoGroup for the invitation and wonderful discussions with @OfialLab and all researchers from the chemistry department.
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Reactivities of tertiary phosphines towards allenic, acetylenic, and vinylic Michael acceptors - now published in Chemical Science pubs.rsc.org/en/content/arti…

Reactivities of tertiary phosphines towards allenic, acetylenic, and vinylic Michael acceptors†

The addition of phosphines (PR3) to Michael acceptors is a key step in many Lewis-base catalysed reactions. The kinetics of the reactions of ten phosphines

pubs.rsc.org
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#EurJOC 2-Methylene-1,2-dihydropyridines (2-pyNHOs): Highly Nucleophilic Enamines by @MMHansmann_chem, @Ofial_Lab, and co-workers #OpenAccess onlinelibrary.wiley.com/doi/…

2‐Methylene‐1,2‐dihydropyridines (2‐pyNHOs): Highly Nucleophilic Enamines

2-Methylene-1,2-dihydropyridines (2-pyNHOs) are enamines with strongly polarized exocyclic π-bond. The 2-pyNHOs react with quinone methides to give zwitterionic adducts or the entirely neutral...

chemistry-europe.onlinelibrary.wiley.com
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Happy to see results from the cooperation with the group of Antonio Massa (Univ. Salerno) published in @JOC_OL ! pubs.acs.org/doi/10.1021/acs…

Lactone Enolates of Isochroman-3-ones and 2‑Coumaranones: Quantification of Their Nucleophilicity...

Abstract. Owing to stereoelectronic effects, lactones often deviate in reactivity from their open-chain ester analogues as demonstrated by the CH acidity (

pubs.acs.org
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Ofial_Lab retweeted
EurJOC@EurJOC19 Mar 2024
Reactivity of Electrophilic Trifluoromethylating Reagents by Armin R. Ofial, Herbert MayrH, and co-workers (@OfialLab, @Mayrs_Scale, @LMU_Muenchen) onlinelibrary.wiley.com/doi/…
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Finish of the year: A new class of mesoionic NHOs just accepted @angew_chem. Big thanks to the group as well as the joint work with @OfialLab and @RJ_Mayer. Happy New Year! onlinelibrary.wiley.com/doi/…
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Nucleophilicity of 4-(Alkylthio)-3-imidazoline Derived Enamines (Ofial, Trapp, et al.) @TrappLab, @OfialLab onlinelibrary.wiley.com/doi/…

Nucleophilicity of 4‐(Alkylthio)‐3‐imidazoline Derived Enamines

Enamine activation is a key method to enhance the reactivity of carbonyl compounds in α-alkylation reactions. In spite of their possible role in prebiotic chemistry, enamines derived from aldehydes...

chemistry-europe.onlinelibrary.wiley.com
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Check out our reactivity database! It is a compilation of electrophilicity and nucleophilicity parameters for a wide range of compounds. cup.lmu.de/oc/mayr/reaktions…
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After a full day of physical organic chemistry at #ESOR2023 symposium in Amsterdam, time for diner with @RJ_Mayer, @OfialLab, @ME_Moret and @BreugstLab. #ESOR2023. Great to meet previous colleagues and new one!
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Armin R. Ofial (@OfialLab) of @LMU_Muenchen presents a contributed talk @ESOR2023 on the upper limit of nucleophilicity scales: mesoionic N-heterocyclic olefins. #ESOR2023
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Ofial_Lab retweeted
EurJIC@EurJIC13 Sep 2023
We invite you to join our Virtual Symposium on October 11, moderated by @GrebGroup, in which four experts will present and discuss exciting aspects of modern Lewis-acid Chemistry. Do not miss this opportunity, registration is open! 👇 attendee.gotowebinar.com/reg…
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Our joint work with @OfialLab is just accepted @angew_chem. Big thanks to the team for their great effort! onlinelibrary.wiley.com/doi/…
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Great to see Magenta's @MSCActions "SImCat" work - The effect of S-alkylation on organocatalytic enamine activation through imidazolidine-4-thiones - in cooperation with @TrappLab now published in ChemComm - pubs.rsc.org/en/content/arti…

The effect of S-alkylation on organocatalytic enamine activation through imidazolidine-4-thiones†

Imidazolidine-4-thiones have been suggested as potential prebiotic organocatalysts for light-driven α-alkylations of aldehydes by bromoacetonitrile. Howeve

pubs.rsc.org
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Hammond's Postulate - some new insights on a classic of physical organic chemistry (doi.org/10.1002/ijch.2023000…)
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Happy to see our ICPOC25 Hiroshima conference paper "Reactivity of electrophilic cyclopropanes" with nice contributions by Andreas published! Read on degruyter.com/document/doi/1… @degruyter_pub

Reactivity of electrophilic cyclopropanes

Cyclopropanes that carry an electron-accepting group react as electrophiles in polar, ring-opening reactions. Analogous reactions at cyclopropanes with additional C2 substituents allow one to access...

degruyterbrill.com
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Can Mayr’s reactivity scales be applied to rationalize the mechanism of 3+2 cycloadditions? Absolutely! Check out Le‘s massive kinetic work in @J_A_C_S to which I contributed the computational analysis. @OfialLab doi.org/10.1021/jacs.2c13872
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Check out our recent article live now in @J_A_C_S! Big congratulations to Le Li who obtained the interesting kinetic data and @RJ_Mayer who contributed the computational analysis!! Excellent work! doi.org/10.1021/jacs.2c13872

One-Bond-Nucleophilicity and -Electrophilicity Parameters: An Efficient Ordering System for...

Abstract. Diazoalkanes are ambiphilic 1,3-dipoles that undergo fast Huisgen cycloadditions with both electron-rich and electron-poor dipolarophiles but rea

pubs.acs.org
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Ofial_Lab retweeted
EurJOC@EurJOC20 Mar 2023
📢Together with our Board Member @samilakhdar1, we are proud to present the upcoming talk by Prof. Scott Denmark as part of the Physical Organic Chemistry webinar series! Save the date and join us this Thursday at 4 pm CET 👉bit.ly/3JF1L2S
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Ofial_Lab retweeted
EurJOC@EurJOC14 Feb 2023
Nucleophilicities of Cyclic alpha-Diazo Carbonyl Compounds by Armin R. Ofial and co-workers (@OfialLab @LMU_Muenchen) #OpenAccess onlinelibrary.wiley.com/doi/…
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