@LabRubinstein

We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.

 Israel
moranrub.wixsite.com/rubinsteinlab
Joined October 2018
  • Tweets375
  • Following475
  • Followers388
23Media
📢 A novel gene therapy for #Dravet. jci.org/articles/view/159316…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.
6
9
2
38
5,496
Sleep and thermoregulation are usually coupled. In our new paper, we find that in a #Dravet syndrome 🐭 this coupling collapses, with sleep failing to induce cooling and warmth failing to promote sleep. nature.com/articles/s41467-0… ⸻

Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse model

Nature Communications - In this study, the authors present that sleep onset fails to trigger the normal body-temperature drop, and that warmth does not promote sleep, in a Dravet syndrome mouse...

nature.com
3
1
10
264
This work is dedicated to the memory of Dr. @SajaFadila1, my first student, who led this research 💔
1
6
80
In collaboration with Else Tolner (LUMC) and Eric Kremer (CNRS),  and the amazing teamwork of  Georgii Krivoshein, Hala Majadly, @Anat_Mavashov, Shahak Ranen, Marina Brusel, @iriareyes, and Bernard Boucher 🤩
1
2
62
Congratulation!! 🥳🥳🎈🎈
HaitinLab@HaitinLab30 Nov 2025
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
1
140
RubinsteinLab retweeted
HaitinLab@HaitinLab30 Nov 2025
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
1
2
1
4
347
RubinsteinLab retweeted
HaitinLab@HaitinLab7 Jul 2025
Excited to share our new paper in @FEBSJournal! 🎉 We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation 🔗 doi.org/10.1111/febs.70181 @peterslab1 @TAUMedFaculty
HaitinLab@HaitinLab26 Dec 2024
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
1
4
1
8
710
Congratulations!! 🥳🥳
HaitinLab@HaitinLab2 Jun 2025
How does a cytoplasmic enzyme make a membrane product? 🤔🧬 We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane! MD simulations + fluorescence = mechanistic insight 👇 🔗doi.org/10.1002/pro.70167

Identifying and quantifying membrane interactions of the protein human cis‐prenyltransferase

Prenyl chains come in multiple sizes, fulfilling unique and essential functions across all domains of life. Prenyl chains are synthesized by prenyltransferase proteins. Despite their structural...

onlinelibrary.wiley.com
1
123
RubinsteinLab retweeted
Igor Ulitsky@IgorUlitsky29 May 2025
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/20…
2
31
5
111
14,311
Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 shorturl.at/JL6pyA An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
4
4
1
11
730
An outstanding group of devoted students - Mor Yam, Jolan Nassir, Danielle Galber, Shir Quinn, Roni Gal, Eden Peled, Mor Ovadia, Mor Bordeynik Cohen; Wayne Frankel, Christopher Makinson, Moran Hausman-Kedem, Aviva Fattal-Valevski. @TAUMedFaculty
1
3
164
academic.oup.com/brain/advan…

A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease

Yam et al. characterize a mouse model of GRIN2D-related developmental and epileptic encephalopathy. Grin2d mutant mice exhibit a range of phenotypes that m

academic.oup.com
1
2
95
academic.oup.com/brain/advan…

A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease

Yam et al. characterize a mouse model of GRIN2D-related developmental and epileptic encephalopathy. Grin2d mutant mice exhibit a range of phenotypes that m

academic.oup.com
1
2
85
Excited to share our upgraded #CHD2 mouse model! 🐭🧠 It better mimics the disorder, revealing key symptoms like motor deficits, autistic features & altered brain function⚡️ An amazing collaboration with @IgorUlitsky, supported by @curechd2. 🔗 Read more: biorxiv.org/content/10.1101/…

Alterations in background ECoG activity and behavioral deficits in a mouse model of CHD2-related...

Heterozygous loss of function mutations in the CHD2 gene, encoding for chromodomain helicase DNA-binding protein 2, are associated with severe childhood-onset epilepsy, global developmental delay,...

biorxiv.org
3
7
1
19
1,296
led by the amazing @Anat_Mavashov
2
123
💖Love, Science & the Brain💖 This #ValentinesDay, meet Profs. Moran Rubinstein & Yoni Haitin - a couple bonded by love & a passion for #neuroscience. From BSc to leading labs, their journey is proof that great discoveries are made together. 🔬 Read more: linkedin.com/feed/update/urn…
2
9
351
Congratulations 🎊🎈🎉!
HaitinLab@HaitinLab18 Sep 2024
Amazing!!! 👏🤩 #ProudMentor
1
262
RubinsteinLab retweeted
Alomone labs
@Alomone_Labs26 Mar 2024
The New Dravet syndrome mouse model sheds light on the disease! This research by Prof. Rubinstein & collaborators uses a more accurate mutation to study Dravet & its causes: frontiersin.org/articles/10.… #epilepsyAwarenessDay #DravetSyndrome @FrontiersIn #EpilepsyAwareness

Frontiers | Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense...

Dravet syndrome (Dravet) is a severe congenital developmental genetic epilepsy caused by de novo mutations in the SCN1A gene. Nonsense mutations are found in...

frontiersin.org
1
1
5
1,249
Happy to share our new collaborative paper exploring the molecular basis of DEE-related #SCN8A mutation 🍾 | Work led by @QuinnShir with Yuanyuan Liu, @roybensh, @HaitinLab 🥰, Haim Bassan #epilepsy surl.li/rvzbw
1
5
1
25
2,001
RubinsteinLab retweeted
HaitinLab@HaitinLab7 Mar 2024
Have you ever thought that chloride intracellular channel (CLIC) proteins function as fusogens? 🫧 From 🧪&💎 to 🪱 we're happy to share our recent paper showing just that! nature.com/articles/s41467-0…
7
11
31
2,095
I am sad to report that Bill Catterall has died. He was an enormous presence @UW.
33
19
8
69
41,509
Load more