@Biochem_Journal

Founded in 1906, the Biochemical Journal publishes high-impact research and reviews in 21st century biochemistry, produced by @PPPublishing for the @BiochemSoc.

portlandpress.com/biochemj
Joined January 2021
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Thank you to our community who have engaged with us on this account over the years. We will no longer be posting here, but please do follow us on our main X channels @PPPublishing and @BiochemSoc and follow us on LinkedIn, Bluesky and Instagram for the latest news and research
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In this review article from @MFZlab, the authors explore the role of histone lysine methyltransferases in pancreatic ductal adenocarcinoma development, highlighting potential therapeutic targets. #Cancer #Epigenetics doi.org/10.1042/BCJ20230374
Stepwise enhancer activation mechanism.

ALT Stepwise enhancer activation mechanism.

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Constipation is a forerunner to Parkinson’s disease diagnosis, worsening thereafter. New research from Umamahesan et al examines the relationship of intestinal barrier dysfunction to constipation and whether intestinal fungal load is an aggravating factor. doi.org/10.1042/bcj20240621
View largeDownload slide Hypothesis for aetiopathogenesis of Parkinson’s disease

ALT View largeDownload slide Hypothesis for aetiopathogenesis of Parkinson’s disease

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Explore the latest issue of the Biochemical Journal! Featuring the latest research into the aetiopathogenesis of Parkinson’s disease, tau biology, the CRISPR system, arginine metabolism, heme-regulated inhibitor, and cytochrome P450 4A11. ow.ly/m9ZG50WoUor
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Delve into the mechanisms of mtDNA replication and repair, and well as how this can lead to mtDNA instability and pathological consequences, in this Biochemical Journal review from Nicholls et al.doi.org/10.1042/BCJ20230262
Mechanisms of mtDNA deletion formation.

ALT Mechanisms of mtDNA deletion formation.

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Proteolysis-targeting chimeras (PROTACs) represent a promising modality for probing biological systems and identifying potential therapeutic leads. This review from Osman et al describe the methods used to accelerate PROTAC drug discovery. doi.org/10.1042/bcj20243018
Schematic representation of PROTAC mechanism of action.

ALT Schematic representation of PROTAC mechanism of action.

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Emerging evidence is linking Parkinson’s disease-causing mutations in the LRRK2 gene to dysfunctional axonal transport. This review from Twellsieck et al reviews the role of LRRK2 in axonal transport and Parkinson’s disease.doi.org/10.1042/bcj20253133
LRRK2’s effect on axonal transport.

ALT LRRK2’s effect on axonal transport.

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Arginine is a conditionally essential amino acid, with roles in protein production and intracellular signalling. New research from Hamanaka examined the role and regulation of arginine metabolism in lung fibroblasts activated with TGF-β.doi.org/10.1042/BCJ20253033
TGF-β increases expression of arginine metabolic enzymes and intracellular levels of arginine in human lung fibroblasts (HLFs).

ALT TGF-β increases expression of arginine metabolic enzymes and intracellular levels of arginine in human lung fibroblasts (HLFs).

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Biochemical Journal retweeted
Biochemical Society@BiochemSoc
4 Jul 2025
A massive congratulations to Maxum, Maria Florencia, Eric, Jesús and Nasir, our prize winners from Small G Proteins last week! From oral comms, posters, and audience participation, thank you to @Biochem_Journal, @Cells_MDPI and @FEBS_Letters for sponsoring our #BiochemEvent
Congratulations to our Small G Proteins in Cellular Signalling and Disease 2025 Prize Winners!

ALT Congratulations to our Small G Proteins in Cellular Signalling and Disease 2025 Prize Winners!

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Are you interested in the underlying molecular mechanisms of life? Explore the latest completed issue of the Biochemical Journal which delves into the newest developments in this exciting area! ow.ly/3JiA50Wi4Qc
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In this new #OA Biochemical Journal review, Cantat & Colin discuss using reconstituted actin networks to model actin-related biological processeshttps://portlandpress.com/biochemj/article/482/11/BCJ20253044/236108/Reconstituted-systems-for-studying-the
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Interested in evolutionary biology? This perspective argues that origins of protein kinase A interface with A-Kinase anchoring proteins can be traced to unicellular organisms, which existed long before the emergence of either kinase or anchoring proteins.doi.org/10.1042/bcj20253085
Conservation of the DPY-30 docking and dimerization domain.

ALT Conservation of the DPY-30 docking and dimerization domain.

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New LRRK2 review in the @Biochem_Journal ! Here, @SilasABuck and @LHSanders14 discuss LRRK2’s role in mitochondria and the impact of pathogenic LRRK2 mutations on Parkinson’s diseasehttps://doi.org/10.1042/BCJ20253062
Impact of LRRK2 on mitochondrial dynamics and quality control.

ALT Impact of LRRK2 on mitochondrial dynamics and quality control.

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Working in cancer biology? Then explore our latest #cancerbiology review from Sharma et al which delves into the molecular basis and therapeutic implications of binary YAPOn/YAPOff cancer classeshttps://doi.org/10.1042/BCJ20253077
Mechanisms underlying distinct YAP/TAZ function in YAPon and YAPoff cancers.

ALT Mechanisms underlying distinct YAP/TAZ function in YAPon and YAPoff cancers.

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Biochemical Journal retweeted
Iwasaki_Lab_RIKEN@IwasakiLabRIKEN
17 May 2025
A review regarding the technical advances in ribosome profiling is online! doi.org/10.1042/BST20253061

Advances in ribosome profiling technologies

Ribosome profiling (or Ribo-seq) has emerged as a powerful approach for revealing the regulatory mechanisms of protein synthesis, on the basis of deep sequencing of ribosome footprints. Recent...

portlandpress.com
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Find out about the complex regulation of catalase during the ripening of pepper fruits, including the key role of nitration, in this Biochemical Journal article from Corpas et al. doi.org/10.1042/BCJ20240247
A proposed model summarizes that the activity of the pepper homodimer catalase (Cat) is down-regulated during fruit ripening.

ALT A proposed model summarizes that the activity of the pepper homodimer catalase (Cat) is down-regulated during fruit ripening.

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Are you researching new developments in glycobiology? Submit your work to our new special collection on Glycobiology in the Biochemical Journal guest edited by Natasha Zachara. We welcome original research papers, review articles and opinion pieces ow.ly/jauf50W9ApC
Biochemical Journal Glycobiology Biochemical Journal themed collection- open for research submissions

ALT Biochemical Journal Glycobiology Biochemical Journal themed collection- open for research submissions

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Interested in how plants and plant-soil microbe interactions are adapting to climate change? Look no further than the Biochemical Journal’s themed collection on Plants and climate change: the role of plants in achieving net zero doi.org/10.1042/BCJ20220580
Plant production sustains life on Earth. Most extant life-forms, and humans especially, depend on photosynthetic carbon capture and oxygen production.

ALT Plant production sustains life on Earth. Most extant life-forms, and humans especially, depend on photosynthetic carbon capture and oxygen production.

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Nephrin is a central structural and signaling scaffold in kidney filtration. This review from Williamson et al provides an up-to-date account of nephrin signaling and its specialized effects on the uniquely adaptable podocyte. doi.org/10.1042/BCJ20230234
Mechanisms of nephrin–focal adhesion cross-talk.

ALT Mechanisms of nephrin–focal adhesion cross-talk.

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Inositol plays key roles in many cellular processes, however, the mechanisms maintaining the homeostasis of the inositol remains poorly understood. New research from Su et al explores cellular inositol metabolism through a newly developed LC-MS method.doi.org/10.1042/bcj20253028
Validation of the LC-MS approach for the analysis of inositol.

ALT Validation of the LC-MS approach for the analysis of inositol.

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