Our lab@UCONN Health; Endothelial, RNA Splicing, Extracellular Matrix and Vascular Inflammation. [email protected]
Farmington, CT
Joined May 2019
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- Following343
- Followers310
- Likes983
MurphyLab retweeted
I am very excited to be part of the study entitled “High prevalence of CNS-directed autoantibodies in patients with schizophrenia” which outlines the identification of many autoantibodies, including those targeting the BBB in schizophrenia patients.
biorxiv.org/content/10.64898…
MurphyLab retweeted
A mouse model of Nose bleeding
#HereditaryHemorrhagicTelangiectasia #HHT
Bmx+ Endothelial Cell ALK1 KO🐭
Recurring epistaxis
Multifocal cerebral microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
Loss of arterial identity (⏬Ephrin B2)
⏬pial or mesenteric arterial tone
Rupture of arteriolar or capillary beds?😁
@mf_navedo @Rong_A_Wang @CircRes 2026
ahajournals.org/doi/10.1161/…
MurphyLab retweeted
Considerations in the Use of Mouse Models of Vascular and Valvular Calcification
Our new article is now published @atvbahajournals
@YinTintut @UCLAHealth ahajournals.org/doi/10.1161/…
MurphyLab retweeted
A postdoc position is open in the @AgalliuLab for a scientist with a strong PhD background in Neuroscience, Neuroimmunology or Vascular Biology and interest in neurovascular / BBdysfunction in CNS disorders. Please contact me with your CV and cover letter if you are interested.
MurphyLab retweeted
am excited to share with everyone a new pre-print of the work of a very talented MSTP student Mary Claire Tuohy entitled “Endothelial Type I Interferon signaling modulates the vascular response to ischemic brain injury”.
biorxiv.org/content/10.1101/…
MurphyLab retweeted
URGENT: A leaked HHS memo proposes cutting all funding to the National #ALS Registry. This would erase decades of critical research & let down 20,000+ who've contributed. We’re calling on Congress to stop this NOW.
Read our letter and take action today: als.org/blog/als-registry-un…
MurphyLab retweeted
In the last 48 hours, congressional Republicans have done so much damage to Americans.
Here are the 5 truly harmful things they passed. 📽️🧵👇🏼
MurphyLab retweeted
We are happy to share that our work on cystic fibrosis and integrin clustering has been published @PNASNews CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation | PNAS pnas.org/doi/10.1073/pnas.24…
MurphyLab retweeted
The latter part of my thesis work on RNA binding proteins and T cells is out in @ScienceMagazine ! Here we find that one of the most conserved elements in the genome helps determine how your immune system responds to pathogens. #ScienceResearch
science.org/doi/10.1126/scie…
MurphyLab retweeted
Postdoc Positions at UCSF on Vascular Regeneration, 2P live imaging, VasPhysiology, Mouse models, Surgery, Single Cell+Spatial Analysis, iDISCO+light sheet, etc. #DevelopmentalBiology #DevNeuro #VascularBiology #VascularPhysiology #bioinformatics #CellBiology. Email me CV & refs.
MurphyLab retweeted
New #Postdoc position available in my lab @LSUHS studying novel regulators of smooth muscle phenotype in #atherosclerosis. Strong training environment @LSUHS_CCDS with intramural Fellowships/Transition Grants and Career Development Workshops. Send CVs to [email protected]
MurphyLab retweeted
Exciting leadership role alert! We're seeking a dynamic scientist in cardiovascular/neurovascular fields to lead our Cellular Biology and Anatomy Dept. Strong support from the Institution and the @LSUHS_CCDS . Check out the details and join our team!
Chair for the Department of Cellular Biology and Anatomy - Shreveport, Louisiana - LSU Health Shreveport - jobs.sciencecareers.org/job/… #sciencejobs
MurphyLab retweeted
Our Review, "Dysregulated Cellular Metabolism in Atherosclerosis: Mediators and Therapeutic Opportunities" in @NatMetabolism is now online! It was a pleasure working with @ChadES22, Felix, @BGCoonLab, Alex, Martin, Klaus, and my dear friend @oren_rom!
rdcu.be/dCvuz
MurphyLab retweeted
Privileged to have contributed to this work; congrats to the whole team! Among many exciting findings, we show evidence of #bloodbrainbarrier changes across sporadic and familial ALS/FTLD
Excited and proud to share our #SingleCell dissection of #ALS and #FTLD out in #Cell this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions.
Although ALS affects #movement vs. FTLD #cognition, the two are nearly identical in the cell types, genes, and pathways they affect, both in #familial (monogenic) and in #sporadic (polygenic) cases, providing hope and candidate targets for common #therapeutic programs, implicating #LongRange-projecting neurons, and #cilia genes and pathways, necessary for their growth, but also #vascular changes and blood-brain-barrier function and integrity.
News: news.mit.edu/2024/als-ftld-s…
Paper: cell.com/cell/abstract/S0092…
Preprint: doi.org/10.1101/2021.07.07.4…
Data: synapse.org/#!Synapse:syn511…
#NeuroDegeneration #ADRD #Alzheimers #FTD #FrontoTemporalDementia #LouGehrigsDisease #MyriamHeiman #SebastianPineda #VeroniqueBelzil #LiveLikeLou @iamalsorg @bsw5020 @alsadvocacy @ProjectALSorg #MotorCortex #BetzCells #VENs #C9orf72 #TDP43 #NeuroDegen #MCx @MTPA_US @NIH @NIHAging @GerstnerFdn @PackardFdn
MurphyLab retweeted
What causes #brainfog in #COVID_19? Our new study @Brain1878 shows that mild SARS-CoV-2 infection suppresses #cerebrovascular Wnt/beta-catenin activity, opening the #blood_brain_barrier. BBB-targeted Wnt ligands mitigate cognitive impairment in mice. A brief tweetorial!
MurphyLab retweeted
Please check out our new methodology paper "A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs" from JoVE jove.com/t/64401
MurphyLab retweeted
#UConnHealth lighting up red to raise awareness during American Heart Health Month. Did you know that heart disease is the leading cause of death in the U.S.? We can protect #OurHearts through small changes to our lifestyles. ❤️
MurphyLab retweeted
An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma biorxiv.org/content/10.1101/…
MurphyLab retweeted
A tenure-track faculty position is available in our Department of Immunology at UConn Health School of Medicine. Vibrant dept, great colleagues, and much more!! Please RT. @uconnhealth @UConnResearch health.uconn.edu/immunology/
MurphyLab retweeted
What is SCN8A? In part, it's a long-standing patient registry. Registration drive extended to Feb1! Each entry helps advance research. 🚀 With less than 1000 cases known - your data is precious. Let's make every #SCN8A story count. 🧬
👉 bit.ly/scn8a-registry #SCN8AAwareness