@LabibDavidA

MD-PhD Student @DukeMSTP | @NYSCF @HanLabCornell alum | @Cornell ‘20

 Durham, NC
Joined April 2020
  • Tweets61
  • Following203
  • Followers178
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Happy to share that our paper on new markers of a neurotoxic, reactive astrocyte sub-state is out! Huge thanks to @JunminPengLab, @Calabre04804429, @LiddelowSA, and most of all @fossati_v and @nyscf who made this possible. A 🧵. frontiersin.org/articles/10.…
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David Labib retweeted
Steven Sloan@Sloan_Lab8 Jan 2025
Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental glial biology to stem cells and tumor biology. rdcu.be/d5ADz A 🧵(also come to 🦋!)
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Proud to see our image selected for the November @CellStemCell cover, spotlighting two papers from my lab and @Pluchinolab that showcase the power of patient stem cell-derived models to study multiple sclerosis. (1/2)
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I am excited to present my latest research at the @ISSCR Athens International Symposium, taking place in Athens, Greece on 3-4 April 2025. Register to hear my presentation! invt.io/1txbiu3cxbd

I'm speaking at Athens International Symposium, join me!

Register now

invt.io
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No longer active on social media, but I had to come back to share the joy for this study. A long journey and a bold goal when I decided a decade ago to use stem cell models to study MS, despite the many challenges. Thanks @TesarLab @bllclayton @liliannebarbar and all co-authors!
New York Stem Cell Foundation Research Institute@nyscf26 Aug 2024
Our new study led by @fossati_v & @TesarLab is out in @CellStemCell! We report the largest collection of patient stem cell models of multiple sclerosis & use them to show that glial cells contribute to the disease, pointing to the need for new therapies: nyscf.org/resources/human-st…
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Priya Prakash@pryprk30 Nov 2023
Happy to share our paper “Proteomic profiling of Interferon-Responsive Reactive Astrocytes in rodent and human” out now in @GLIA_Journal! 🧠✨@NYULH_Neuro @NYULH_postdocs Thread👇🏽 (1/7) onlinelibrary.wiley.com/doi/…

Proteomic profiling of interferon‐responsive reactive astrocytes in rodent and human

Characterizing the molecular underpinnings of interferon-responsive reactive astrocytes: What is their proteomic signature? Does their proteome correlate with their transcriptome? How are they...

onlinelibrary.wiley.com
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A large longitudinal (298,000 cells and nuclei) transcriptomic investigation of glial differentiation in mouse embryos and hiPSCs used to optimize a mouse astrocyte differentiation protocol New from @LiddelowSA and colleagues nature.com/articles/s41593-0…
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“When I grow up, I want to be a __”. Most of us had to answer this question at some point; however, we don’t understand how the nervous system answers it. We investigated how CNS cells decide what identity (‘job’) they should acquire when they mature (‘grow up’). (thread: 1/12)
Nature Neuroscience
@NatureNeuro11 Sep 2023
A large longitudinal (298,000 cells and nuclei) transcriptomic investigation of glial differentiation in mouse embryos and hiPSCs used to optimize a mouse astrocyte differentiation protocol New from @LiddelowSA and colleagues nature.com/articles/s41593-0…
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Want to convert your favorite Drosophila Gal4 lines into LexA or Flp? Check out our latest toolkit for this purpose! academic.oup.com/g3journal/a…
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today, after i narrowly missed my subway, a woman came up to me and ask if i spoke spanish. i said yes and she asked me how to get to east harlem. i told her that we would be transferring at the same stop, so she should just stick with me. we sat down and started talking
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Meet the 2022 Class of NYSCF - Druckenmiller Fellows: @spencerhaws (@Penn), @NoopurKhobrekar (@MSKCancerCenter), @Morgani_S (@nyugrossman), Munisha Mumingjiang (@Cornell), & @chandrrrika (NYSCF) nyscf.org/programs/extramura…
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Great turnout so far at the #ISSCR2022 poster session! Come visit more posters TODAY on high-content phenotypic #screening for drug discovery (by @dan_paull) and the role of #microglia-related genetic risk variants in #Alzheimers (by @chandrrrika) from 3-4pm!
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David Labib retweeted
Meyer Lab@MeyerLab16 Jun 2022
Happy to share the latest publication from the lab, focused on the role of astrocytes in neurodegeneration relevant to glaucoma. Led by fantastic co-first authors @kirstin_8 and @catiasvgomes! cell.com/stem-cell-reports/f…

Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem...

Gomes and colleagues show that astrocytes carrying the glaucoma-associated OPTN(E50K) mutation exhibit a diseased phenotype including autophagy disfunction and lack of neurosupportive functions....

cell.com
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Stop by our poster if you would like ti know more about our studies on reactive astrocytes and neurodegenerative diseases #ISSCR2022. Poster #363 @LabibDavidA
New York Stem Cell Foundation Research Institute@nyscf15 Jun 2022
Happening today at #ISSCR2022! Come visit @LabibDavidA at poster #363 from 6:30-7:30pm to hear about NYSCF’s research on novel markers of human reactive #astrocytes!
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Happening today at #ISSCR2022! Come visit @LabibDavidA at poster #363 from 6:30-7:30pm to hear about NYSCF’s research on novel markers of human reactive #astrocytes!
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David Labib retweeted
Steven Sloan@Sloan_Lab1 Jun 2022
It brings me great pride to share this new preprint from our lab! This was a true team effort spearheaded by the superstar undergraduate (soon to be PhD student @PennNGG) @avoss2022 who pivoted to this project when pandemic rules kept undergrads at home biorxiv.org/content/10.1101/…

Computational Identification of Ligand-Receptor Pairs that Drive Human Astrocyte Development

Extrinsic signaling between diverse cell types is crucial to nervous system development. Ligand binding is a key driver of developmental processes, but it remains a significant challenge to disenta...

biorxiv.org
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New Research: Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models: Astrocytes respond to injury, infection, and inflammation in the central nervous system by… frontiersin.org/articles/10.… #Molecular #Neuroscience
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Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17. nature.com/articles/s41586-0…

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

Nature - Fgf17 in young CSF boosts oligodendrocyte progenitor cell proliferation and differentiation in the aged hippocampus, improving memory function.

nature.com
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Excited to share our paper in @FrontImmunol describing a new role for NLRP3 inflammasome modulation in postoperative neurocognitive disorders. The start of a great collaboration with @Duke_Shinohara @Duke_Anesthesia @DukeMedSchool frontiersin.org/article/10.3…
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Our first study in collaboration with ⁦@Calabre04804429⁩ at ⁦@JohnsHopkins⁩ is out! Cheers to many more projects together! Huge thanks to Matthew Smith for leading the work and Hector Martinez for making toms of iPSC-astrocytes! 🤩🎉 doi.org/10.3389/fnmol.2022.8…

Frontiers | Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligod...

Astrocytes are instrumental in maintaining CNS homeostasis and responding to injury. A major limitation of studying neurodegenerative diseases like multiple ...

frontiersin.org
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We’re thrilled to announce two new @FrontNeurosci studies from NYSCF’s @fossati_v in collaboration with Peter Calabresi @HopkinsMedicine deciphering the molecular properties of human reactive #astrocytes & understanding their impact on myelination: nyscf.org/resources/when-goo…

When Good Brain Cells Go Bad: New Findings from NYSCF and Johns Hopkins Precision Medicine Initia...

The Context: Astrocytes are support cells in the brain that help our neurons function properly. However, these typically helpful...

nyscf.org
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