PhD candidate with @MalmbergLab in Universitet i Oslo, playing around with some NK cell biology and immunotherapy! 🏳️🌈🏳️⚧️
Joined April 2010
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Daniel Palacios (he/him) retweeted
A cell intrinsic NKG2A/C switch receptor to overcome the critical HLA-E checkpoint. Fun collaboration with the Michel Sadelain lab. Michelle Sætersmoen, Ivan Kotchetkov, @LambertoTR @CoE_PRIMA @UniOslo_MED @Oslounivsykehus @CIM_Sweden
Online Now: Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor dlvr.it/TFV5VC
Finally it's out and I can share with you all the collaborative effort done to produce this paper! Big thanks to @MalmbergLab and all the people who put so much effort into this. journals.aai.org/jimmunol/ar…
Daniel Palacios (he/him) retweeted
Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today cell.com/cell-stem-cell/full…
extensive 15-post-🧵 below
Daniel Palacios (he/him) retweeted
Some of you may have seen an edited version of our video circulating recently, here is the original! Filopodia extension in a migrating fibroblast. #cell #biology #education #animation @rainmaker1973
Daniel Palacios (he/him) retweeted
Made an overview and named ongoing projects in the lab. Maybe we are spreading ourselves too thin? But love them all…
Daniel Palacios (he/him) retweeted
Selective expansion of adaptive NK cells from “superdonors”. This paper describes the pre-clinical evaluation, scale-up and GMP transfer activities paving the way for our next NK cell therapy trial. Team effort led by @AlvaroHaroun and @ebba_sohlberg with lots of collaborators.
New #JITC article: Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia bit.ly/3DP9CaT @ebba_sohlberg @MalmbergLab
Daniel Palacios (he/him) retweeted
Implantable scaffolds rapidly generate and release anti-tumor CAR-T cells in mice go.nature.com/36JwV7U
Daniel Palacios (he/him) retweeted
Very excited to share our approach of interrogating gene functions in human #NKcells with the scientific community! Now online open access 🔓 at @EurJImmunol
tinyurl.com/ys6e8w5j
Daniel Palacios (he/him) retweeted
Two open post-doc positions at the KI node of @MalmbergLab focusing on education in the tumor microenvironment and NK cell persistence in allogeneic recipients (iPSCs). Link to position 1: ki.varbi.com/en/what:job/job… and position 2: ki.varbi.com/what:job/jobID:…
Daniel Palacios (he/him) retweeted
Team @QuirinHammer uncover a potential role for NKG2A-driven "missing self" recognition of #SARSCoV2. A peptide that stabilises HLA-E and yet completely abrogates signalling through NKG2A, unleashing a potent NK cell response to the virus.
I‘m very excited to share our small contribution to the #SARSCoV2 🦠 field. We describe an intriguing way how #NKcells could recognize SARS-CoV-2-infected cells in a peptide-dependent manner. A short thread:
rb.gy/dqmon8
Daniel Palacios (he/him) retweeted
Immune cell working against the flow to send a timely message (wait for it). Happy Valentines! Cells provided from generous blood donor 🙏 and imaging done by @ZambardaChiara
Daniel Palacios (he/him) retweeted
Three open postdoc positions in the Olweus lab. Join our enthusiastic team for an exciting opportunity to develop the next generation T cell based cancer immunotherapy! 2411.webcruiter.no/Main2/Rec…
Daniel Palacios (he/him) retweeted
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy: Cell Stem Cell cell.com/cell-stem-cell/full…
Daniel Palacios (he/him) retweeted
We know so little about Lipid Rafts, and much lesser about their influence on Ion channels. Biophysical characterization, High-resolution live cell imaging and Molecular dynamics simulations hold the key to better understanding their functional intricacies. #FluorescenceFriday
Daniel Palacios (he/him) retweeted
This #FluorescenceFriday let's spend a second to appreciate our #Macrophages who sacrifice themselves in fusing to form #Osteoclasts. No central command, no individual identity, united and dedicated, to keep chewing the #Bones to remove their deformity.
ALT Osteoblast showing actin cytoskeleton (green) and nucleus of fused macrophages (blue)
Daniel Palacios (he/him) retweeted
Did you know that mature platelets lack nucleus?
Beauty of @DanielPal88 's star-like activated platelets!
#FluorescenceFriday @MalmbergLab
Daniel Palacios (he/him) retweeted
Lysosomes of @MalmbergLab are sliding ⛷️on microtubule tracks to get Educated at their school (MTOC), where are you going this weekend now that the schools are closed 😉 Happy #fluorescence Friday!
Daniel Palacios (he/him) retweeted
Wow!
A sperm fuses with an egg to form a zygote. After fertilization, the maternal and paternal chromosomes need to migrate and meet in middle of the zygote.
Our latest work in @NatureComms reveals how this is achieved in mouse zygotes. (1/5)
🔗tinyurl.com/wghs1 @mpi_bpc