@GroupXuan

Prof Xuan Li (BHF Senior Research Fellow) research group is based at the Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, UK

 Cambridge, UK
xuanlab.org
Joined September 2019
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  • Following332
  • Followers254
9Media
👀 We are recruiting for a Research Assistant to work on novel therapeutics to mend the broken heart❤️‍🩹with stem cells🧫, RNA 🧬Come join us in fun, collaborative, interdisciplinary environment! 🧑🏻‍🔬👩‍⚕️👩🏻‍🔬 @DrCathyWilson @UnivCamPharm @Cambridgecardio @SCICambridge @HLRI_Cambridge
Dept. of Pharmacology, Univ. Cambridge@UnivCamPharm20 Mar 2024
Curious about the #Heart and #Cardiovascular #Research? 🫀 Dr Lay Ping Ong (@laypingong1) is recruiting for a Research Assistant! Our Research Associate roles in #Therapeutics research are also still open 👏 Click here to apply👉bit.ly/3OX6aR7
Job advert 20/3/24

ALT Job advert 20/3/24

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Only 3 weeks left to submit abstracts for our ECR symposium in Sheffield on 26th April! Head here for details and to submit your abstract: bscr.org/meetings/ecr24
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Little News and Views @GroupXuan and I wrote. Still disappointed they didn't let us use the pun-tastic: You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help. doi.org/10.1038/s44161-023-0…

Expansion of fibroblast-like cells may explain the CANTOS meta-analysis findings for patients with...

Nature Cardiovascular Research - Clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for cardiovascular disease. Neutralization of the cytokine IL-1β (as in the CANTOS...

nature.com
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Our( with @MurrayClarkeLab ) News & Views (rdcu.be/dwftb) for @NatureCVR research article nature.com/articles/s44161-0…
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👉rdcu.be/dwftb
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Pleased to see our study is highlighted as the Editor's pick in JCI This Month. jci.org/articles/view/162129 jci.org/this-month/2023/12 Thanks to @TheBHF
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Karolinska Cardiovascular Research Retreat 2023. Thanks @josejfuster @GroupXuan @lassefolkersen @Hagberglab and all participants. 🫀
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VSMCs are efficient activators of IL-1β that do not use canonical inflammasomes or caspases. Hence, this alternative pathway could be targeted for long-term treatment of CVDs, as it is not central to everyday host defence @MurrayClarkeLab @society_eas 🔗atherosclerosis-journal.com/…
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N&V by @Prosser_Lab on the recent study by @C_M_Loescher, Johanna K. Freundt et al. pinpointing the contributors to #myocardial passive #stiffness. @PennMedicine|nature.com/articles/s44161-0… 👉rdcu.be/dqdpJ
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Xuan Li_Lab retweeted
nature
@Nature2 Nov 2023
Nature research paper: IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer go.nature.com/40oH0PI
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PoV: your main PhD paper is finally published but the Uni's comms office decides that your cell biology and immunology research is best represented by a *big ugly foot* 👣 Still super proud, though. Great team effort @GroupXuan cam.ac.uk/research/news/canc…

Cancer drug could hold hope for treating inflammatory diseases including gout and heart diseases

In a study published on 1 November in the Journal of Clinical Investigation, the researchers have identified a molecule that plays a key role in triggering inflammation in response to materials in...

cam.ac.uk
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This cover image for our research article jci.org/articles/view/162129 shows inflammatory macrophages with many NLRP3 signals (green) around the microtubule-organizing centre (microtubules in red). Taken by Yang Li & @chenxiao027 using Zeiss LSM980 with airyscan 2 @zeiss_micro
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We show targeting microtubules via pharmacological drugs to inhibit PLK1 could provide a treatment strategy for inflammatory diseases characterized by excessive NLRP3 activation. cam.ac.uk/research/news/canc…

Cancer drug could hold hope for treating inflammatory diseases including gout and heart diseases

In a study published on 1 November in the Journal of Clinical Investigation, the researchers have identified a molecule that plays a key role in triggering inflammation in response to materials in...

cam.ac.uk
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Cancer drug could hold hope for treating #inflammatoryDiseases including gout and heart diseases @Cambridge_Uni @jclinicalinvest doi.org/gs2842 medicalxpress.com/news/2023-…
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Check our paper published at JCI, featured as cover for this issue. Brilliant team members (@m_baldri Christain Doreth Yang Li @DrEmilyFW …) and collaborators (@zxh1121 @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat…) for this collective effort. Thanks to @TheBHF .
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#Cover: PLK1 regulates NLRP3 inflammasome activation by controlling microtubule organization: buff.ly/3MmUEgj @GroupXuan @m_baldri @zxh1121 @DrEmilyFW @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat #CellBiology #Immunology
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Xuan Li_Lab retweeted
Michael
@MichaelLee0417 Oct 2023
Labeling bio images just got 10x faster 🏎️ Watch our best AI model yet in action, released today as AI Detect on @BiodockAI. You prompt one object, it finds the rest. Try it for free now!
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CAPture, a centrosome affinity purification method for mammalian cells, is finally out🥳 sciencedirect.com/science/ar… We found that a short peptide of CCDC61/VFL3 can be used to isolate centrosomes / basal bodies cell lysates
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Vesicular transport in a bundle of neurons. Made this movie some years ago. Incredible how much material is constantly being moved around in our cells over long distances by tiny (nanometer scale) motor proteins #microscopy, #science, #cells_are_amazing
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The BSCR is pleased to announce the launch of our ECR mentorship programme! Available to all BSCR members. To discover more, and sign up, head to the members area at bscr.org. Not a member? Join for access to this scheme and more! bscr.org/#memberships.
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