We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.
Israel
Joined October 2018
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In collaboration with Else Tolner (LUMC) and Eric Kremer (CNRS), and the amazing teamwork of Georgii Krivoshein, Hala Majadly, @Anat_Mavashov, Shahak Ranen, Marina Brusel, @iriareyes, and Bernard Boucher 🤩
This work is dedicated to the memory of Dr. @SajaFadila1, my first student, who led this research 💔
Sleep and thermoregulation are usually coupled. In our new paper, we find that in a #Dravet syndrome 🐭 this coupling collapses, with sleep failing to induce cooling and warmth failing to promote sleep.
nature.com/articles/s41467-0…
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Congratulation!! 🥳🥳🎈🎈
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
RubinsteinLab retweeted
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
RubinsteinLab retweeted
Excited to share our new paper in @FEBSJournal! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs.70181
@peterslab1 @TAUMedFaculty
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
Congratulations!! 🥳🥳
How does a cytoplasmic enzyme make a membrane product? 🤔🧬
We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane!
MD simulations + fluorescence = mechanistic insight 👇
🔗doi.org/10.1002/pro.70167
RubinsteinLab retweeted
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵biorxiv.org/content/early/20…
An outstanding group of devoted students - Mor Yam, Jolan Nassir, Danielle Galber, Shir Quinn, Roni Gal, Eden Peled, Mor Ovadia, Mor Bordeynik Cohen; Wayne Frankel, Christopher Makinson, Moran Hausman-Kedem, Aviva Fattal-Valevski. @TAUMedFaculty
Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 shorturl.at/JL6pyA
An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
