We develop advanced #opticalmapping and #electricalmapping systems to to pinpoint the exact areas of diseased tissue/cells with abnormal electrical conductivity
United Kingdom
Joined January 2018
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MappingLab retweeted
Beyond reducing arrhythmias, can a therapy restore cardiac electrical conduction? MEA electrical mapping provides the answer by directly measuring conduction velocity, activation patterns, and electrical heterogeneity.
Combining MEA electrical mapping and optical mapping enabled high-resolution analysis of conduction, field potentials, and calcium dynamics in 2D/3D tissues.
A new study shows that inherited arrhythmias like CPVT are not driven by cardiomyocytes (CM) alone.
Using hiPSC-derived neuro-cardiac models, the team found dysfunctional sympathetic neurons can trigger #arrhythmia in otherwise healthy CM.
#electrophysiology #cardiology #mapping
One of the simplest ways to record field potentials and ECG in a Langendorff heart preparation.
Simply apply microelectrode arrays and ECG electrodes directly to the heart.
#CardioTwitter #Electrophysiology #ElectricalMapping #DrugScreening #Cardiotoxicity #iPSC #Heart
It will support precise functional studies in cardiac electrophysiology, enabling detailed investigation of conduction, repolarization, arrhythmia mechanisms, and drug responses.
@jayjay_lu
#Epeeps #electrophysiology #arrhythmias #actionpotential #calcium #Langendorff #Cardiology
We are excited to announce the successful installation of our optical mapping system in the laboratory of Prof. Nipavan Chiamvimonvat at the University of Arizona. The system is now fully operational and provides high-resolution, synchronized mapping of cardiac AP and Ca signals.
MappingLab retweeted
"I have a very strong belief that we need to keep investing in basic research because of just the nature of science, everything builds on everything else. I think you can't always see the value of something at the time that you're investing in it and working on it."
During our interview with 2025 medicine laureate Mary Brunkow in December, she spoke about the importance of basic research. Stay tuned as her official Nobel Prize interview will be available soon.
Brunkow was awarded the 2025 medicine prize for work concerning peripheral immune tolerance.
MappingLab retweeted
Thrilled to share our new preclinical paper: low-dose (nonablative) cardiac radiation reduces VT/VF in NICM — associated with improved ventricular conduction and sympathetic nerve distribution.
Grateful for our stellar team: @alicardsdoc @carmenbergom @drlpedersen @doctorphillep @rentschlerlab and first author Devaki Abhyankar.
🔗 doi.org/10.1016/j.jacep.2025…
#Electrophysiology #VT #CardioOncology #TranslationalScience @uclahealthnews @jaccjournals
The first gene-edited miniature pig model of LQT2 is here.
By combining ECG telemetry, electrical mapping, and optical mapping, this study delivers a truly translational view of hERG-related arrhythmias in a large-animal heart.
Short version:
bit.ly/4jaguCV
In RyR2-R420Q CPVT hearts, subthreshold delayed afterdepolarizations prolonged local repolarization and delayed subsequent activations, increasing ventricular activation dispersion. Optical mapping analyses suggest this mechanism contributes to re-entrant arrhythmia formation.
The optical mapping system was used to record calcium transient. The corresponding isochronal maps generated were further translated into key EP parameters by OMapScope, such asconduction velocity, amplitude, and maximum upstroke velocity.
#electrophysiology #cardiology #heart
Cai et. al. (2025) developed a human engineered heart tissue model to mimic lipotoxic diabetic cardiomyopathy and found that empagliflozin effectively protects cardiomyocytes by reducing mitochondrial damage, endoplasmic reticulum stress, and apoptosis.
#cardiotwitter
Our electrical mapping workflow offers a fast and accessible way to measure epicardial field potentials — ideal for quick assessments in drug testing and disease models. ⚡📷
#activationmap #electrophysiology #Langendorff #drugscreening #cardiotwitter #Cardiology
Unlock the mysteries of cardiac arrhythmias with our advanced Electrical Mapping System! High precision data acquisition and MEA provide unparalleled insights into electrical activity at the tissue level. Perfect for anti-arrhythmic drug screening and toxicity testing.
MappingLab retweeted
Calcium and Contractility Mapping System: An Integrated Solution for Cardiac Research
open.substack.com/pub/jayjay…
#Cardiology #cardiomyocytes #ipsc #mapping #calciumimaging #opticalmapping
The optical mapping system was used to record action potential and calcium transient. The corresponding isochronal maps generated were further translated into key EP parameters by OMapScope, such as conduction time, conduction velocity, APD, CTD.
#arrhythmia #electrophysiology
