@LabPombo

Genome, genes, regulation @BIMSB_MDC

 Berlin
mdc-berlin.de/pombo
Joined February 2019
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  • Following584
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What are the molecular effects of a single drug exposure 💉 on reward system #dopamine neurons 🧠? We found an unexpected role of 3D genome 🧬 structure in long-term cellular memory of a single #cocaine exposure. @domSzabo @vedranfranke @WarrenWinick @apombo1 @BIMSB_MDC 1/6
bioRxiv@biorxivpreprint13 May 2024
A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons biorxiv.org/cgi/content/shor… #bioRxiv
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This has been a fantastic collaboration involving people across countries 🇩🇪🇬🇧🇩🇰🇮🇹🇨🇦🇪🇸, continents 🌍 🌎 and fields of expertise 🐭💉🧬🔬🖥️. Many thanks to @eleanorjpaul @batxes @samdemharter @lunazere9 @JPLopezAtalaya @MarioNicodemi @AltunaAkalin @khodosevichLab @MarkU65668
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Simona Bianco, Mykahilo Batiuk, Alexander Kukalev, Ulrich Pfisterer, Andrea Chiariello. Thanks to our funders 💰 for supporting the work @BIMSB_MDC @MDC_Berlin @helmholtz_de @4DNucleome @FEBSnews @neurocureberlin @dfg_public @novonordiskfond @LFINetwork @DonnellyCentre
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Extensive folding variability between homologous chromosomes in mammalian cells biorxiv.org/cgi/content/shor… #bioRxiv
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I am very pleased to share that our latest research🧑‍🔬 from @LabPombo, about allele-specific chromatin structure 🧬, now live on bioRxiv. Shout out to @apombo1, Alexander Kukalev, Rieke Kempfer and the rest of the team for this remarkable work of science. ↓ Short thread below ↓
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What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez
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Our paper uncovering the role of SRRM2 splicing factor in stem cell pluripotency is published @BiologyOpen! 🚀 Huge joint effort coming from @LabPombo @BioComicsLab @Silviacamoeira @apombo1 @BIMSB_MDC @UCIBIO_Research @FCTNOVA doi.org/10.1242/bio.060415 ↓ Short thread below ↓

SRRM2 splicing factor modulates cell fate in early development

Summary: This article emphasises the importance of splicing regulators in early mammalian development by uncovering roles of SRRM2 splicing factor dosage in pluripotency, providing novel insights for...

journals.biologists.com
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Splicing alterations precede gene expression events and morphological changes 4/5
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🌱A huge thanks to the @Co_Biologists and to all the reviewers involved on planting our paper as a cherry blossom tree @For_Biologists 🌸 5/5
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Incredibly excited that the DFG is establishing a priority programme in #neuroepigenetics. Initiative lead by Tanja Vogel with support from @BenschZimmer, André Fischer, @apombo1 and myself. Looking forward to great science to emerge from #EPIADAPT! dfg.de/de/service/presse/pre…
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Thanks for the warm welcome these past weeks @QMULepigenetics! What an amazing community to be a part of 🤩🧬👨‍🔬👩‍💻
@qmulepigenetics@QMULepigenetics7 Mar 2024
We are excited to welcome Elena Torlai Triglia @ele_tt qmulepigenetics.com/torlaitr… to @QMULepigenetics. Elena will bring single-cell omics expertise to our Epigenetics Centre, looking forward to all exciting interactions.
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PomboLab retweeted
BarcoLab@BarcoLab7 Mar 2024
We're thrilled to share our latest paper on the role of Kdm1a preserving chromatin compartimentalization and gene silencing! You can check it in the link down below: 👇🏻 nature.com/articles/s41467-0… Don’t miss it! @Beatriz_dBlanco @SergioNi92 #neuroepigenetics #Kdm1a 🧠

Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related...

Nature Communications - Kdm1a is a histone demethylase implicated in intellectual disability. Here, the authors show that removing Kdm1a in neurons of the adult mouse forebrain disrupts silencing...

nature.com
Instituto de Neurociencias UMH-CSIC@NeuroAlc7 Mar 2024
🔥A new study led by @BarcoLab at @NeuroAlc is now published on @NatureComms 🙌 Researchers have determined the role of the Kdm1a protein in maintaining the neuronal identity and relationship with age progression More info 👇 in.umh-csic.es/en/articulos/…
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