🇨🇦 in UK. Assistant Prof studying polygenic scores & multimorbidity @Cambridge_Uni/@PGSCatalog /@ChurchillCol. PhD studying TFs @UofT. Views are my own.
Cambridge, England
Joined April 2011
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Sam Lambert retweeted
🧬 New research led by Dr Carles Foguet, @iamslambert and Prof Mike Inouye, published in Nature Genetics!
OmicsPred brings together genetic prediction models for genes, proteins and metabolites in a single platform.
Read more here: tinyurl.com/23y7uym7
ALT Headshots of Dr Carles Foguet, Dr Sam Lambert and Professor Mike Inouye
Sam Lambert retweeted
Spanning eight years and over 4,800 experiments, a Hughes Lab global collaboration has concluded with the creation of the Codebook: an enormous database that has illuminated how transcription factors influence human gene regulation:
thedonnellycentre.utoronto.c…
Sam Lambert retweeted
A big day for ancestry-specific polygenic risk scores in the PGS Catalog, a phenome-wide atlas of scores for 241 traits (1501 PGS)! Check it out 🔗: pgscatalog.org/publication/P…!
Nature research paper: Population-specific polygenic risk scores for people of Han Chinese ancestry
go.nature.com/474SM5m
Sam Lambert retweeted
New PGS for novel cardiac MRI traits derived using 3D diffusion autoencoders, released this week in the PGS Catalog 🔗: pgscatalog.org/publication/P…
Thanks @SoumickAI for #FAIRdata sharing - find out how to share your polygenic score data @ pgscatalog.org/submit!
7/8
Everything is open. Code, trained model weights, summary statistics and polygenic scores:
🔗 glastonburygroup.github.io/C…
📄 Paper: nature.com/articles/s41467-0…
#MachineLearning #GWAS #PRS #CardiacMRI #UKBiobank #DiffusionModels #ML #AI #ComputerVision
Interested in using multi-omics imputation or TWAS/PWAS approaches? Frustrated by the models being spread across multiple resources? Enter OmicsPred: a centralised resource for genetic prediction of multi-omic traits!
🔗 : omicspred.org
📃 : medrxiv.org/content/10.64898…
Sam Lambert retweeted
🚨 Funded PhD Opportunity (Oct 2026 start)
10 funded 4-year PhD studentships are available through @TheBHF doctoral training programme focused on preventing cardiovascular disease through innovative, data-driven approaches
For more info & how to apply: tinyurl.com/yc7j5s67
ALT Human heart with blood vessels. 3d illustration
Sam Lambert retweeted
It's very hard to prevent vasovagal reactions, such as fainting, as evidenced from this study of nearly 1.4 million blood donors
thelancet.com/journals/lanha…
Sam Lambert retweeted
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/…) & All of Us (pgsc-calc.readthedocs.io/en/… )! But feel free to contact us on Github: github.com/PGScatalog/pgsc_c…!
With that, happy holidays from the PGS Catalog team! 🎁 🎄
Sam Lambert retweeted
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/pgsc_c…
Sam Lambert retweeted
Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/…
Sam Lambert retweeted
New paper in @ESC_Journals
@sritchie73 & colleagues found integrating genetic & metabolic blood tests with existing clinical data could enhance how doctors identify people at high risk of heart disease, leading to earlier prevention strategies
Read more: tinyurl.com/bp5tjck2
ALT Human heart with blood vessels. 3d illustration
Sam Lambert retweeted
Today, we're celebrating a two-decade milestone: on November 5th, 2005, we broke ground at the Donnelly Centre!
Thank you to everyone who has made Donnelly the building it is today!
Sam Lambert retweeted
🚨 Exciting new PhD Opportunity 🚨
Applications are open for 3-year non-clinical PhD studentships with the BHF Cambridge Centre of Research Excellence
📅 Apply by 23 Nov 2025
🌍 Open to UK & international applicants
Find out how to apply here: tinyurl.com/3t59uwbn
ALT The Relationship Between Genetic Factors and Heart Function - Conceptual Illustration
Sam Lambert retweeted
"This study demonstrates that PRS, when incorporated into existing risk prediction frameworks, are unlikely to meaningfully exacerbate disparities in CVD risk stratification."
medrxiv.org/content/10.1101/…
Algorithmic fairness metrics are increasingly used in AI/ML to assess model bias. A clever PhD student (@claireicoffey) suggested applying these methods to clinical risk prediction or polygenic risk scores. See our new preprint for the whole story : medrxiv.org/content/10.1101/…
Algorithmic fairness metrics are increasingly used in AI/ML to assess model bias. A clever PhD student (@claireicoffey) suggested applying these methods to clinical risk prediction or polygenic risk scores. See our new preprint for the whole story : medrxiv.org/content/10.1101/…
Congratulations @claireicoffey on passing your PhD viva (it's not everyday your first PhD student graduates)! It's been a pleasure to supervise your work applying algorithmic fairness techniques to risk prediction models and polygenic scores with Angela Wood & Mike Inouye.
Sam Lambert retweeted
📣 Thrilled to announce our collaborative tutorial with @EBItraining! Dive into the world of polygenic scores and explore the PGS Catalog resources (including pgsc_calc) - ideal for those seeking a comprehensive yet quick overview. Access it online at buff.ly/CEBWMio!
Sam Lambert retweeted
From @sangerinstitute and the CEU!
Translating genetic changes into future health impact
New resource helps bridge the gap between identifying genetic changes linked to health conditions & understanding how these changes impact biological processes
🔗tinyurl.com/3fs4prt3
Sam Lambert retweeted
New PhD studentship opportunities!
The Cambridge BHF CRE will be funding non-clinical 3-year PhD studentships, with a hope to recruit people interested in interdisciplinary projects
👉For more information & how to apply please visit jobs.cam.ac.uk/job/49483/
📅Apply by 16 Jan!
ALT Cartoon of College and university students, researchers and professors studying together, school supplies and digital tablet: education and research concept
📢Fully-funded PhD studying the comorbidities of high adiposity. 🔗: jobs.cam.ac.uk/job/48333/ (2 weeks left, due November 20)
Great work environment @CAMBRIDGE_CEU @HLRI_Cambridge, collab with @AstraZeneca @MikeXiao_JIANG @CambridgeATS.
DM or e-mail for informal enquiries.
Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG 🔗: jobs.cam.ac.uk/job/48333/ (due October 31)!
@CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS
ALT Project description for "Partitioning the effects of high body mass index on risk of future comorbidities".