McMaster's Centre for Metabolism, Obesity & Diabetes Research translates world leading basic science into clinical practice to improve metabolic disease.
McMaster University, Hamilton, Ontario
Joined January 2019
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New research in @CommsMedicine from @machealthsci & @PHRIresearch investigators shows that hidden abdominal & liver fat may silently harm arteries even in those who look healthy.
healthsci.mcmaster.ca/skinny…
@MacMODR retweeted
MASH: the nexus of metabolism, inflammation and fibrosis
This review by Gregory R. Steinberg @DrGregSteinberg & colleagues @McMasterU is part of JCI’s ongoing series, Evolving Insights into #MASLD and MASH Pathogenesis and Treatment with series editor Scott Friedman: jci.org/articles/view/186420
@MacMODR retweeted
Targeting hepatocyte and tumour lipid metabolism through ACLY inhibition promotes B-cell infiltration/aggregation via CXCL13, resulting in reduced tumour burden in MASH-HCC mouse models nature.com/articles/s41586-0…
“This is one of the first studies to show that targeting metabolism in tumours can enable the immune system to kill liver cancer cells, and opens the door to more effective prevention and treatment strategies for this deadly disease,” @DrGregSteinberg
healthsci.mcmaster.ca/mcmast…
@MacMODR retweeted
New! Online now: Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice dlvr.it/TMB0yf
@MacMODR retweeted
Researchers from across @McMasterU’s Faculty of Health Sciences have secured nearly $19M from @CIHR_IRSC’s Spring 2025 Project Grant Competition.
Explore the full list of newly funded research teams and topics 👇
ow.ly/V8ab50WwI1S
@MacMODR retweeted
Researchers with @MacDeptMed have developed a promising new treatment that helps the immune system attack and kill tumours associated with severe fatty liver disease. @DrGregSteinberg
ow.ly/rjCe50WxwMi
@MacMODR retweeted
ACLY inhibition promotes tumour immunity and suppresses liver cancer nature.com/articles/s41586-0…
Published in @Nature, the findings offer a promising path to better prevention & treatment strategies.
nature.com/articles/s41586-0…
Liver cancer rates are📈in Canada, driven by #fattyliverdisease 🔗to #obesity & #diabetes. Current treatments are limited. Researchers @MacMODR & #EspervitaTherapeutics developed a drug that blocks fat production in tumors, helping #Bcells attack cancer.
ALT Schematic summary illustrating genetic or pharmacologic inhibition of ACLY enhances tumor immunogenicity and resolves MASH-Driven HCC.
Liver cancer rates are📈in Canada, driven by #fattyliverdisease 🔗to #obesity & #diabetes. Current treatments are limited. Researchers @MacMODR & #EspervitaTherapeutics developed a drug that blocks fat production in tumors, helping #Bcells attack cancer.
ALT Schematic summary illustrating genetic or pharmacologic inhibition of ACLY enhances tumor immunogenicity and resolves MASH-Driven HCC.
@MacMODR retweeted
Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice: Cell Metabolism cell.com/cell-metabolism/ful…
@MacMODR retweeted
Here Professor Schertzer and colleagues identify that microbial-derived D-lactate contributes to host glucose and lipid metabolism and can be trapped therapeutically to improve metabolic disease during #obesity cell.com/cell-metabolism/ful…
@MacMODR retweeted
Researchers from @McMasterU @universitelaval @uOttawa have made a discovery that could open the door to new therapies to treat metabolic diseases like type 2 diabetes and fatty liver disease.
Learn more: healthsci.mcmaster.ca/trappi…
@CIHR_IRSC @Farncombe_GI
@MacMODR
‘Trapping’ gut bacteria’s hidden fuel improves blood sugar and liver health, study shows #BrighterWorld #McMaster brighterworld.mcmaster.ca/ar…
New findings from @Schertzerlab out in @cellmetabolism show that trapping microbial D-lactate in the gut ⬇️#bloodglucose, #liverinflammation & #fibrosis in #obese mice. D-lactate⬆️#bloodglucose through a shunt in the #Coricycle, adding to a 100-year-old discovery.
New findings from @Schertzerlab out in @cellmetabolism show that trapping microbial D-lactate in the gut ⬇️#bloodglucose, #liverinflammation & #fibrosis in #obese mice. D-lactate⬆️#bloodglucose through a shunt in the #Coricycle, adding to a 100-year-old discovery.
Another great addition to our March 6 seminar is Maya Bozzo-Rey – MSc (c) in @SergiClotet lab. Her presentation will explore kidney metabolism, epigenetics & sex differences in DKD, with a focus on metabolic responses to high glucose & epigenetic modifications.
Also presenting on March 6 is Meghan Conn – 2nd year MSc (c) in the @SchertzerLab. @MeghanConn01's presentation will describe the metabolic changes that occur during repeated intermittent fasting(IF) & how features of obesity & early T2D affect the metabolic response to IF
Join us on March 6 for the next MODR Seminar, featuring #MODRtrainee Ann Kuganathan - 4th-year PhD(c) in the Krepninsky lab. @annswathyk will share her research on how follistatin improves vascular health & PVAT function in hypertension.
🔗metabolism-research.healthsc…
@MacMODR retweeted
Good luck to all the learners, research staff, as well as family partners and new investigators putting the finishing touches on their #MCHRD2025 abstracts!
Remember to submit your abstracts by this Wed. Feb. 26 at 11:59 PM EST via the MCHRD website ⬇️
pediatrics.healthsci.mcmaste…
