FrattaLab retweeted
#RepeatExpansionDisorders are up to three times more common than current estimates. Underdiagnosis or reduced penetrance?
by our wonderful dream team @kriski_ibanez @mattzano @chrsclrksn + Bharati Jadhav & Andy Sharp
nature.com/articles/s41591-0…
FrattaLab retweeted
We're looking for someone with a creative mindset and excellent modern molecular biology skills (DNA manipulation, Illumina, Nanopore etc) to join our team at @ucl and @TheCrick in the @FrattaLab developing candidate gene therapies for ALS. Apply here: jobs.ac.uk/job/DGJ551/resear…
FrattaLab retweeted
Why small mindedness is having big consequences @Brain1878
I live under its shadow. I suspect most of you do too. It is the great mountain of small things. The higher it gets, the bigger the shadow it casts: a malignant darkness that pervades our lives.
academic.oup.com/brain/artic…
FrattaLab retweeted
Do you love #RNA and #neuroscience? Are you looking for a #postdocposition on #ALS and gene therapy? Join @RueppLab @UKDRI @KingsIoPPN and @FrattaLab @UCLIoN for a collaborative pre-clinical project on a novel gene therapy approach for ALS. More info here: tinyurl.com/2cpcbsp3
FrattaLab retweeted
Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/shor… 1/9
FrattaLab retweeted
Our latest @NeuroCellPress reveals widespread mislocalisation of proteins & mRNAs in ALS. This is partly reversed by VCP ATPase inhibition: cell.com/neuron/pdfExtended/… @UCLIoN @mndassoc @The_MRC @ListerInstitute @ojziff @harleyinthehood @erist_yiran @JacobNeeves @PataniLab @TheCrick
FrattaLab retweeted
Check out our new preprint on generation and characterisation of C9orf72 polyGR and polyPR knock-in mice. A huge effort over many years by @milioto_carmelo and many collaborators incl. @marcaurelbusche @soyonhonglab
biorxiv.org/cgi/content/shor… 1/5
FrattaLab retweeted
I'll be speaking about my research on TDP-43 cryptic exons in ALS/FTD at an online ECR event at the end of this month. Come watch! (registration is free 😁 )
Registration link here: bit.ly/3h38Gqz
FrattaLab retweeted
Great opportunity to join our team (@FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link: tinyurl.com/bddjtjvc
FrattaLab retweeted
Now published! Congratulations @ricardovialle! Our efforts in identification of structural variants (#SVs) in 1,760 whole genomes,& quantification of effects of cis-SVs on brain gene expression, histone mods, splicing, and protein levels (SV-xQTLs)! @NatureNeuro
@IcahnMountSinai
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FrattaLab retweeted
New opportunity for a Bioinformatics Research Fellow to join @adrianisaacslab @FrattaLab 👩🔬🧑🔬
Interesting role working at the interface between computational and wet labs, investigating the underlying mechanisms of ALS 🧠
🗓️ 13 March 👉 bit.ly/3vWZ7Pz
FrattaLab retweeted
Exciting bioinformatics position to work between me and @FrattaLab closes March 13th! jobs.ac.uk/job/CMN922/resear…
FrattaLab retweeted
Diagnostics of repeat expansions has relied on targeted PCR tests. We now show that #WGS can detect pathogenic expansions at a clinical diagnostic standard.
Out now @TheLancetNeuro!
@GenomicsEngland @UCLIoN @NHSgms @illumina @QMUL
thelancet.com/journals/laneu…
FrattaLab retweeted
We’re hiring! The Raj Lab is looking for postdoctoral fellows to work on projects using computational approaches to identify drivers of neurodegenerative diseases. DM for more info! Pls RT.
#ScienceJobs #AcademicTwitter
#Genomics
FrattaLab retweeted
Our latest work on rare dementia #FTLD/#FTD with TDP-43 pathology.
link.springer.com/article/10…
Congratulations to a very talented Master’s student Rahat Hasan & @JackHumphrey_ for co-mentoring! See 👇🏼 for more:
Our new preprint on rare dementia #FTLD/#FTD finds widespread cellular composition changes in both cortex and cerebellum, with neuronal loss, glial activation and vascular changes. @SinaiBrain @SinaiGenetics
FrattaLab retweeted
Delighted to share our recent preprint focusing on the regulation of #axonaltransport by #BDNF in #ALS/#MND. Huge thanks to the collaborative partners @J_N_Slayer
@sunaina_surana
@ellierhymes
@Stephen_Cahalan
& all members of @SchiavoMNPlab @FrattaLab
biorxiv.org/content/10.1101/…
FrattaLab retweeted
New preprint @medrxiv on my work in #genomics of #ALS/#MND - Integrative genetic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes medrxiv.org/content/10.1101/… 🧵 below: (1/9)
FrattaLab retweeted
Yet more excellent post-doc positions. Here's one of several in Fratta lab to study ALS: atsv7.wcn.co.uk/search_engin…
FrattaLab retweeted
Job Vacancy: great opportunity to join @FrattaLab to investigate the role of UNC13A reduction in ALS pathogenesis with @FrattaPietro @UCLIoN @UCLBrainScience atsv7.wcn.co.uk/search_engin…