The Maday lab investigates the mechanisms, regulation, and functions of autophagy in neuronal homeostasis and neurodegeneration @Penn @PennNGG @CAMBUpenn

Philadelphia, PA
Joined May 2018
Excited to share new work from the lab on microglial lysosome heterogeneity: biorxiv.org/content/10.64898…
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The ALS community has lost one of its most powerful voices. Brooke Eby was diagnosed with ALS in 2022 at just 33 years old. Instead of retreating, she made a choice that changed how the world sees this disease: she shared it all, with honesty and a sense of humor that made it impossible to look away. She brought her employer Salesforce into the fight and raised more than $1 million for research. She helped build ALStogether so people with ALS could find one another. And she shared her story with the Today Show, The New York Times and People. In 2024, the ALS Association was proud to name her an ALS Hero. "Brooke made ALS impossible to ignore, and she made it impossible not to love her while she did it," said ALS Association President and CEO Calaneet Balas. Brooke died Thursday at 37. We will keep going until ALS is livable for everyone, and then cured. Read our full statement: als.org/stories-news/brooke-…
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Maday Lab retweeted
MALIK TILLMAN'S BEAUTIFUL GOAL FOR AMERICA 🦅
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The USA are bound for the next round! 🇺🇸 #FIFAWorldCup

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Replying to @ShorterLab
Very interesting study from @MadayLab on how TRPML1 regulates the cytoskeletal machinery and astrocyte connections to neurons.
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Maday Lab retweeted
"Wonderwall" being sung after an England win never gets old 🏴󠁧󠁢󠁥󠁮󠁧󠁿
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Drew Weissman and Katalin Karikó’s friendship and scientific collaboration began when they met over a Xerox machine. They share the 2023 Nobel Prize in Physiology or Medicine for their discoveries, which paved the way for life-saving mRNA vaccines.
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🧠🤖 Can AI help us find a cure for ALS? @YentliSA explains how researchers are using AI to identify new drug targets by finding patterns hidden in massive biological datasets. 🎙️ Full interview: youtu.be/LtSxpWO5iV4
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ft. Katie Copley, Ashleigh Smirnov, Leland Mayne, @M_Linsenmeier, @JackRubien, @YSPTSPS, Bo Lim Lee, Hana Odeh, Longsheng Lai, @yiweichang Ben Black & @ShorterLab (@BB_UPenn) @ScienceMagazine science.org/doi/10.1126/scie…
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Check out this Q&A by @ALSTDI highlighting Dr. Katie Copley, a Corsalex Postdoc Fellow in our lab @YaleNeuro! The Coralex Postdoctoral Fellowship program is open for application: corsalex.com/corsalex-fellow…
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#ICYMI: @PennMedicine & @ChildrensPhila have named renowned physician-scientist Eric Morrow as the founding director of the Lurie Autism Institute ft. Jon Epstein, @MadelineSBell, Dan Rader, Jeffrey Lurie & Eric Morrow tinyurl.com/55nc2ws6
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Maday Lab retweeted
Transcytosis-mediated anterograde transport of the receptor TrkA mediates the formation of presynaptic sites in sympathetic neurons | Science Signaling science.org/doi/10.1126/scis…
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Maday Lab retweeted
Specialized RNA molecules could counter ALS neurodegeneration: pennmedicine.org/news/specia…
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Maday Lab retweeted
May we all keep fighting. Good night moon.
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Dr. Leonard Petrucelli, founding director of our Neuroscience Institute, has been awarded the Sheila Essey Award for ALS Research, recognizing work that has helped reshape how the disease is understood and studied. 🧠 His research continues to move the field forward, with a focus on earlier diagnosis, better ways to track progression and improving care for patients today. Learn more about his ALS research: loom.ly/FKm37qU
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Out in Nature today: how next-gen GLP-1 drugs cut cravings, not just hunger. Congrats to co-first authors Lizzie, Bugra, and Isabelle in @GulerLab lab traced the circuit — drug → central amygdala → less dopamine in reward circuits. Mostly Ali's lab; we got to contribute. Proud of this team. rdcu.be/fhfOm #neuroscience #UVA
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