Joined June 2020
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Excited the bulk of my PhD work is now out in @NeuroCellPress
If you're interested in how motor cortex and striatum work together for behavior take a look at the tweet print or here
tinyurl.com/M1Lesions
#neurotwitter #phdlife #neuroscience @CMU_Bio
1/5 NEW in NEURON! We asked what forelimb M1 contributes to striatal and behavioral dynamics. Short answer: almost everything*. @Markolas11 trained mice to perform a joystick reaching task, w/ and w/out a go cue, then lesioned CFA tinyurl.com/M1Lesions
@cmuneurosci @CmuScience
Interested in how cortex and striatum contribute to trained vs spontaneous behavior??
If you're at #sfn25, check out @pgmid talk Sunday at 1
@SfNtweets #Neuroscience
If you're at SfN, stop by my teeny tiny nano talk Sunday at 1:
"Neural population dynamics during naturalistic versus task-related behavior" w/
@YttriLab
@Markolas11
@adenoeagle
NANO017.01
Mark A Nicholas retweeted
Huh, it's been 8 months since I was on here. Better late than never. I hope this new-ish paper will challenge people to think about the interpretations of our models
STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!)
cell.com/cell-reports/fullte…
@CmuScience @cmuneurosci
I started studying neuroscience back in 2012.
This week I will be defending my PhD from the @YttriLab at @CarnegieMellon
If you are interested in the Zoom option, please reach out.
Mark A Nicholas retweeted
Excited to share my postdoctoral work, with Ilana Witten and @scott_bolkan at @PrincetonNeuro.
TL;DR - we show that two basal ganglia pathways oppositely affect decision-making by very precise control of cortical subpopulations that encode accumulated sensory evidence.
Striatal pathways oppositely shift cortical activity along the decision axis biorxiv.org/content/10.1101/… #biorxiv_neursci
Thank you so much to @BirnbaumJackie1 and @MunibHasnain for presenting their recent paper today at @CMU_Bio @cmuneurosci
Exciting approach to understand how to explain neural data and movement
nature.com/articles/s41593-0…
Mark A Nicholas retweeted
#JNeurosci: @andrewpapale1, @hooks_mac, et al. mapped out connections between neurons in mice that form the cellular basis of coordinated movement planning across the two hemispheres of the frontal cortex. @PittMed
jneurosci.org/lookup/DOI/10.…
Mark A Nicholas retweeted
The first preprint of my postdoc with @jtdudman
is now online! Here we wanted to understand the algorithms mice use when learning to forage in large environments with many potential resources. 1/n biorxiv.org/content/10.1101/…
Mark A Nicholas retweeted
Pls RT!! Do you study the brain and how we can make use of its signals? Come join our exciting faculty at CMU and @cmuneurosci.
As please feel free to reach out with any questions.
jobs.chronicle.com/job/37737…
Mark A Nicholas retweeted
26 years after Larry Swanson emphasized “the amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question:
“What is the [primate] amygdala?”
Check out the preprint 👇
biorxiv.org/content/10.1101/…
Mark A Nicholas retweeted
Neuro + Robotics at @cmuneurosci!
Who wants to come join our amazing community at CMU?
@SCSatCMU @CMUEngineering @CmuScience @CMU_DietrichHSS @CMU_Robotics @CMU_ECE @CMU_Bio @cmualumnihouse @NeuroMechLabX @CMUGroverLab @YttriLab @xaqlab
Please share!
ALT Job ad for tenure-track position in CMU's Neuroscience Institute in the area of NeuroRobotics. Asst or Assoc level. Apply at https://apply.interfolio.com/157182
Hey if you are still around #Sfn24 this afternoon and interested in cell type-specific cortex and striatum concurrent recordings during trial and error learning, come check out our work
@YttriLab @SfNtweets #sfn2024
Mark A Nicholas retweeted
I am glad to share our @BrunoAverbeck @rbartolo_phd recent work published in @NeuroCellPress. We examined the neural mechanisms involved in learning from the gains and losses of symbolic reinforcers in the ventral frontostriatal circuitry. 🧠authors.elsevier.com/a/1jpyf…
Mark A Nicholas retweeted
When you fail to perform at your best right when it matters the most, what's going on in your brain? We can now provide an explanation: Exceptionally high stakes interfere with motor preparation. We can see this in motor cortex. Next up: finding out why.
sciencedirect.com/science/ar…
Mark A Nicholas retweeted
After some lovely updates thanks to reviewer/editor feedback, this work is now published in Neuron!
cell.com/article/S0896627324…
We find monotonic reward signals in M1/PMd, and interactions of reward value with neural reach signals that correlate with an inverted-U in performance
Excited to announce “A neural basis of choking under pressure” is up on biorxiv, where we look at motor cortical population correlates of reward-mediated performance in primates.
biorxiv.org/cgi/content/shor…
Summary in thread below (1/11)
Mark A Nicholas retweeted
Hello all! Please give this a read - and amplify! #SimCo2024 #ThankAMonkey #EndSufferingThruScience
jneurosci.org/content/44/37/…
Mark A Nicholas retweeted
Researchers in @YttriLab discovered how the motor cortex and striatum work together to create movement.
cmu.edu/mcs/news-events/2024…
ALT A cross section rat brain with the primary motor cortex removed.
Mark A Nicholas retweeted
*New preprint* - We (Tim Verstynen, Jonathan Rubin and I) show how cortico-basalganglia-thalamic networks can maximize reward rate 🙂 - biorxiv.org/content/10.1101/…
How cortico-basal ganglia-thalamic subnetworks can shift decision policies to maximize reward rate biorxiv.org/cgi/content/shor… #biorxiv_neursci
Yes there was a time in lab where I did have to care for slime molds...
When you ask your boss @YttriLab to come on your podcast to discuss neurobehavior, and all he wants to talk about are octopuses and slime molds...
Kidding. Mostly.
Eric and I chat about how brains do behaviors and why that's not a simple question.
braininspired.co/podcast/185…
Mark A Nicholas retweeted
1/5 NATURE METHODS TWEETPRINT! Do you have a specific, nuanced, or rare set of behaviors you want to extract from video/pose estimation data? Want to extract those better and with a tenth of the training?
Regardless of species, A-SOiD is here to help
nature.com/articles/s41592-0…
