Accidental group leader in Cambridge. Inflammation, Immunology, IL-1, Vascular Biology, Cellular Senescence.
Cambridge, England
Joined March 2019
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10 days to go - New fully funded BHF PhD Programme in Cambridge. Please share widely
cam.ac.uk/jobs/phd-studentsh…
New Cambridge BHF-funded 4 year PhD Programme.
Bringing together researchers from Oxford and Cambridge to develop innovative, cross-disciplinary approaches to halt, stabilise and reverse vascular disease.
Please apply here:
postgraduate.study.cam.ac.uk…
Murray Clarke Lab retweeted
CHIP—not just a chip off the ol’ block
Paul R. Carter @PaulCarterology, Murray CH. Clarke @MurrayClarkeLab & team @Cambridge_Uni find common #CHIP mutations produce distinct sex-dependent effects on atherosclerosis and differentially affect macrophage cytokines and clonal expansion, arguing against a common mechanism across CHIP: doi.org/10.1172/jci.insight.…
The images show atherosclerosis in male and female mice transplanted with 10% Tet2+/-.
New Paper Alert! Hard getting this one out... Huge kudos to @PaulCarterology for immense amounts of experimentation - Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis. insight.jci.org/articles/vie…
Of course, huge thanks to @TheBHF for funding. @HLRI_Cambridge @Cambridge_Uni @CambridgeMed and other co-authors @stevesphd @FiggNichola
Very excited to have helped out on this excellent study where IL-1:IL-1R2 controls Tcell contraction.! 👍
Now I'm contracting back to the safety of innate immunity...
Online now: A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction dlvr.it/TL4T79
Murray Clarke Lab retweeted
Looking for an Assistant Teaching Professor and Course Director of the MPhil in Translational Medical Research at Cambridge.
The role is to run academic and research components of the MPhil, and develop teaching and scholarship @MedCambridge @CamBioCampus jobs.cam.ac.uk/job/51441/
Last few days to apply for this. 👍
Job Alert! Come join us in the stunning new HLRI building to study Vascular Inflammation, Macrophages and IL-1 on a 3yr BHF funded grant. @MedCambridge @TheBHF @Cambridge_Uni #Immunology #Macrophage #vascular
Please RT. Research Associate (i.e. PostDoc)
jobs.cam.ac.uk/job/49918/
Murray Clarke Lab retweeted
🚨Job alert🚨
Research Associate (Fixed Term) to join @MurrayClarkeLab in the stunning @HLRI_Cambridge to study vascular inflammation, macrophages and cytokine IL-1.
Funded for up to 3yrs by @TheBHF grant. Apply by 9 February: buff.ly/3PRmHWk
@Cambridge_Uni
ALT Picture of lab equipment on the righthand side and on the lefthand side, text reads: Job Vacancy, Research Associate (Fixed Term), Apply by 9 February
Come and work with us in the stunning new HLRI building to study all things vascular inflammation, macrophage, IL-1.
3yr BHF funded PostDoc postion.
Job Alert! Come join us in the stunning new HLRI building to study Vascular Inflammation, Macrophages and IL-1 on a 3yr BHF funded grant. @MedCambridge @TheBHF @Cambridge_Uni #Immunology #Macrophage #vascular
Please RT. Research Associate (i.e. PostDoc)
jobs.cam.ac.uk/job/49918/
Murray Clarke Lab retweeted
Want to come and help us deliver on our mission to improve cardiovascular and lung health worldwide?
@HLRI_Cambridge are recruiting for multiple new team members at present. Why not take a look? 1/6
Murray Clarke Lab retweeted
Postdoc in single cell RNA-Sequencing and Functional Genomics in Cardiovascular Biology @Cambridge_Uni jobs.cam.ac.uk/job/48385/
Murray Clarke Lab retweeted
Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG 🔗: jobs.cam.ac.uk/job/48333/ (due October 31)!
@CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS
ALT Project description for "Partitioning the effects of high body mass index on risk of future comorbidities".
Murray Clarke Lab retweeted
Fabulous work published in @ScienceMagazine by @AndresFloto @flotocambridge and colleagues 👇
@Cambridge_Uni @RoyalPapworth @MedCambridge
Today in @ScienceMagazine, we report how a bacteria has evolved into a major human pathogen over the last 200 years. Read on, this is going to be an adventurous ride 1/n! science.org/doi/10.1126/scie…
Fantastic new work from my office mate and colleagues.!
Happy to see this work from @JordiLambert and @SebnemOc out today. We identify RUNX1 and TIMP1/CD74/STAT3 as vascular smooth muscle cell regulation through gene regulatory network analysis
nature.com/articles/s44161-0…
@TheBHF @HLRI_Cambridge @Cambridgecardio @MedCambridge
Murray Clarke Lab retweeted
We are pleased to announce our next speaker in the Cambridge Cardiovascular Seminar series - bit.ly/3KaopAl held @HLRI_Cambridge
Please contact Jane if you would like to join remotely bit.ly/4bwhzk4
New Paper Alert! One of the longest, most traumatic projects ever - like working on a moving target at times. We got there. Thanks to all @katpyrillou, @Meri421_cam
@mallat_lab, @MedCambridge, @HLRI_Cambridge and of course @TheBHF 👍👍
insight.jci.org/articles/vie…
Murray Clarke Lab retweeted
Very happy to share our article showing that T follicular helper cells protect from atherosclerosis promoting IgM secretion by MZB cells! It was not an easy path!! I can’t be happier! Thank you#CVR @mallat_lab @cj_binder @LabMcnamara @Jmtarkin and all!
academic.oup.com/cardiovascr…
Little News and Views @GroupXuan and I wrote.
Still disappointed they didn't let us use the pun-tastic:
You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help.
doi.org/10.1038/s44161-023-0…
