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A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!
nature.com/articles/s41586-0…
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez
I was surprised to have learned I received the Emil Bogen Research Prize by reading it in the commencement booklet during the ceremony!
Thank you @UCLA_Pathology for the shout out and @dgsomucla for the recognition.
I am looking forward to starting the next chapter @UCSFPath!
🎓 Congratulations to Dr. Prashant Bhat on graduating from the UCLA DGSOM School of Medicine as part of the UCLA-Caltech Medical Scientist Training Program! This month, Prashant was honored as one of the recipients of the Emil Bogen Research Prize, in recognition of outstanding research achievement.
This July, Dr. Bhat will begin his Pathology Residency in the Physician-Scientist Track at UCSF.
We wish him continued success in this exciting next chapter!
#pathology #Path2Path #PathX #Scientist #MedEd @dgsomucla @uclacaltechmstp
4/2015: First day visiting Caltech
4/2026: Same spot, last day in Pasadena 11 years later!
Kudos to my mom for remembering this picture and wanting to recreate it. Moms know best :)
Also, she wants you to know she didn't age.
@uclacaltechmstp @Caltech @CaltechBBE
ALT Beckman Institute, Caltech, Pasadena, CA
I matched to my #1 program at @UCSFPath in their Clinical Pathology/Physician Scientist Program!
Excited to meet my co-residents & colleagues! Kudos to @uclacaltechmstp, @mitchguttman, Zhen Mei, Dave Dawson and many others at @UCLA_Pathology for their support!
SF, here I come!
Prashant Bhat retweeted
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/ar…
Prashant Bhat retweeted
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s41586-0…
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
Prashant Bhat retweeted
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s41586-0…
Prashant Bhat retweeted
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
nature.com/articles/s41588-0…
Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link:
forms.gle/LopwGCc8RbuCqSu37
Prashant Bhat retweeted
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1).
nature.com/articles/s41580-0…
Delighted to read this article by @TheScientistLLC featuring our work on nuclear speckles! Also features quotes from @mitchguttman and @belmont_andrew.
the-scientist.com/gene-proxi…
Elegant study by @ejkk0 & @daSpliceIsRight identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter + higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!
My PhD work is live on bioRxiv today! :) biorxiv.org/content/10.1101/…
1st yr college (4/2011) Dr. Ambros visited Berkeley. His Cell 1993 paper was the 1st biology paper I ever read. After the talk, I asked for a picture; he looked around him when the organizer clarified,
"Victor, he is asking to take a picture *with* YOU!" 🥲
Congrats, Victor!🧬
ALT UC Berkeley April 7, 2011
Prashant Bhat retweeted
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
Prashant Bhat retweeted
How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our lab & @LafontaineLab + Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.1101/…
Prashant Bhat retweeted
We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA.
biorxiv.org/content/10.1101/…
Prashant Bhat retweeted
Cheer on
@UCSFDeptofEM’s Kishan Patel, MD, as he competes on @CBS #Survivor47 in the Fiji islands! This ER doctor thrives in high-pressure situations. Tune in to see how he outwits and outlasts the competition. #UCSFProud
@UCSFHealth tiny.ucsf.edu/CvJpUD
Prashant Bhat retweeted
Now Online Splicing regulation through biomolecular condensates and membraneless organelles dlvr.it/T7Bmcw
