@LabRubinstein

We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.

 Israel
moranrub.wixsite.com/rubinsteinlab
Joined October 2018
  • Tweets375
  • Following475
  • Followers388
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RubinsteinLab retweeted
HaitinLab@HaitinLab30 Nov 2025
๐ŸšจIt's finally out!๐Ÿฅ‚ | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
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RubinsteinLab retweeted
HaitinLab@HaitinLab7 Jul 2025
Excited to share our new paper in @FEBSJournal! ๐ŸŽ‰ We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation ๐Ÿ”— doi.org/10.1111/febs.70181 @peterslab1 @TAUMedFaculty
HaitinLab@HaitinLab26 Dec 2024
๐ŸšจNew preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
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RubinsteinLab retweeted
Igor Ulitsky@IgorUlitsky29 May 2025
Stop the doom scrolling! A new ๐Ÿ—ž๏ธ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A ๐Ÿงตbiorxiv.org/content/early/20โ€ฆ
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๐Ÿ’–Love, Science & the Brain๐Ÿ’– This #ValentinesDay, meet Profs. Moran Rubinstein & Yoni Haitin - a couple bonded by love & a passion for #neuroscience. From BSc to leading labs, their journey is proof that great discoveries are made together. ๐Ÿ”ฌ Read more: linkedin.com/feed/update/urnโ€ฆ
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RubinsteinLab retweeted
Alomone labs
@Alomone_Labs26 Mar 2024
The New Dravet syndrome mouse model sheds light on the disease! This research by Prof. Rubinstein & collaborators uses a more accurate mutation to study Dravet & its causes: frontiersin.org/articles/10.โ€ฆ #epilepsyAwarenessDay #DravetSyndrome @FrontiersIn #EpilepsyAwareness

Frontiers | Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense...

Dravet syndrome (Dravet) is a severe congenital developmental genetic epilepsy caused by de novo mutations in the SCN1A gene. Nonsense mutations are found in...

frontiersin.org
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RubinsteinLab retweeted
HaitinLab@HaitinLab7 Mar 2024
Have you ever thought that chloride intracellular channel (CLIC) proteins function as fusogens? ๐Ÿซง From ๐Ÿงช&๐Ÿ’Ž to ๐Ÿชฑ we're happy to share our recent paper showing just that! nature.com/articles/s41467-0โ€ฆ
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I am sad to report that Bill Catterall has died. He was an enormous presence @UW.
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RubinsteinLab retweeted
HaitinLab@HaitinLab14 Feb 2024
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RubinsteinLab retweeted
HaitinLab@HaitinLab14 Feb 2024
It's a wrap! Until next time!! #BPS2024
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Three days full of sodium channel talks. Cant wait for it to start! See many of you in Grindelwald!
Hugues Abriel @[email protected]@SwissIonChannel19 Jan 2024
Very soon, we will start the first and unique Worldwide Sodium Channel Conference in the Alps #Grindelwald #Switzerland. The final program is out sodiumchannelseminars.org/Soโ€ฆ Want to know how much snow we have? Here is the webcam: jungfrau.ch/fr-ch/live/webcaโ€ฆ #IonChannels #SodiumChannels
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Dravet syndrome is a devastating form of epilepsy that can strike before an infantโ€™s first birthday. Researchers at the Allen Institute and @SeattleChildren are developing a precise gene replacement therapy that has shown promising results in mouse models. biorxiv.org/content/10.1101/โ€ฆ

AAV-mediated interneuron-specific gene replacement for Dravet syndrome

Dravet syndrome (DS) is a devastating developmental epileptic encephalopathy marked by treatment-resistant seizures, developmental delay, intellectual disability, motor deficits, and a 10-20% rate of...

biorxiv.org
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RubinsteinLab retweeted
iriareyes@iriareyes6 Sep 2023
About our latest results!! #Dravet #Genetherapy may be the first step toward curing a rare genetic epilepsy. | The Scientist Magazineยฎ the-scientist.com/news/defenโ€ฆ @LabRubinstein @IGMM_Montpel @FundacionDravet @curedravet
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RubinsteinLab retweeted
Raj Karda@Dr_RKarda24 Jul 2023
Research Fellow post available to join my team, pre-clinical gene therapy project ๐Ÿงฌ๐Ÿง  applyhttps://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?nPostingId=5896&nPostingTargetId=12733&id=Q1KFK026203F3VBQBLO8M8M07&LG=UK&languageSelect=UK&mask=ext @UCL_IfWH @_BSGCT @UCLTRO
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RubinsteinLab retweeted
Adel@adelssane23 Jun 2023
๐ŸŒŽ Today is Dravet Syndrome Awareness Day! All patient organizations all around the world stand united for this special day! We are stronger together โœŠ WE NEED A CURE ๐Ÿ™๐Ÿ’œ@curedravet @FundacionDravet @DravetUK @alliancedravet @RetoDravet @DSFeu @DravetSyndromeJ @dravetlatam
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ื˜ื™ืคื•ืœ ื’ื ื˜ื™ ื—ื“ืฉื ื™ ืขืฉื•ื™ ืœืกื™ื™ืข ืœืชืกืžื•ื ืช ืืคื™ืœืคืกื™ื” ื”ืชืคืชื—ื•ืชื™ืช ืงื˜ืœื ื™ืช ืฉืคื•ื’ืขืช ื‘ื™ืœื“ื™ื. ื”ืžื—ืงืจ ื ืขืจืš ื‘ื”ื•ื‘ืœืช ื“โ€ืจ ืžื•ืจืŸ ืจื•ื‘ื™ื ืฉื˜ื™ื™ืŸ @LabRubinstein ื•ื”ืกื˜ื•ื“ื ื˜ื™ืช ืกื’ืณื ืคื“ื™ืœื” @saja_fadila95, ืžื‘ื™ื”"ืก ืœืจืคื•ืื” ื•ืžื‘ื™ื”"ืก ืกื’ื•ืœ ืœืžื“ืขื™ ื”ืžื•ื—, ื•ื“โ€ืจ ืืจื™ืง ืงืจืžืจ, ืžืื•ื ' ืžื•ื ืคืœื™ื™ื” ื‘ืฆืจืคืช. hayadan.org.il/%d7%98%d7%99%โ€ฆ

ื˜ื™ืคื•ืœ ื’ื ื˜ื™ ื—ื“ืฉื ื™ ืขืฉื•ื™ ืœืกื™ื™ืข ืœืชืกืžื•ื ืช ืืคื™ืœืคืกื™ื” ื”ืชืคืชื—ื•ืชื™ืช ืงืฉื” ื•ืงื˜ืœื ื™ืช ืฉืคื•ื’ืขืช ื‘ื™ืœื“ื™ื

ืฆื•ื•ืช ื”ืžื—ืงืจ ืžืงื•ื•ื” ืฉื”ื›ืœื™ื ืฉืคื•ืชื—ื• ื‘ืžื—ืงืจ ื–ื” ื™ืกืœืœื• ืืช ื”ื“ืจืš ืœืคื™ืชื•ื— ื˜ื™ืคื•ืœื™ื ื“ื•ืžื™ื ื‘ืžื—ืœื•ืช ื ื“ื™ืจื•ืช ืื—ืจื•ืช

hayadan.org.il
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RubinsteinLab retweeted
Tel Aviv University
@TelAvivUni15 Jun 2023
TAU's own @BarakBoaz shares insights with #PhD students and #postdocs on effective leadership & career development: "Follow your passions!" network.febs.org/posts/febs-โ€ฆ @of_sagol @FEBSnews

FEBS Excellence Awardee spotlight: Boaz Barak

A quick Q&A with an early-career group leader, including career insights and reflections on effective leadership.

network.febs.org
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ื˜ื™ืคื•ืœ ื’ื ื˜ื™ ื—ื“ืฉื ื™ ืขืฉื•ื™ ืœืกื™ื™ืข ืœืชืกืžื•ื ืช ืืคื™ืœืคืกื™ื” ืฉืคื•ื’ืขืช ื‘ื™ืœื“ื™ื: "ื”ืจืืฉื•ืŸ ืฉื”ื•ื›ื— ื›ื™ืขื™ืœ". ื”ืžื—ืงืจ ื ืขืจืš ื‘ื”ื•ื‘ืœืช ื“"ืจ ืžื•ืจืŸ ืจื•ื‘ื™ื ืฉื˜ื™ื™ืŸ ื•ื”ืกื˜ื•ื“ื ื˜ื™ืช ืกื’'ื ืคื“ื™ืœื” ืžื‘ื™ื”"ืก ืœืจืคื•ืื” ื•ืžื‘ื™ื”"ืก ืกื’ื•ืœ ืœืžื“ืขื™ ื”ืžื•ื— ื‘ืื•ื ' ืช"ื ื•ื“"ืจ ืืจื™ืง ืงืจืžืจ ืžืื•ื ' ืžื•ื ืคืœื™ื™ื” ื‘ืฆืจืคืช. mako.co.il/news-science/2023โ€ฆ @TAUMedFaculty @TelAvivUni
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Do you share a passion of sodium channels and like the WW Nav seminars series? Then mark your calendar for the WW Nav conference Jan31 to Feb2 2024 in Grindelwald, CH.
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RubinsteinLab retweeted
iriareyes@iriareyes17 May 2023
Finally!! ๐Ÿ“ข Our paper is out. Viral vector-mediated expression of NaV1.1, after seizure onset, reduces epilepsy in mice with Dravet syndrome#CAV ๐Ÿฆ  #DravetSyndrome #genetherapy Great collaboration @LabRubinstein @CIMA_unav @IGMM_Montpel @FundacionDravet jci.org/articles/view/159316โ€ฆ
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Hot off the press... see now the manuscript on our new #OpenAccess animal model of #Dravet syndrome developed by our Foundation in a patient-led partnership involving both #industry and #academia. ๐Ÿ‘‰frontiersin.org/articles/10.โ€ฆ
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