We use structural and mechanistic biology to study neurotrophic receptors, Rho-effector kinases, and a few other things too @TheCrick. -- run by lab members --
Joined May 2019
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McDonald Lab @ The Crick retweeted
Sandwich student applications are open until 9 October!
We’re looking for motivated undergraduates studying biology, physics, chemistry, engineering, maths or computer science to join a Crick research group or facility for their placement year 🧪📊🔬
crick.ac.uk/careers-study/st…
McDonald Lab @ The Crick retweeted
Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇
crick.ac.uk/careers-study/va…
McDonald Lab @ The Crick retweeted
Hot off the press in @Biochem_Journal where we discuss new insights into aPKC membrane targeting.
These PKCs do not bind DAG to get recruited, instead they fold up their regulatory elements exposing a single membrane binding platform!
read on here👇doi.org/10.1042/BCJ20230390
McDonald Lab @ The Crick retweeted
Fancy doing a PhD with us @TheCrick?
We have a studentship available studying Receptor Tyrosine Kinase function and modulation, to start in Autumn 2023.
#StructuralBiology #CryoEM #MX Application deadline noon (GMT) 10th November.
For details see: crick.ac.uk/careers-study/va…
McDonald Lab @ The Crick retweeted
Structural Biology rant - structures are ‘determined’ not ‘solved’. It is problems e.g. phase or molecular replacement that are solved along the route to determining a structure. There the old man is feeling better now
McDonald Lab @ The Crick retweeted
Interested in how cancers control the immune system? We have a PhD studentship open at the Francis Crick Institute in London to study KRAS oncogene mutant lung cancer and immunotherapy. Apply to join our team by 10 November. #Downwardlab @TheCrick crick.ac.uk/careers-study/va…
McDonald Lab @ The Crick retweeted
Well... It looks like we have our first ever draw in #SynchrotronMugMadness.
Now I have a choice to make. Run the poll again or go for a 3 way final between @desy, @esrfsynchrotron, and @ausynchrotron.
Suggestions welcome.
Stay tuned to find out!
The second semi final match of #SynchrotronMugMadness is now upon us. Today sees Europe facing off against Australasia with @esrfsynchrotron vs @ausynchrotron!
Who will go on to face @desy or the @EuropeanXFEL in the final?
Please vote, like and share your favourites!
50%ESRF
50%Aussie-tron
584 votes • Final results McDonald Lab @ The Crick retweeted
13 years after we determined the structure of 9-1-1 Matt Day, @antonywoliver and me are delighted to offer the structure of human 9-1-1 bound to its RAD17-RFC clamp loader and engaged with a dsDNA-ssDNA junction shrtm.nu/sDCk
McDonald Lab @ The Crick retweeted
Approaching ultimate automation in MX! The last week has been spent commissioning the @EMBLGrenoble CrystalDirect 🤖 @ID30_MASSIF1 We will soon offer fully automatic mounting of crystals from trays for cryo or room temperature experiments 👉 doi.org/doi:10.1021/cg500890…
McDonald Lab @ The Crick retweeted
Courtesy of @pedrobeltrao...
This is chain E of the just-released 7eeb. AlphaFold2 can't possibly have seen it, and a BLAST search of its sequence against the wwPDB comes up empty. Overlaid is the AlphaFold2 prediction, coloured by confidence.
Wha... HOW?
McDonald Lab @ The Crick retweeted
Our #DiamondII upgrade programme will enable the next generation of #SynchrotronScience. Diamond-II will combine a new machine and new beamlines.
To find out about how you can be involved, search our vacancies - vacancies.diamond.ac.uk/home…
McDonald Lab @ The Crick retweeted
Structure and function of retroviral integrase
Maertens, Engelman and Cherepanov explore the structure and function of retroviral integrase and how this knowledge is informing the development of integrase inhibitors for the treatment of HIV infection.
rdcu.be/cn25K
McDonald Lab @ The Crick retweeted
GPs in England ‘failing to recognise thousands of long Covid cases’ theguardian.com/world/2021/j…
McDonald Lab @ The Crick retweeted
Three exciting MX positions @DiamondLightSou. We are searching for a Principal Beamline Scientist for I03 and two PDRAs: 1. serial data analysis with DIALS and 2. electron diffraction at HeXI. See diamond.ac.uk/Careers/Vacanc… for links. @instructhub @ccp4_mx @lightsources @IUCr
McDonald Lab @ The Crick retweeted
Distinct phosphorylation signals drive acceptor versus self-ubiquitination selection by Parkin biorxiv.org/cgi/content/shor… #bioRxiv
McDonald Lab @ The Crick retweeted
The #MarsHelicopter is officially “go” for flight! Can’t wait to watch tomorrow’s historic test. Cameras ready.
#MarsHelicopter, you are cleared for takeoff. Flight commands are being sent.
Watch live on Monday, April 19 at 3:15am PT (6:15am ET/1015 GMT) as the team finds out if they've made history by achieving the first powered flight on another planet. youtu.be/p1KolyCqICI
McDonald Lab @ The Crick retweeted
Exciting opportunity for a chemical biologist to join a multi-disciplinary collaboration between @TheCrick and @GSK to develop reactive fragment screening technology. #ChemBio #chemjobs RT appreciated! jobs.ac.uk/job/CFI652/postdo…
McDonald Lab @ The Crick retweeted
Nanodiscs rule! Lipid environment promotes GPCR–G protein extensive interactions, as shown for neurotensin receptor by the Wagner, Nasr & @alanbrownhms labs @harvardmed.
nature.com/articles/s41594-0…
McDonald Lab @ The Crick retweeted
Cryo-ET highlights: turns out that the ER in the axon is tethered to microtubules along its length. The tethers are clearly visible in tomograms and cluster in patches. biorxiv.org/content/10.1101/…
McDonald Lab @ The Crick retweeted
Interested in kinase networks and pattern formation? We're recruiting! Together with @LabMcDonald, we're looking for an ambitious #interdisciplinary #phdstudent to join our labs @TheCrick to work on multi-scale analysis of #cellpolarity networks. Deadline 23 March!