@lutzlab

Neuroimmunology lab @UICCOM. Unlocking the mystery of the blood-brain barrier. studying #covid_19 and #MSResearch #neuroscience #uic #uiccom

 Chicago, IL
sarahlutzphd.com
Joined January 2018
  • Tweets382
  • Following216
  • Followers320
23Media
What causes #brainfog in #COVID_19? Our new study @Brain1878 shows that mild SARS-CoV-2 infection suppresses #cerebrovascular Wnt/beta-catenin activity, opening the #blood_brain_barrier. BBB-targeted Wnt ligands mitigate cognitive impairment in mice. A brief tweetorial!
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Thanks for the recognition, @vascularbiology ! I’m so proud of our team for this work ❤️
NAVBO@vascularbiology20 May 2024
#NAVBO Member Publication Alert Engineered Wnt7a ligands rescue blood–brain barrier and cognitive deficits in a COVID-19 mouse model Dr. Sarah Lutz lab @Brain1878 2024 @jalees_rehman @lutzlab academic.oup.com/brain/artic…
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Congratulations to Dr. Trevino, my first PhD student, on his degree. Commencement ceremony was a blast!
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Blood borne #cytokines like #IL-10 are often elevated in chronic conditions associated with cognitive impairment (eg. #longCOVID). Protective or pathogenic? Here’s ⁦@sharmasorabh88⁩ unexpected findings in a mouse model of #diabetes. biorxiv.org/content/10.1101/…

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1...

Vascular pathology is associated with cognitive impairment in diseases such as type 1 diabetes, but precisely how capillary flow is affected and the underlying mechanisms remain elusive. Here we show...

biorxiv.org
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Brain endothelial GSDMD activation mediates inflammatory blood-brain barrier breakdown nature.com/articles/s41586-0…. @Nature

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown

Nature - Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.

nature.com
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The beautiful work of @Rishi_CUIMC was published in @NeuroCellPress today. Here we show that glutamatergic neuronal activity drives retinal deep plexus angiogenesis and blood-retina barrier maturation. cell.com/neuron/abstract/S08…
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@EricTopol Eric, I hope you like this study!
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this work complements important recent studies by others establishing a link between BBB permeability and brainfog in patients with COVID-19 and #LongCovid
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@mattcampbelltcd
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And suggests that targeting the BBB could offer hope to improve neurological outcomes of COVID-19 today.uic.edu/covid-brain-fo…
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Sarah Lutz retweeted
Eric Topol
@EricTopol21 Mar 2024
A significantly increased long-term risk of psychiatric disorders and psychotropic meds among people with Covid, and breakthrough infections (vs controls), reduced with vaccination #LongCovid nature.com/articles/s41562-0…
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"Brain fog" is a particularly confounding symptom for people recovering from COVID. Researchers at @uiccom have identified a mechanism that causes this neurological problem in mice. And they found a treatment that helped prevent these changes. today.uic.edu/covid-brain-fo…
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While my lab is obsessed with claudin-5, claudin-25 also has a critical role in regulating white matter integrity in the brain. Another great collaboration with Arnold Munnich @InstitutImagine @tcddublin academic.oup.com/hmg/article…

A loss of function mutation in CLDN25 causing Pelizaeus-Merzbacher-like leukodystrophy

Abstract. Claudin-25 (CLDN-25), also known as Claudin containing domain 1, is an uncharacterized claudin family member. It has less conserved amino acid se

academic.oup.com
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Congratulations to my graduate student, Dr. Cori Fain! Cori’s thesis work on CD8 T cell engagement of MHC Class I molecules on brain vasculature being required for lethal BBB disruption in experimental cerebral malaria made the cover of the February issue of BRAIN @Cori_Fain
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