@ImpensLab

We study host-bacteria interactions using Listeria and MS-based Proteomics with a focus on Ubiquitin-like modifications (e.g. ISG15) and MHC complex peptides.

 Ghent, Belgium.
cmb.vib.be/labs/impens-lab/research
Joined October 2021
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  • Following109
  • Followers193
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🚀 Boosting bacterial immunopeptide discovery! Our bioinformatics workflow integrates 4 search engines with follow-up rescoring to enhance ID by 27%, maximizing the discovery of vaccine candidates. Applied to timsTOF/Thermo data🦠💉 @ImpensLab 🔗Read: pubs.acs.org/doi/full/10.102…

Maximizing Immunopeptidomics-Based Bacterial Epitope Discovery by Multiple Search Engines and...

Abstract. Mass spectrometry-based discovery of bacterial immunopeptides presented by infected cells allows untargeted discovery of bacterial antigens that

pubs.acs.org
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Happy to share our immunopeptidomics pipeline using four search engine with follow-up rescoring to boost confident IDs. Also applied to timsTOF SCP data! @ImpensLab @compomics Preprint: biorxiv.org/content/10.1101/…

Maximizing immunopeptidomics-based bacterial epitope discovery by multiple search engines and...

Mass spectrometry-based discovery of bacterial immunopeptides presented by infected cells allows untargeted discovery bacterial antigens that can serve as vaccine candidates. Reliable identification...

biorxiv.org
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Impens Lab retweeted
An Staes@AnStaes26 Apr 2024
Here it is: our paper on the benefit of using in silico predicted libraries in DIA 🎉🎉🎉😎🙏 pubs.acs.org/doi/10.1021/acs… @KrisGevaert_VIB @RalfGabriels @RobbinBouwmees @SaraDuf79861163 @mtpmmaia @VIBProteomxCore @ImpensLab

Benefit of In Silico Predicted Spectral Libraries in Data-Independent Acquisition Data Analysis...

Abstract. Data-independent acquisition (DIA) has become a well-established method for MS-based proteomics. However, the list of options to analyze this typ

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An Staes@AnStaes23 Apr 2024
Proud to have it out there! The setup that boosts our throughput!💪😎 pubs.acs.org/doi/10.1021/acs…

High-Throughput Nanoflow Proteomics Using a Dual-Column Electrospray Source

Abstract. With current trends in proteomics, especially regarding clinical and low input (to single cell) samples, it is increasingly important to both max

pubs.acs.org
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Han Remaut@RemautHan11 Dec 2023
Meet SlyB, a lipoprotein that forms stress-induced #lipidraft in the bacterial outer membrane. Off the hands of the great @ArneJanssens95 and @nguyenson85, in collaboration with @JFClab @ImpensLab and Alex Pak lab. @structbiolbxl @BECM_VIB nature.com/articles/s41586-0…

SlyB encapsulates outer membrane proteins in stress-induced lipid nanodomains

Nature - SlyB, a lipoprotein in the PhoPQ stress regulon in Gram-negative bacteria, forms stable stress-induced complexes with the outer membrane proteome.

nature.com
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VIB@VIBLifeSciences2 Oct 2023
👏Congratulations to @kkariko & @weissmanlab on becoming #NobelPrize laureates. A lifetime achievement celebrating their important research on #mRNA technology in vaccines. 🤔Did you know VIB, together with @VUBrussel, @ugent and participation of several international institutes helped establish the #BAXERNA consortium to further explore the potential of mRNA vaccines?
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Research on #Moyamoya disease @ImpensLab: "Rare diseases result from dysregulated, often yet unknown molecular pathways. Investigating these conditions can lead to groundbreaking fundamental discoveries while opening treatment options for the patients."
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VIB@VIBLifeSciences17 Oct 2022
💉 Francis Impens and team (@ImpensLab @VIB_PRC @VIB_CMB) design an mRNA vaccine against Listeria and open the door for other antibacterial vaccines. bit.ly/3g89LwR
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First day of the 4-day BePA Proteomics Summer School @ VIB starting with interesting talks on Proteomics applications and the DOs and DONTs of sample preparation 👉👉 bit.ly/3CELRCf #proteomics #tech #training #summerschool
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Last chance to register for #NGPAD22! Deadline= 16 May! Join over 200 colleagues 30-31 May #Ghent! 30 excellent academic & industry speakers will discuss their latest findings in the #proteomics field. More info bit.ly/ngpad22 #proteinresearch #Singlecell & much more.
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Here's a first look at the confirmed speakers for #Ubiquitomics2022. Deadline for abstracts and a chance to present your research to the community is July 15th. #ubiquitin #proteomics #massspectrometry
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We are looking for a new colleague! Please spread the word🙂 More info can be found here: jobs.vib.be/j/43810/technolo…
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Save the date for the 4th edition of Next-Generation #ProteinAnalysis and Detection! #NGPAD22 takes place on 30-31 May 2022 in #Ghent. Join these two days filled with #Singlecell, Spatial, Computational, Clinical & Structural #proteomics! More info at: bit.ly/31KB61b
Speaker Line-up for Next-Generation Protein Analysis and Detection (4th edition).

ALT Speaker Line-up for Next-Generation Protein Analysis and Detection (4th edition).

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Mark your agendas and start spreading the news! End of May 2022, VIB's protein analysis and detection conference is coming back to Ghent! vibconferences.be/events/nex…

Next-Generation Protein Analysis and Detection (4th edition)

30-31 May 2022 - Ghent, Belgium A VIB Tools & Technologies conference

vibconferences.be
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DeepLC is out in @naturemethods! Our LC retention time prediction tool for any modification has already shown substantial impact on the analysis of DIA data, proteogenomics, PSM validation, rescoring PSMs... Definitely give it a try for your application! nature.com/articles/s41592-0…
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VIB@VIBLifeSciences18 Oct 2021
🙌 Impressive work by @ImpensLab, @FabienThery1, @svennetti & @lradoshevich26. Their pioneering work on ISG15-mediated defenses vs. bacteria and viruses published in @NatureComms and @NatImmunol today! 👉 bit.ly/3aTWHFj @VIB_CMB @VIBLifeSciences @ugent @VIB_PRC
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