@HC2EM
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Consortium formed by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, & Massachusetts General Hospital. @harvardmed 🟦☁️ @HC2EM
Joined April 2021
- Tweets162
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Harvard Cryo-EM Center for Structural Biology retweeted
Check our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.64898…
Harvard Cryo-EM Center for Structural Biology retweeted
Excited to share our latest work led by our postdoc Dan Zhao! We uncovered how the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase (Pdi1) initiates ERAD. A long-sought ERAD reductase is finally discovered! nature.com/articles/s41594-0…
Huge congratulations!
Harvard Cryo-EM Center for Structural Biology retweeted
Excited about mechanistic biology and processes in the cell's nucleus? Join our lab as a post-doctoral researcher! We have a state-of-the-art cryo-EM facility at HMS, a brand-new lab space, and a vibrant community at HMS! DM/email me or check farnunglab.com
Harvard Cryo-EM Center for Structural Biology retweeted
Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: science.org/doi/10.1126/scie…
Harvard Cryo-EM Center for Structural Biology retweeted
Absolutely thrilled to share paper on Nipah polymerase in close collaboration with Rachel Fearns at Boston University @BU_Tweets. 😃We previously posted on @biorxivpreprint but this is the print form @CellCellPress. 🦇 @HarvardMicro @gatesfoundation
cell.com/cell/fulltext/S0092…
Harvard Cryo-EM Center for Structural Biology retweeted
Excited to share our @biorxivpreprint led by @xiaoyi_fann and @wanyuviridae exploring how binding of western equine encephalitis virus (WEEV) to its cellular receptors evolved over the past century 🤩 biorxiv.org/content/10.1101/… @HarvardMicro
Harvard Cryo-EM Center for Structural Biology retweeted
1/n) Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with
@TzviyaZBM and @alanbrownhms
nature.com/articles/s41586-0…
Harvard Cryo-EM Center for Structural Biology retweeted
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @MarkertJon tinyurl.com/setd2
Harvard Cryo-EM Center for Structural Biology retweeted
A nice piece on one our @CellCellPress papers published earlier this year about mechanisms of herpes simplex virus polymerase drug resistance related to conformational dynamics. 🕺
drugdiscoverynews.com/protei…
Harvard Cryo-EM Center for Structural Biology retweeted
Excited to share our most recent paper at @CellCellPress in which we used #CryoEM to study conformational dynamics as a determinant of drug selectivity and resistance for the herpes simplex virus DNA polymerase. cell.com/cell/fulltext/S0092…
Harvard Cryo-EM Center for Structural Biology retweeted
We are excited to share our @NatureComms paper by postdoc Pan @an32169364 and @VirologyHarvard grad student Wanyu @wanyuviridae on the structural binding mode of eastern equine encephalitis virus (EEEV) and Semliki forest virus (SFV) with receptor VLDLR
rb.gy/2ryjcu
Harvard Cryo-EM Center for Structural Biology retweeted
Congrats everybody, that took a while from the preprint 😅💪 nature.com/articles/s41589-0…
Harvard Cryo-EM Center for Structural Biology retweeted
A new paper from Benjamin Ebert, Nathanael Gray, @eric_fischer, @fischerlab1, @LiYender, Michelle Ma, and @M_MurtazaHassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW
Harvard Cryo-EM Center for Structural Biology retweeted
STK19 is a bona fide transcription-coupled repair factor. Check out the preprint with @FrogWalterLab ➡️bit.ly/4fgl2Fq
We achieved a major technical milestone: 1.9 Å resolution structure of an RNA polymerase II transcription complex. Txn goes sub-2 Å!
Harvard Cryo-EM Center for Structural Biology retweeted
Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of @MolecularCell! cell.com/molecular-cell/full… 1/n
Harvard Cryo-EM Center for Structural Biology retweeted
Excited to share @biorxivpreprint in collaboration with Rachel Fearns at BU in which we determined the cryo-EM structure of the Nipah virus polymerase complex! The complex assembles with a tobacco pipe-like shape with a flexible stem (do you see it?)😃😅biorxiv.org/content/10.1101/…
Harvard Cryo-EM Center for Structural Biology retweeted
Antibodies expand the scope of angiotensin receptor pharmacology | Nat Chem Biol
doi.org/10.1038/s41589-024-0…
Harvard Cryo-EM Center for Structural Biology retweeted
The 20S proteasome plays a key protease role in many regulatory processes. Yet, how its ordered biogenesis and temporally timed catalytic site activation works has remained elusive. In our latest work, we provide evidence for how that occurs! @NatureSMB rdcu.be/dElr4
Harvard Cryo-EM Center for Structural Biology retweeted
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2 dlvr.it/T54tGQ
Harvard Cryo-EM Center for Structural Biology retweeted
Scientists uncover potential path to treating deadly childhood tumor statnews.com/2024/04/01/chil…
